Measurement of mitochondrial Ca2+ transport mediated by three transport proteins: VDAC1, the NA+/CA2+ exchanger, and the CA2+ uniporter

Cold Spring Harbor Protocols

Volumn 2014, Issue 2, 2014, Pages 161-166

  Ben Hail, Danya ^a   Palty, Raz ^b   Shoshan Barmatz, Varda ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM CHANNEL; MITOCHONDRIAL CALCIUM UNIPORTER; SODIUM CALCIUM EXCHANGE PROTEIN; VOLTAGE DEPENDENT ANION CHANNEL 1;

ANIMAL; HUMAN; METABOLISM; MITOCHONDRION; REVIEW; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CALCIUM CHANNELS; HUMANS; MITOCHONDRIA; SODIUM-CALCIUM EXCHANGER; VOLTAGE-DEPENDENT ANION CHANNEL 1;

EID: 84893247772     PISSN: 19403402     EISSN: 15596095     Source Type: Journal    
DOI: 10.1101/pdb.top066241     Document Type: Article

References (52)

1. 2+ dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC). J Biol Chem 281: 17347-17358.
2. Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, et al. 2011. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 476: 341-345.
3. Ben-Hail D, Shoshan-Barmatz V. 2014a. Purification of VDAC1 from rat liver mitochondria. Cold Spring Harbor Protoc doi: 10.1101/pdb.prot073130.
4. Ben-Hail D, Shoshan-Barmatz V. 2014b. Reconstitution of purified VDAC1 into a lipid bilayer and recording of channel conductance. Cold Spring Harbor Protoc doi: 10.1101/pdb.prot073148.
5. 2+ transport by VDAC1 reconstituted into liposomes. Cold Spring Harbor Protoc doi: 10.1101/pdb.prot073155.
6. 2+ efflux via the MPTP. Cold Spring Harbor Protoc doi: 10.1101/pdb.prot073163.
7. Benz R. 1994. Permeation of hydrophilic solutes through mitochondrial outer membranes: Review on mitochondrial porins. Biochim Biophys Acta 1197: 167-196.
8. Benz R, Kottke M, Brdiczka D. 1990. The cationically selective state of the mitochondrial outer membrane pore: A study with intact mitochondria and reconstituted mitochondrial porin. Biochim Biophys Acta 1022: 311-318.
9. Berridge MJ, Bootman MD, Roderick HL. 2003. Calcium signalling: Dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4: 517-529.
10. Colombini M. 1994. Anion channel in the mitochondrial outer membrane. Curr Topics Membrane 42: 73-101.
11. 2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria. J Biol Chem 268: 938-947.
12. Crompton M, Capano M, Carafoli E. 1976. The sodium induced efflux of calcium from heart mitochondria. A possible mechanism for the regulation of mitochondrial calcium. Eur J Biochem 69: 453-462
13. De Pinto V, Guarino F, Guarnera A, Messina A, Reina S, Tomasello FM, Palermo V, Mazzoni C. 2010. Characterization of human VDAC isoforms: A peculiar function for VDAC3? Biochim Biophys Acta 1797: 1268-1275.
14. De Stefani D, Raffaello A, Teardo E, Szabo I, Rizzuto R. 2011. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 476: 336-340.
15. Denton RM. 2009. Regulation of mitochondrial dehydrogenases by calcium ions. Biochim Biophys Acta 1787: 1309-1316.
16. 2+ as a key regulator of cell life and death. Cell Death Differ 14: 1267-1274.
17. Gincel D, Silberberg SD, Shoshan-Barmatz V. 2000. Modulation of the voltage-dependent anion channel (VDAC) by glutamate. J Bioenerg Biomembr 32: 571-583.
18. Gincel D, Vardi N, Shoshan-Barmatz V. 2002. Retinal voltage-dependent anion channel: Characterization and cellular localization. Invest Ophthalmol Vis Sci 43: 2097-2104.
19. Gincel D, Zaid H, Shoshan-Barmatz V. 2001. Calcium binding and translocation by the voltage-dependent anion channel: A possible regulatory mechanism in mitochondrial function. Biochem J 358: 147-155
20. 2+ transport mechanisms. Biochim Biophys Acta 1787: 1291-1308.
21. Gunter TE, Buntinas L, Sparagna G, Eliseev R, Gunter K. 2000. Mitochondrial calcium transport: Mechanisms and functions. Cell Calcium 28: 285-296.
22. Gunter TE, Yule DI, Gunter KK, Eliseev RA, Salter JD. 2004. Calcium and mitochondria. FEBS Lett 567: 96-102.
23. Hodge T, Colombini M. 1997. Regulation of metabolite flux through voltage-gating of VDAC channels. J Membr Biol 157: 271-279.
24. 2+ uptake-A revisit. Mol Cell Endocrinol 353: 114-127.
25. + antiporter. Science 326: 144-147
26. 2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets. Diabetes 52: 965-973.
27. 2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes. Circ Res 99: 172-182.
28. Maechler P, Kennedy ED, Pozzan T, Wollheim CB. 1997. Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells. EMBO J 16: 3833-3841.
29. Nichols BJ, Denton RM. 1995. Towards the molecular basis for the regulation of mitochondrial dehydrogenases by calcium ions. Mol Cell Biochem 149-150: 203-212.
30. Nowikovsky K, Pozzan T, Rizzuto R, Scorrano L, Bernardi P. 2012. Perspectives on: SGP symposium on mitochondrial physiology and medicine: The pathophysiology of LETM1. J Gen Physiol 139: 445-454
31. 2+ exchange. Proc Natl Acad Sci 107: 436-441.
32. 2+ exchanger. Cell Calcium 52: 9-15.
33. 2+ exchange assays. Cold Spring Harbor Protoc doi: 10.1101/pdb.prot073171.
34. 2+ influx mechanisms. Sci China Life Sci 54: 763-769.
35. 2+ uptake. Nature 467: 291-296.
36. 2+ homeostasis: Mechanism, role, and tissue specificities. Pflugers Arch 464: 3-17.
37. 2+ microdomains to mitochondria. J Cell Biol 159: 613-624.
38. 2+-dependent apoptosis and necrosis. Cell Calcium 50: 222-233.
39. Rostovtseva T, Colombini M. 1997. VDAC channels mediate and gate the flow of ATP: Implications for the regulation of mitochondrial function. Biophys J 72: 1954-1962.
40. 2+ permeable channels. FEBS Lett 584: 1948-1955.
41. Santo-Domingo J, Demaurex N. 2010. Calcium uptake mechanisms of mitochondria. Biochim Biophys Acta 1797: 907-912.
42. Schein SJ, Colombini M, Finkelstein A. 1976. Reconstitution in planar lipid bilayers of a voltage-dependent anion-selective channel obtained from paramecium mitochondria. J Membr Biol 30: 99-120.
43. Shafir I, Feng W, Shoshan-Barmataz V. 1998. Voltage-dependent anion channel proteins in synaptosomes of the torpedo electric organ: Immunolocalization, purification, and characterization. J Bioenerg Biomembr 30: 499-510.
44. Shoshan-Barmatz V, Gincel D. 2003. The voltage-dependent anion channel: Characterization, modulation, and role in mitochondrial function in cell life and death. Cell Biochem Biophys 39: 279-292.
45. Shoshan-Barmatz V, Hadad N, Feng W, Shafir I, Orr I, Varsanyi M, Heilmeyer LM. 1996. VDAC/porin is present in sarcoplasmic reticulum from skeletal muscle. FEBS Lett 386: 205-210.
46. Shoshan-Barmatz V, Israelson A, Brdiczka D, Sheu SS. 2006. The voltage-dependent anion channel (VDAC): Function in intracellular signalling, cell life and cell death. Curr Pharm Des 12: 2249-2270.
47. Shoshan-Barmatz V, De Pinto V, Zweckstetter M, Raviv Z, Keinan N, Arbel N. 2010. VDAC, a multi-functional mitochondrial protein regulating cell life and death. Mol Aspects Med 31: 227-285.
48. Tan W, Colombini M. 2007. VDAC closure increases calcium ion flux. Biochim Biophys Acta 1768: 2510-2515.
49. Tsujimoto Y, Shimizu S. 2007. Role of the mitochondrial membrane permeability transition in cell death. Apoptosis 12: 835-840.
50. 2+ transport and respiration in rat liver mitochondria. Biochim Biophys Acta 256: 43-54.
51. Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, Paulson HL, Yang L, Kotin RM, Davidson BL. 2004. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat Med 10: 816-820.
52. + exchange. J Biol Chem 285, 14399-14414.