Hydrogen peroxide content and pH of expired breath condensate from patients with asthma and COPD

COPD: Journal of Chronic Obstructive Pulmonary Disease

Volumn 11, Issue 1, 2014, Pages 81-87

  Murata, Kazuya ^a   Fujimoto, Keisaku ^b   Kitaguchi, Yoshiaki ^a   Horiuchi, Toshimichi ^a   Kubo, Keishi ^a   Honda, Takayuki ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY   (Japan)

Author keywords

Asthma; Biomarkers; Clinical respiratory medicine; COPD; Inflammation

Indexed keywords

HYDROGEN PEROXIDE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

ADULT; AGED; ARTICLE; ASTHMA; ASTHMA CONTROL TEST; CHRONIC OBSTRUCTIVE LUNG DISEASE; CHRONIC OBSTRUCTIVE PULMONARY DISEASE ASSESSMENT TEST; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE MARKER; DISEASE SEVERITY; EXPIRED AIR; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OXIDATIVE STRESS; PH; PRIORITY JOURNAL; REACTIVE OXYGEN METABOLITES EXHALATION TEST KIT; RESPIRATORY EQUIPMENT; RESPIRATORY TRACT EXAMINATION;

ADULT; AGED; ASTHMA; BIOLOGICAL MARKERS; BREATH TESTS; CASE-CONTROL STUDIES; FEMALE; HUMANS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; LUNG; MALE; MIDDLE AGED; NITRIC OXIDE; OXIDATIVE STRESS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84893215805     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.3109/15412555.2013.830094     Document Type: Article

References (33)

1. Lin JL, Th omas PS. Current perspectives of oxidative stress and its measurement in chronic obstructive pulmonary disease. COPD 2010; 7:291-306.
2. Teng Y, Sun P, Zhang J, et al. Hydrogen peroxide in exhaled breath condensate in patients with asthma: a promising biomarker? Chest 2011; 140:108-116.
3. Guatura SB, Martinez JA, Santos Bueno PC, et al. Increased exhalation of hydrogen peroxide in healthy subjects following cigarette consumption. Sao Paulo Med J 2000; 118:93-98.
4. Dekhujzen PN, Aben KK, Dekker I, et al. Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996; 154:813-816.
5. Kostikas K, Papatheodorou G, Ganas K, et al. pH in expired breath condensate of patients with infl ammatory airway diseases. Am J Respir Crit Care Med 2002; 165:1364-1370.
6. Lin J-L, Bonnichsen MH, Th omas PS. Standardization of exhaled breath condensate: eff ects of diff erent de-aeration protocols on pH and H2O2 concentrations. J Breath Res 2011 Mar; 5(1): 011001. doi: 10.1088/1752-7155/5/1/ 011001. Epub 2011 Jan 11.
7. Papaioannou AI, Loukides S, Minas M, et al. Exhaled breath condensate pH as a biomarker of COPD severity in ex-smokers. Respir Res 2011; 22:12-67.
8. National Institute of Health, National Heart, Lung and Blood Institute. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management an Prevention of Chronic Obstructive Pulmonary Disease. 2011; Available at www.goldcopd.com.
9. Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. Workshop Report. Update 2006. http://www.ginasthma. com.
10. Nishida O, Kambe M, Sewake N, et al. Pulmonary function in healthy subjects and its prediction: 5. Pulmonary diff using capacity in adults. Jpn J Clin Pathol 1976; 24:941-947.
11. Boren HG, Kory RC, Syner LC, et al. Th e veterans administration-army cooperative study of pulmonary function. The lung volume and its subdivisions in normal men. Am J Med 1966; 41:96-101.
12. Bodini A, Peroni D, Loiacono A, et al. Exhaled nitric oxide daily evaluation is eff ective in monitoring exposure to relevant allergens in asthmatic children. Chest 2007; 132:1520-1525.
13. Alberti A, Bolognini L, Macciantelli D, et al. Th e radical cation of N,N-diethyl-para-phenylendiamine: a possible indicator of oxidative stress in biological samples. Res Chem Intermed 2000; 26:253-267.
14. Melillo G, Iorio EL, Giuliano F, et al. Oxidative stress in patients with chronic obstructive pulmonary disease: validation of a new photometric test (exhalation test) for the measurement of hydrogen peroxide in exhaled breath condensate. Rass Patol App Resp 2007; 22:98-104.
15. Goddard PR, Nicholson EM, Laszlo G, et al. Computed tomography in pulmonary emphysema. Clin Radiol 1982; 33:379-387.
16. Loukides S, Bouros D, Papatheodorou G, et al. Th e relationship among hydrogen peroxide in expired breath condensate, airway infl ammation, and asthma severity. Chest 2002; 121:338-346.
17. Ganas K, Loukides S, Papatheodorou G, et al. Total nitrite/ nitrate in expired breath condensate of patients with asthma. Respir Med 2001; 95:649-654.
18. Horvath I, Donnelly LE, Kiss A, et al. Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am J Respir Crit Care Med 1998; 158:1042- 1046.
19. Nathan RA, Sorkness CA, Kosinski M, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 2004; 113: 59-65.
20. Kharitonov S, Alving K, Barnes PJ: Exhaled and nasal nitric oxide measurements: recommendations. Th e European Respiratory Society Task Force. Eur Respir J 1997; 10:1683-1693.
21. Montuschi P, Mondino C, Koch P, et al. Eff ects of Montelukast treatment and withdrawal on fractional exhaled nitric oxide and lung function in children with asthma. Chest 2007; 132:1876-1881.
22. Petsky HL, Cates CJ, Li A, et al. Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults. Cochrane Database Syst Rev 2009; 4:CD006340: doi: 10.1002/14651858.
23. Montuschi P, Barnes PJ. New perspectives in pharmacological treatment of mild persistent asthma. Drug Discov Today 2011; 16:1084-1091.
24. Jones PW, Harding G, Berry P, et al. Development and fi rst validation of the COPD assessment test. Eur Respir J 2009; 34:648-654.
25. Mackay AJ, Donaldson GC, Patel AR, et al. Utility of the COPD assessment test (CAT) to evaluate severity of COPD exacerbations. Am J Respir Crit Care Med 2012; 185:1218-24.
26. Kostikas K, Papatheodorou G, Psathakis K, et al. Oxidative stress in expired breath condensate of patients with COPD. Chest 2003; 124:1373-1380.
27. Singh D, Edwards L, Tal-Singer R, Rennard S. Sputum neutrophils as a biomarker in COPD: fi ndings from the ECLIPSE study. Respir Res 2010; 11:77.
28. Ojoo JC, Mulrennan SA, Kastelik JA, et al. Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fi brosis. Thorax 2005; 60:22-26.
29. Carraro S, Folesani G, Corradi M, et al. Acid-base equilibrium in exhaled breath condensate of allergic asthmatic children. Allergy 2005; 60:476-481.
30. Antus B, Barta I, Kullmann T, et al. Assessment of exhaled breath condensate pH in exacerbations of asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010; 182:1492-1497.
31. Van Beurden WJ, Dekhuijzen PN, Harf GA, et al. Variability of exhaled hydrogen peroxide in stable COPD patients and matched healthy controls. Respiration 2002; 69:211-216.
32. Nowak D, Kasielski M, Pietras T, et al. Cigarette smoking does not increase hydrogen peroxide levels in expired breath condensate of patients with stable COPD. Monaldi Arch Chest Dis 1998; 53:268-273.
33. Nowak D, Kalucka S, Bialasiewicz P, et al. Exhalation of H2O2 and thiobarbituric acid reactive substances (TBARS) by healthy subjects. Free Radic Biol Med 2001; 30:178- 186.