Sputum neutrophils as a biomarker in COPD: Findings from the ECLIPSE study

Respiratory Research

Volumn 11, Issue , 2010, Pages

  Singh, Dave ^a   Edwards, Lisa ^b   Tal Singer, Ruth ^b   Rennard, Stephen ^c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BIOLOGICAL MARKER; BRONCHODILATING AGENT; C REACTIVE PROTEIN; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; INTERLEUKIN 6; INTERLEUKIN 8; SURFACTANT PROTEIN C; SURFACTANT PROTEIN D; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN;

ADULT; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE EXACERBATION; EMPHYSEMA; FEMALE; FORCED EXPIRATORY VOLUME; HEALTH STATUS; HUMAN; HUMAN CELL; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL COUNT; PROTEIN BLOOD LEVEL; QUESTIONNAIRE; SPUTUM; ST GEORGES RESPIRATORY QUESTIONAIRRE; AGED; BLOOD; CANADA; CLINICAL TRIAL; CYTOLOGY; EUROPE; HOSPITALIZATION; IMMUNOLOGY; LONGITUDINAL STUDY; LUNG EMPHYSEMA; LYMPHOCYTE COUNT; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; NEUTROPHIL; NEW ZEALAND; PATHOPHYSIOLOGY; PROGNOSIS; PROSPECTIVE STUDY; RADIOGRAPHY; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL; TIME; UNITED STATES;

AGED; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CANADA; EUROPE; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; IMMUNOASSAY; INTERLEUKIN-6; INTERLEUKIN-8; LINEAR MODELS; LONGITUDINAL STUDIES; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEUTROPHILS; NEW ZEALAND; PROGNOSIS; PROSPECTIVE STUDIES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY EMPHYSEMA; PULMONARY SURFACTANT-ASSOCIATED PROTEIN D; QUESTIONNAIRES; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SPUTUM; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; UNITED STATES;

EID: 77956686967     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-11-77     Document Type: Article

References (27)

1. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Paré PD. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Eng J Med 2004, 350:2645-2652.
2. The Global Initiative for Chronic Obstructive Lung Disease (GOLD). , http://www.goldcopd.com
3. Barnes PJ, Chowdhury B, Kharitonov SA, Magnussen H, Page CP, Postma D, Saetta M. Pulmonary biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006, 174:6-14. 10.1164/rccm.200510-1659PP, 16556692.
4. O'Donnell RA, Peebles C, Ward JA, Daraker A, Angco G, Broberg P, Pierrou S, Lund J, Holgate ST, Davies DE, Delany DJ, Wilson SJ, Djukanovic R. Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD. Thorax 2004, 59:837-42. 10.1136/thx.2003.019349, 1746844, 15454648.
5. Keatings VM, Collins PD, Scott DM, Barnes PJ. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 1996, 153:530-4.
6. Rutgers SR, Timens W, Kaufmann HF, van der Mark TW, Koëter GH, Postma DS. Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD. Eur Respir J 2000, 15:109-15. 10.1183/09031936.00.15110900, 10678630.
7. Cowburn AS, Condliffe AM, Farahi N, Summers C, Chilvers ER. Advances in neutrophil biology: clinical implications. Chest 2008, 134:606-12. 10.1378/chest.08-0422, 2827863, 18779195.
8. Yanbaeva DG, Dentener MA, Spruit MA, Houwing-Duistermaat JJ, Kotz D, Passos VL, Wouters EF. IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study. BMC Med Genet 2009, 10:23. 10.1186/1471-2350-10-23, 2660301, 19272152.
9. Chung KF, Adcock IM. Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction. Eur Respir J 2008, 31:1334-56. 10.1183/09031936.00018908, 18515558.
10. Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 2004, 59:574-80. 10.1136/thx.2003.019588, 1747070, 15223864.
11. Vestbo J, Anderson W, Coxson HO, Crim C, Dawber F, Edwards L, Hagan G, Knobil K, Lomas DA, MacNee W, Silverman EK, Tal-Singer R. ECLIPSE investigators. Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE). Eur Respir J 2008, 31:869-73. 10.1183/09031936.00111707, 18216052.
12. Pizzichini E, Pizzichini MM, Efthimiadis A, Evans S, Morris MM, Squillace D, Gleich GJ, Dolovich J, Hargreave FE. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med 1996, 154:308-17.
13. Coxson HO, Rogers RM, Whittall KP, D'yachkova Y, Paré PD, Sciurba FC, Hogg JC. A quantification of the lung surface area in emphysema using computed tomography. Am J Respir Crit Care Med 1999, 159:851-856.
14. O'Donnell RA, Peebles C, Ward JA, Daraker A, Angco G, Broberg P, Pierrou S, Lund J, Holgate ST, Davies DE, Delany DJ, Wilson SJ, Djukanovic R. Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD. Thorax 2004, 59:837-42. 10.1136/thx.2003.019349, 1746844, 15454648.
15. Roy K, Smith J, Kolsum U, Borrill Z, Vestbo J, Singh D. COPD phenotype description using principal components analysis. Respir Res 2009, 10:41. 10.1186/1465-9921-10-41, 2698901, 19480658.
16. Lapperre TS, Snoeck-Stroband JB, Gosman MM, Stolk J, Sont JK, Jansen DF, Kerstjens HA, Postma DS, Sterk PJ. Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004, 170:499-504. 10.1164/rccm.200401-112OC, 15172889.
17. Donaldson GC, Seemungal TA, Patel IS, Bhowmik A, Wilkinson TM, Hurst JR, Maccallum PK, Wedzicha JA. Airway and systemic inflammation and decline in lung function in patients with COPD. Chest 2005, 128:1995-2004. 10.1378/chest.128.4.1995, 16236847.
18. Stanescu D, Sanna A, Veriter C, Kostianev S, Calcagni PG, Fabbri LM, Maestrelli P. Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils. Thorax 1996, 51:267-71. 10.1136/thx.51.3.267, 1090637, 8779129.
19. Sharafkhaneh A, Hanania NA, Kim V. Pathogenesis of emphysema: from the bench to the bedside. Proc Am Thorac Soc 2008, 5:475-7. 10.1513/pats.200708-126ET, 2645322, 18453358.
20. Boschetto P, Quintavalle S, Zeni E, Leprotti S, Potena A, Ballerin L, Papi A, Palladini G, Luisetti M, Annovazzi L, Iadarola P, De Rosa E, Fabbri LM, Mapp CE. Association between markers of emphysema and more severe chronic obstructive pulmonary disease. Thorax 2006, 61:1037-42. 10.1136/thx.2006.058321, 2117071, 16769715.
21. Caramori G, Romagnoli M, Casolari P, Bellettato C, Casoni G, Boschetto P, Chung KF, Barnes PJ, Adcock IM, Ciaccia A, Fabbri LM, Papi A. Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. Thorax 2003, 58:348-51. 10.1136/thorax.58.4.348, 1746629, 12668802.
22. Papi A, Bellettato CM, Braccioni F, Romagnoli M, Casolari P, Caramori G, Fabbri LM, Johnston SL. Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med 2006, 173:1114-21. 10.1164/rccm.200506-859OC, 16484677.
23. Soler-Cataluña JJ, Martínez-García MA, Román Sánchez P, Salcedo E, Navarro M, Ochando R. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax 2005, 60:925-31. 10.1136/thx.2005.040527, 1747235, 16055622.
24. Snoeck-Stroband JB, Postma DS, Lapperre TS, Gosman MM, Thiadens HA, Kauffman HF, Sont JK, Jansen DF, Sterk PJ. Airway inflammation contributes to health status in COPD: a cross-sectional study. Respir Res 2006, 7:140. 10.1186/1465-9921-7-140, 1697818, 17137518.
25. Beeh K, Beier J, Kornmann O, Mander A, Buhl R. Long-term Repeatability of Induced Sputum Cells and Inflammatory Markers in Stable, Moderately Severe COPD. Chest 2003, 123:778-83. 10.1378/chest.123.3.778, 12628878.
26. Brightling C, Monteiro W, Green R, Parker D, Morgan MD, Wardlaw AJ, Pavord D. Induced sputum and other outcome measures in chronic obstructive pulmonary disease: safety and repeatability. Respiratory Medicine 2001, 95:999-1002. 10.1053/rmed.2001.1195, 11778799.
27. Chapman RW, Phillips JE, Hipkin RW, Curran AK, Lundell D, Fine JS. CXCR2 antagonists for the treatment of pulmonary disease. Pharmacol Ther 2009, 121:55-68. 10.1016/j.pharmthera.2008.10.005, 19026683.