Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME-LC-MS analysis

Journal of Pharmaceutical Analysis

Volumn 4, Issue 1, 2014, Pages 6-13

  Bojko, Barbara ^a   Wa̧sowicz, Marcin ^b   Pawliszyn, Janusz ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Cardiopulmonary bypass; Direct immersion solid phase microextraction; Heart surgery; LC MS; Metabolomics; Tranexamic acid

Indexed keywords

LINOLEIC ACID; LYSOPHOSPHOLIPID; TRANEXAMIC ACID;

ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; HEART SURGERY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; PLASMA; SOLID PHASE MICROEXTRACTION; SURGICAL PATIENT; THROMBOCYTE AGGREGATION;

EID: 84893206549     PISSN: 20951779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpha.2013.03.002     Document Type: Article

References (47)

1. D. Kell Systems biology, metabolic modelling and metabolomics in drug discovery and development Drug Discovery Today 11 2006 1085 1092
2. E.J. Want, A. Nordstrolm, and H. Morita et al. From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics J. Proteome Res. 6 2007 459 468
3. B. Alvarez-Sanchez, F. Priego-Capote, and M.D. Luque de Castro Metabolomics analysis I. Selection of biological samples and practical aspects preceding sample preparation Trends Anal. Chem. 29 2010 111 119
4. W.B. Dunn, N.J.C. Bailey, and H.E. Johnson Measuring the metabolome: current analytical technologies Analyst 130 2005 606 625
5. B. Alvarez-Sanchez, F. Priego-Capote, and M.D. Luque de Castro Metabolomics analysis II. Preparation of biological samples prior to detection Trends Anal. Chem. 29 2010 120 127
6. R. Bonfiglio, R.C. King, and T.V. Olah et al. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds Rapid Commun. Mass Spectrom. 13 1999 1175 1185
7. J. Pawliszyn Solid Phase Microextraction, Theory and Practice 1997 Wiley-VCH. Inc. New York
8. F.M. Musteata, M.L. Musteata, and J. Pawliszyn Fast in vivo microextraction: a new tool for clinical analysis Clin. Chem. 52 2006 708 715
9. M.B. Heringa, and J.L.M. Hermens Measurement of free concentrations using negligible depletion-solid phase microextraction (nd-SPME) Trends Anal. Chem. 22 2003 575 587
10. F.M. Musteata, and J. Pawliszyn Study of ligand-receptor binding using SPME: investigation of receptor, free, and total ligand concentrations J. Proteome Res. 4 2005 789 800
11. D. Vuckovic, and J. Pawliszyn Automated study of ligand-receptor binding using solid-phase microextraction J. Pharm. Biomed. Anal. 50 2008 550 553
12. D. Vuckovic, and J. Pawliszyn Systematic evaluation of solid-phase microextraction coatings for untargeted metabolomic profiling of biological fluids by liquid chromatography-mass spectrometry Anal. Chem. 83 2011 1944 1954
13. D. Vuckovic, I. de Lannoy, and B. Gien et al. In vivo solid-phase microextraction: capturing the elusive portion of metabolome Angew. Chem. 123 2011 5456 5460
14. B.K. Fiechtner, G.A. Nuttall, and M.E. Johnson et al. Plasma tranexamic acid concentrations during cardiopulmonary bypass Anesth. Analg. 92 2001 1131 1136
15. N.P. Dowd, J.M. Karski, and D.C. Cheng et al. Pharmacokinetics of tranexamic acid during cardiopulmonary bypass Anesthesiology 97 2002 390 399
16. T. Kojima, S. Gando, and Y. Morimoto et al. Systematic elucidation of effects of tranexamic acid on fibrinolysis and bleeding during and after cardiopulmonary bypass surgery Thromb. Res. 104 2001 301 307
17. S. Frank, S. Durovic, and K. Kostner et al. Inhibitors for the in vitro assembly of Lp(a) Arterioscler. Thromb. Vasc. Biol. 15 1995 1774 1780
18. S. Frank, A. Hrzenjak, and K. Kostner et al. Effect of tranexamic acid and δ-aminovaleric acid on lipoprotein(a) metabolism in transgenic mice Biochim. Biophys. Acta 1438 1999 99 110
19. K. Martin, J. Knorr, and T. Breuer et al. Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid J. Cardiothorac. Vasc. Anesth. 25 2011 20 25
20. J.M. Murkin, F. Falter, and J. Granton et al. High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients Anesth. Analg. 110 2010 350 353
21. D. Royson Tranexamic acid in cardiac surgery: is there a cause for concern? Crit. Care 14 2010 194
22. F. Michopoulos, L. Lai, and H. Gika et al. UPLC-MS-based analysis of human plasma for metabonomics using solvent precipitation or solid phase extraction J. Proteome Res. 8 2009 2114 2121
23. Human Metabolome Database, 〈http://www.hmdb.caa.
24. K. Hanasaki, K. Yamada, and S. Yamamoto et al. Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation J. Biol. Chem. 277 2002 29116 29124
25. M. Hacquebard, A. Ducart, and D. Schmartz et al. Changes in plasma LDL and HDL composition in patients undergoing cardiac surgery Lipids 42 2007 1143 1153
26. M. Güvener, I. Ucar, and M. Ozkan et al. Effect of cardiopulmonary bypass on plasma levels of lipoprotein (a) in hypercholesterolemic patients Jpn. Heart J. 42 2001 563 574
27. D.S. Sgoutas, O.M. Lattouf, and D.C. Finlayson et al. Paradoxical response of plasma lipoprotein(a) in patients undergoing cardiopulmonary bypass Atherosclerosis 97 1992 29 36
28. G. Hofer, E. Steyrer, and G.M. Kostner et al. LDL-mediated interaction of Lp[a] with HepG2 cells: a novel fluorescence microscopy approach J. Lipid Res. 38 1997 2411 2421
29. A. Ezratty, D.I. Simon, and J. Loscalzo Lipoprotein(a) binds to human platelets and attenuates plasminogen binding and activation Biochemistry 32 1993 4628 4633
30. Y. Yatomi, F. Ruan, and S. Haomori et al. Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets Blood 86 1995 193 202
31. Y. Yatomi, S. Yamamura, and F. Ruan et al. Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid J. Biol. Chem. 272 1997 5291 5297
32. G. Gueguen, B. Gaige, and J.M. Grevy et al. Structure-activity analysis of the effects of lysophosphatidic acid on platelet aggregation Biochemistry 38 1999 8440 8450
33. S.M. Chung, O.N. Bae, and K.M. Lim et al. Lysophosphatidic acid induces thrombogenic activity through phosphatidylserine exposure and procoagulant microvesicle generation in human erythrocytes Arterioscler. Thromb. Vasc. Biol. 27 2007 414 421
34. M.H. Lee, S.M. Hammad, and A.J. Semler et al. HDL3, but not HDL2, stimulates plasminogen activator inhibitor-1 release from adipocytes - the role of sphingosine-1-phosphate J. Lipid Res. 51 2010 2619 2628
35. C.K. Means, C.Y. Xiao, and Z. Li et al. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury Am. J. Physiol.: Heart Circ. Physiol. 292 2007 H2944 5291
36. C.E. Chalfant, and S. Spiegel Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling J. Cell Sci. 118 2005 4605 4612
37. K. Kawahito, E. Kobayashi, and M. Ohmori et al. Enhanced responsiveness of circulatory neutrophils after cardiopulmonary bypass: increased aggregability and superoxide producing capacity Artif. Organs 24 2000 37 42
38. P. Conlon, M. Stafford-Smith, and W. White et al. Acute renal failure following cardiac surgery Nephrol. Dial. Transplant. 14 1999 1158 1162
39. S. Wan, J.L. LeClerc, and J.L. Vincent Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies Chest 112 1997 676 692
40. S. Ziegeler, A. Raddatz, and A. Schneider et al. Effects of haemofiltration and mannitol treatment on cardiopulmonary-bypass induced immunosuppression Scand. J. Immunol. 69 2009 234 241
41. D.M. Kuhn, and R. Arthur Jr. Dopamine inactivates tryptophan hydroxylase and forms a redox-cycling quinoprotein: possible endogenous toxin to serotonin neurons J. Neurosci. 18 1998 7111 7117
42. N. Marx, T. Bourcier, and G.K. Sukhova PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease Arterioscler. Thromb. Vasc. Biol. 19 1999 546 551
43. O.V. Carcoana, J.P. Mathew, and E. Davis et al. Mannitol and dopamine in patients undergoing cardiopulmonary bypass: a randomized clinical trial Anesth. Analg. 97 2003 1222 1229
44. D.A. Thompson, and B.D. Hammock Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst J. Biosci. 32 2007 279 291
45. M.F. Moghaddam, D.F. Grant, and J.M. Cheek et al. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase Nat. Med. 3 1997 562 566
46. L.A. Mitchell, D.F. Grant, and R.B. Melchert et al. Linoleic acid metabolites act to increase contractility in isolated rat heart Cardiovasc. Toxicol. 2 2001 219 230
47. Y. Totani, Y. Saito, and T. Ishizaki et al. Leukotoxin and its diol induce neutrophil chemotaxis through signal transduction different from that of fMLP Eur. Respir. J. 15 2000 75 79