Doxorubicin-loaded MePEG-PCL nanoparticles for prevention of posterior capsular opacification

Nanomedicine

Volumn 8, Issue 9, 2013, Pages 1415-1428

  Guha, Rajdeep ^a   Chowdhury, Sushovan ^a   Palui, Himangshu ^b   Mishra, Akhilesh ^b   Basak, Samar ^c   Mandal, Tapan Kumar ^b   Hazra, Sarbani ^b   Konar, Aditya ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b WEST BENGAL UNIVERSITY OF ANIMAL AND FISHERY SCIENCES   (India)

^c Disha Eye Hospitals and Res Centre   (India)

Author keywords

MePEG PCL doxorubicin; nanoparticle delivery; posterior capsular opacification

Indexed keywords

DIMETHYL ETHER; DOXORUBICIN; NANOPARTICLE; POLYCAPROLACTONE; ANTINEOPLASTIC AGENT; DRUG CARRIER; MACROGOL DERIVATIVE; METHOXY POLY(ETHYLENE GLYCOL-CO-EPSILON-CAPROLACTONE); POLYESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; CAPSULE OPACIFICATION; CELL DENSITY; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CORNEA CELL; CORNEA ENDOTHELIUM; CYTOTOXICITY; DNA FRAGMENTATION; ELECTRORETINOGRAPHY; ENCAPSULATION; ENDOTHELIUM CELL; EPITHELIUM CELL; EXPERIMENTAL RABBIT; EYE TOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; INTRAOCULAR PRESSURE; LENS; LENS EPITHELIUM; NONHUMAN; PARTICLE SIZE; POSTERIOR CAPSULAR OPACIFICATION; PRIORITY JOURNAL; SPECULAR MICROSCOPY; SURFACE CHARGE; SUSTAINED DRUG RELEASE; ANIMAL; CATARACT; CATARACT EXTRACTION; DRUG EFFECTS; PATHOLOGY; POSTERIOR CAPSULAR RUPTURE, OCULAR; RABBIT;

ANIMALS; ANTINEOPLASTIC AGENTS; CATARACT; CATARACT EXTRACTION; DOXORUBICIN; DRUG CARRIERS; EPITHELIAL CELLS; NANOPARTICLES; POLYESTERS; POLYETHYLENE GLYCOLS; POSTERIOR CAPSULAR RUPTURE, OCULAR; RABBITS;

EID: 84893191940     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.12.175     Document Type: Article

References (25)

1. Kohnen T. Preventing posterior capsule opacification: What have we learned? J. Cataract Refract. Surg. 37, 623-624 (2011).
2. Saika S. TGF-b pathobiology in the eye. Lab. Invest. 86, 106-115 (2006).
3. Awasthi N, Guo S, Wagner BJ. Posterior capsular opacification: A problem reduced but not yet eradicated. Arch. Ophthalmol. 127, 555-562 (2009).
4. Kim SY, Kim JH, Choi JS, Joo CK. Comparison of posterior capsule opacification in rabbits receiving either mitomycin-C or distilled water for sealed-capsule irrigation during cataract surgery. Clin. Experiment. Ophthalmol. 35, 755-758 (2007).
5. Bretton RH, Swearingen A, Kash RL, Cooley R. Use of a polylysine-saporin conjugate to prevent posterior capsule opacification. J. Cataract Refract. Surg. 25, 921-929 (1999).
6. Wu M, Li H, Li S, Zeng J. The effect of liposome encapsulated daunorubicin on rabbit eyes after extracapsular lens extraction. Yan Ke Xue Bao. 16, 189-193 (2000).
7. Geissler FT, Li DW, James ER. Inhibition of lens epithelial cell growth by induction of apoptosis: Potential for prevention of posterior capsule opacification. J. Ocul. Pharmacol. Ther. 17, 587-596 (2001).
8. Legler UF, Apple DJ, Assia EI, Bluestein EC, Castaneda VE, Mowbray SL. Inhibition of posterior capsule opacification: The effect of colchicine in a sustained drug delivery system. J. Cataract Refract. Surg. 19, 462-470 (1993).
9. Totan Y, Yagci R, Erdurmus M, Bayrak R, Hepsen IF. Cyclosporin effectively inhibits posterior capsule opacification after phacoemulsification in rabbits: A preliminary study. Clin. Experiment. Ophthalmol. 36, 62-66 (2008).
10. Abdelwahab MT, Kugelberg M, Zetterstrom C. Irrigation with thapsigargin and various concentrations of 5-fluorouracil in a sealed-capsule irrigation device in young rabbit eyes to prevent after-cataract. Eye (Lond.) 22, 1508-1513 (2008).
11. Abdelwahab MT, Kugelberg M, Kugelberg U, Zetterstrom C. After-cataract evaluation after using balanced salt solution, distilled deionized water, and 5-fluorouracil with a sealed-capsule irrigation device in the eyes of 4-week-old rabbits. J. Cataract Refract. Surg. 32, 1955-1960 (2006).
12. Duncan G, Wang L, Neilson GJ, Wormstone IM. Lens cell survival after exposure to stress in the closed capsular bag. Invest. Ophthalmol. Vis. Sci. 48, 2701-2707 (2007).
13. Diao YY, Li HY, Fu YH, et al.: Doxorubicin-loaded PEG-PCL copolymer micelles enhance cytotoxicity and intracellular accumulation of doxorubicin in adriamycin-resistant tumor cells. Int. J. Nanomedicine 6, 1955-1962 (2011).
14. Inan UU, Ozturk F, Kaynak S, et al.: Prevention of posterior capsule opacification by intraoperative single-dose pharmacologic agents. J. Cataract Refract. Surg. 27, 1079-1087 (2001).
15. Zhao P, Dash AK. A simple HPLC method using a microbore column for the analysis of doxorubicin. J. Pharm. Biomed. Anal. 20, 543-548 (1999).
16. Savic R, Luo L, Eisenberg A, Maysinger D. Micellar nanocontainers distribute to defined cytoplasmic organelles. Science 300, 615-618 (2003).
17. Mansour HM, Sohn MJ, Al-Ghananeem A, DeLuca PP. Materials for pharmaceutical dosage forms: Molecular pharmaceutics and controlled release drug delivery aspects. Int. J. Mol. Sci. 11, 3298-3322 (2010).
18. Tang R, Ji W, Panus D, Palumbo RN, Wang C. Block copolymer micelles with acid-labile ortho ester side-chains: Synthesis, characterization, and enhanced drug delivery to human glioma cells. J. Control. Release 151, 18-27 (2011).
19. Shuai X, Ai H, Nasongkla N, Kim S, Gao J. Micellar carriers based on block copolymers of poly(epsilon-caprolactone) and poly(ethylene glycol) for doxorubicin delivery. J. Control. Release 98, 415-426 (2004).
20. McDonnell PJ, Krause W, Glaser BM. In vitro inhibition of lens epithelial cell proliferation and migration. Ophthalmic Surg. 19, 25-30 (1988).
21. Barza M, Kane A, Baum J. The difficulty of determining the route of intraocular penetration of gentamicin after subconjunctival injection in the rabbit. Invest. Ophthalmol. Vis. Sci. 20, 509-514 (1981).
22. Regnier A. Clinical pharmacology and therapeutics. In: Veterinary Ophthalmology (4th Edition). Gelatt KN (Ed.). Lippincott Williams and Wilkins, PA, USA, 271-287 (2007).
23. Meacock WR, Spalton DJ, Stanford MR. Role of cytokines in the pathogenesis of posterior capsule opacification. Br. J. Ophthalmol. 84, 332-336 (2000).
24. Vernot J, Peyman GA, Gailitis R, Fiscella R, Woodhouse M, Weinberg D. Effects of selected repeated intravitreal chemotherapeutic agents. Int. Ophthalmol. 8, 193-198 (1985).
25. Kimura H, Ogura Y, Moritera T, et al.: Injectable microspheres with controlled drug release for glaucoma filtering surgery. Invest. Ophthalmol. Vis. Sci. 33, 3436-3441 (1992).