Inhibitory effects of recombinant RTS-jerdostatin on integrin α1β1 function during adhesion, migration and proliferation of rat aortic smooth muscle cells and angiogenesis

Toxicon

Volumn 79, Issue , 2014, Pages 45-54

  Bolás, Gema ^a   De Rezende, Flávia Figueiredo ^b   Lorente, Carolina ^a   Sanz, Libia ^a   Eble, Johannes A ^b   Calvete, Juan J ^a  

^a INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

1 1 integrin inhibitor; Angiogenesis; Cell adhesion; Jerdostatin; Recombinant RTS disintegrin

Indexed keywords

COLLAGEN TYPE 4; DISINTEGRIN; JERDOSTATIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 1;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; AORTA MEDIA; ARTICLE; BINDING SITE; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HEART BLOOD VESSEL; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER;

ANGIOGENESIS; CELL ADHESION; JERDOSTATIN; RECOMBINANT RTS DISINTEGRIN; Α1Β1 INTEGRIN INHIBITOR;

ANIMALS; AORTA; CELL ADHESION; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CLONING, MOLECULAR; COLLAGEN; COLLAGEN TYPE IV; CROTALID VENOMS; DISINTEGRINS; DRUG COMBINATIONS; ENDOTHELIAL CELLS; ESCHERICHIA COLI; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTEGRIN ALPHA1BETA1; INTEGRIN ALPHA2BETA1; LAMININ; LECTINS, C-TYPE; MYOCYTES, SMOOTH MUSCLE; NEOVASCULARIZATION, PATHOLOGIC; PROTEOGLYCANS; RATS; RECOMBINANT PROTEINS; VIPER VENOMS; VIPERIDAE;

EID: 84893172148     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2013.12.006     Document Type: Article

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