Brown adipose tissue in humans: Detection and functional analysis using PET (positron emission tomography), MRI (magnetic resonance imaging), and DECT (dual energy computed tomography)

Methods in Enzymology

Volumn 537, Issue , 2014, Pages 141-159

  Borga, Magnus ^a   Virtanen, Kirsi A ^b   Romu, Thobias ^a   Leinhard, Olof Dahlqvist ^a   Persson, Anders ^a,c   Nuutila, Pirjo ^b,d   Enerbäck, Sven ^e  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UNIVERSITY OF TURKU   (Finland)

^c Department of Clinical Immunology and Transfusion Medicine   (Sweden)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Brown adipose tissue; Dual energy computed tomography; Human; Magnetic resonance imaging; Positron emission tomography

Indexed keywords

6 THIA HEPTA DECANOIC ACID F 18; FLUORODEOXYGLUCOSE F 18; GLUCOSE; TRACER; UNCLASSIFIED DRUG;

ARTICLE; BROWN ADIPOSE TISSUE; COMPTON EFFECT; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; DISTRIBUTION VOLUME; DUAL ENERGY COMPUTED TOMOGRAPHY; FATTY ACID METABOLISM; FUNCTIONAL ASSESSMENT; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; IMAGE RECONSTRUCTION; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OXYGEN CONSUMPTION; PHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TISSUE PERFUSION; WATER CONTENT;

BROWN ADIPOSE TISSUE; DUAL ENERGY COMPUTED TOMOGRAPHY; HUMAN; MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY;

ADIPOSE TISSUE, BROWN; HUMANS; MAGNETIC RESONANCE IMAGING; POSITRON-EMISSION TOMOGRAPHY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84893170959     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-411619-1.00008-2     Document Type: Chapter

References (48)

1. R.E. Alvarez, and A. Macovski Energy-selective reconstructions in X-ray computerized tomography Physics in Medicine and Biology 21 1976 733 744
2. S. Baba, H.A. Jacene, J.M. Engles, H. Honda, and R.L. Wahl CT Hounsfield units of brown adipose tissue increase with activation: Preclinical and clinical studies Journal of Nuclear Medicine 51 2010 246 250
3. R.T. Branca, and W.S. Warren In vivo brown adipose tissue detection and characterization using water-lipid intermolecular zero-quantum coherences Magnetic Resonance in Medicine 65 2011 313 319
4. C. Cohade, K.A. Mourtzikos, and R.L. Wahl "USA-Fat": Prevalence is related to ambient outdoor temperature-evaluation with 18F-FDG PET/CT Journal of Nuclear Medicine 44 2003 1267 1270
5. A.M. Cypess, S. Lehman, G. Williams, I. Tal, D. Rodman, and A.B. Goldfine et al. Identification and importance of brown adipose tissue in adult humans The New England Journal of Medicine 360 15 2009 1509 1517
6. T.R. DeGrado, H.H. Coenen, and G. Stöcklin 14(R,S)-[18F]fluoro-6- thia-heptadecanoic acid (FTHA): Evaluation in mouse of a new probe of myocardial utilization of long chain fatty acids Journal of Nuclear Medicine 32 10 1991 1888 1896
7. W.T. Dixon Simple proton spectroscopic imaging Radiology 153 1984 189 194
8. A. Ebert, H. Herzog, G.L. Stöcklin, M.M. Henrich, T.R. DeGrado, and H.H. Coenen et al. Kinetics of 14(R,S)-fluorine-18-fluoro-6-thia-heptadecanoic acid in normal human hearts at rest, during exercise and after dipyridamole injection Journal of Nuclear Medicine 35 1 1994 51 56
9. T.G. Flohr, C.H. McCollough, H. Bruder, M. Petersilka, K. Gruber, and C. Süss et al. First performance evaluation of a dual-source CT (DSCT) system European Radiology 16 2006 256 268
10. G. Hamilton, M. Bydder, D.L. Smith Jr., K.S. Nayak, and H.H. Hu Proper ties of brown and white adipose tissue measured by 1H MRS Journal of Magnetic Resonance Imaging 34 2011 468 473
11. L.M. Ho, T.T. Yoshizumi, L.M. Hurwitz, R.C. Nelson, D. Marin, and G. Toncheva et al. Dual energy versus single energy MDCT: Measurement of radiation dose using adult abdominal imaging protocols Academic Radiology 16 2009 1400 1407
12. H.H. Hu, S.A. Chung, K.S. Nayak, H.A. Jackson, and V. Gilsanz Differential CT attenuation of metabolically active and inactive adipose tissues - Preliminary findings Journal of Computer Assisted Tomography 35 1 2011 65 71
13. H.H. Hu, D.L. Smith Jr., K.S. Nayak, M.I. Goran, and T.R. Nagy Identification of brown adipose tissue in mice with fat-water IDEAL-MRI Journal of Magnetic Resonance Imaging 31 2010 1195 1202
14. H.H. Hu, J.P. Tovar, Z. Pavlova, M.L. Smith, and V. Gilsanz Unequivocal identification of brown adipose tissue in a human infant Journal of Magnetic Resonance Imaging 35 2012 938 942
15. H.H. Hu, L. Yin, P.C. Aggabao, T.G. Perkins, J.M. Chia, and V. Gilsanz Comparison of brown and white adipose tissues in infants and children with chemical-shift-encoded water-fat MRI Journal of Magnetic Resonance Imaging 38 2013 885 896 10.1002/jmri.24053
16. H. Iida, I. Kanno, A. Takahashi, S. Miura, M. Murakami, and K. Takahashi et al. Measurement of absolute myocardial blood flow with H215O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect Circulation 78 1988 104 115
17. T.R. Johnson, B. Krauss, M. Sedlmair, M. Grasruck, H. Bruder, and D. Morhard et al. Material differentiation by dual energy CT: Initial experience European Radiology 17 2007 1510 1517
18. W.A. Kalender, E. Klotz, and L. Kostaridou An algorithm for noise suppression in dual energy CT material density images IEEE Transactions on Medical Imaging 7 1988 218 224
19. W.A. Kalender, E. Klotz, and C. Suess Vertebral bone mineral analysis: An integrated approach with CT Radiology 164 1987 419 423
20. A. Khanna, and R.T. Branca Detecting brown adipose tissue activity with BOLD MRI in mice Magnetic Resonance in Medicine 68 4 2012 1285 1290 10.1002/mrm.24118 (Epub 2012 Jan 9)
21. O.D. Leinhard, A. Johansson, J. Rydell, M. Borga, and P. Lundberg Intensity inhomogeneity correction in two point dixon imaging Proceedings of the international society for magnetic resonance in medicine annual meeting (ISMRM'08) Vol. 16 2008 1519
22. E. Lunati, P. Marzola, E. Nicolato, M. Fedrigo, M. Villa, and A. Sbarbati In vivo quantitative lipidic map of brown adipose tissue by chemical shift imaging at 4.7 Tesla Journal of Lipid Research 40 1999 1395 1400
23. A. Macovski, R.E. Alvarez, J.L. Chan, J.P. Stonestrom, and L.M. Zatz Energy dependent reconstruction in X-ray computerized tomography Computers in Biology and Medicine 6 1976 325 336
24. D. Marin, R.C. Nelson, E. Samei, E.K. Paulson, L.M. Ho, and D.T. Boll et al. Hypervascular liver tumors: Low tube voltage, high tube current multidetector CT during late hepatic arterial phase for detection - Initial clinical experience Radiology 251 2009 771 779
25. O. Muzik, T.J. Mangner, and J.G. Granneman Assessment of oxidative metabolism in brown fat using PET imaging Frontiers in Endocrinology 3 2012 1 7
26. J. Nedergaard, T. Bengtsson, and B. Cannon Unexpected evidence for active brown adipose tissue in adult humans American Journal of Physiology, Endocrinology and Metabolism 293 2007 E444 E452
27. C.K. Ng, R. Soufer, and P.H. McNulty Effect of hyperinsulinemia on myocardial fluorine-18-FDG uptake Journal of Nuclear Medicine 39 3 1998 379 383
28. P. Nuutila, V.A. Koivisto, J. Knuuti, U. Ruotsalainen, M. Teräs, and M. Haaparanta et al. Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo The Journal of Clinical Investigation 89 6 1992 1767 1774
29. J. Orava, P. Nuutila, M.E. Lidell, V. Oikonen, T. Noponen, and T. Viljanen et al. Different metabolic responses of human brown adipose tissue to activation by cold and insulin Cell Metabolism 14 2 2011 272 279
30. D.P. O'Regan, M.F. Callaghan, M. Wylezinska-Arridge, J. Fitzpatrick, R.P. Naoumova, and J.V. Hajnal et al. Liver fat content and T2*: Simultaneous measurement by using breath-hold multiecho MR imaging at 3.0 T - Feasibility Radiology 247 2 2008 550 557
31. V. Ouellet, S.M. Labbé, D.P. Blondin, S. Phoenix, B. Guérin, and F. Haman et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans The Journal of Clinical Investigation 122 2 2012 545 552 10.1172/JCI60433
32. C.S. Patlak, and R.G. Blasberg Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations Journal of Cerebral Blood Flow and Metabolism 5 1985 584 590
33. 18F]fluorodeoxyglucose in skeletal muscles of obese and nonobese humans American Journal of Physiology, Endocrinology and Metabolism 279 2000 E1122 E1130
34. M. Petersilka, H. Bruder, B. Krauss, K. Stierstorfer, and T.G. Flohr Technical principles of dual source CT European Journal of Radiology 68 2008 362 368
35. M.E. Phelps, S.-C. Huang, E.J. Hoffman, C. Selin, L. Sokoloff, and D.E. Kuhl Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-d-glucose: Validation of method Annals of Neurology 6 1979 371 388
36. S.B. Reeder, H.H. Hu, and C.B. Sirlin Proton density fat-fraction: A standardized MR-based biomarker of tissue fat concentration Journal of Magnetic Resonance Imaging 36 2012 1011 1014
37. T. Romu, M. Borga, and O.D. Leinhard MANA - Multi scale adaptive normalized averaging Proceedings of the 2011 IEEE international symposium on biomedical imaging: From nano to macro 2011 361 364
38. T. Romu, O.D. Leinhard, M.F. Forsgren, S. Almer, N. Dahlström, and S. Kechagias et al. Fat water classification of symmetrically sampled two-point dixon images using biased partial volume effects Proceedings of the international society for magnetic resonance in medicine annual meeting (ISMRM'11) 2011
39. U. Ruotsalainen, M. Raitakari, P. Nuutila, V. Oikonen, H. Sipilä, and M. Teräs et al. Quantitative blood flow measurement of skeletal muscle using oxygen-15-water and PET Journal of Nuclear Medicine 38 1997 314 319
40. J. Rydell, A. Johansson, O.D. Leinhard, H. Knutsson, G. Farnebäck, and P. Lundberg et al. Three dimensional phase sensitive reconstruction for water/fat separation in MR imaging using inverse gradient Proceedings of the international society for magnetic resonance in medicine annual meeting (ISMRM'08) 2008 1519
41. J. Rydell, H. Knutsson, J. Pettersson, A. Johansson, G. Farnebäck, and O.D. Leinhard et al. Phase sensitive reconstruction for water/fat separation in MR imaging using inverse gradient Lecture notes in computer science: Vol. 4791. Medical image computing and computer-assisted intervention - MICCAI 2007 2007 210 218
42. M. Saito, Y. Okamatsu-Ogura, M. Matsushita, K. Watanabe, T. Yoneshiro, and J. Nio-Kobayashi et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity Diabetes 58 7 2009 1526 1531
43. L. Sokoloff, M. Reivich, C. Kennedy, M.H. Des Rosiers, C.S. Patlak, and K.D. Pettigrew et al. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat Journal of Neurochemistry 28 1977 897 916
44. W.D. van Marken Lichtenbelt, J.W. Vanhommerig, N.M. Smulders, J.M. Drossaerts, G.J. Kemerink, and N.D. Bouvy et al. Cold-activated brown adipose tissue in healthy men The New England Journal of Medicine 360 2009 1500 1508
45. K.A. Virtanen, M.E. Lidell, J. Orava, M. Heglind, M. Westergren, and T. Niemi et al. Functional brown adipose tissue in healthy adults The New England Journal of Medicine 360 2009 1518 1525
46. K.A. Virtanen, P. Peltoniemi, P. Marjamäki, M. Asola, L. Strindberg, and R. Parkkola et al. Human adipose tissue glucose uptake determined using [(18)F]-fluoro-deoxy-glucose ([(18)F]FDG) and PET in combination with microdialysis Diabetologia 44 12 2001 2171 2179
47. H. Yu, C.A. McKenzie, A. Shimakawa, A.T. Vu, A.C. Brau, and P.J. Beatty et al. Multiecho reconstruction for simultaneous water-fat decomposition and T2* estimation Journal of Magnetic Resonance Imaging 26 4 2007 1153 1161
48. H. Zachrisson, E. Engström, J. Engvall, L. Wigström, Ö. Smedby, and A. Persson Soft tissue discrimination ex vivo by dual energy computed tomography European Journal of Radiology 75 2010 124 128