In vivo brown adipose tissue detection and characterization using water-lipid intermolecular zero-quantum coherences

Magnetic Resonance in Medicine

Volumn 65, Issue 2, 2011, Pages 313-319

  Branca, Rosa T ^a   Warren, Warren S ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

brown adipose tissue; intermolecular zero quantum coherences; white adipose tissue

Indexed keywords

MAMMALS; TISSUE;

ADIPOSE TISSUE; DISTANCE SCALE; OBESE MICE; OLEFINIC PROTONS; QUANTUM COHERENCE; SELECTIVE DETECTION; SPATIAL CORRELATIONS; WHITE ADIPOSE TISSUES;

QUANTUM THEORY;

ALKENE; CARBENE; LIPID; WATER;

ANIMAL MODEL; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; HYDRATION; IN VITRO STUDY; IN VIVO STUDY; INTERMOLECULAR ZERO QUANTUM COHERENCE; LIPID STORAGE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; TISSUE CHARACTERIZATION; WHITE ADIPOSE TISSUE;

EID: 79251563794     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22622     Document Type: Article

References (30)

1. Rothwell NJ, Stock MJ,. A role for brown adipose tissue in diet-induced thermogenesis. Nature 1979; 281: 31-35.
2. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng Y-H, Doria A, Kolodny GM, Kahn CR,. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360: 1509-1517.
3. Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M,. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009; 58: 1526-1531.
4. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JMAFL, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJJ,. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009; 360: 1500-1508.
5. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto N-J, Enerback S, Nuutila P,. Functional brown adipose tissue in healthy adults. N Engl J Med 2009; 360: 1518-1525.
6. Tatsumi M, Engles JM, Ishimori T, Nicely OB, Cohade C, Wahl RL,. Intense 18F-FDG uptake in brown fat can be reduced pharmacologically. J Nucl Med 2004; 45: 1189-1193.
7. Nedergaard J, Bengtsson T, Cannon B,. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007; 293: E444-E452.
8. Yeung HWD, Grewal RK, Gonen M, Schoder H, Larson SM,. Patterns of 18F-FDG uptake in adipose tissue and muscle: a potential source of false-positives for PET. J Nucl Med 2003; 44: 1789-1796.
9. Zancanaro C, Nano R, Marchioro C, Sbarbati A, Boicelli A, Osculati F,. Magnetic resonance spectroscopy investigations of brown adipose tissue and isolated brown adipocytes. J Lipid Res 1994; 35: 2191-2199.
10. Walling BE, Munasinghe J, Berrigan D, Bailey MQ, Simpson RM,. Intra-abdominal fat burden discriminated in vivo using proton magnetic resonance spectroscopy. Obesity 2007; 15: 69-77.
11. Strobel K, van den Hoff J, Pietzsch J,. Localized proton magnetic resonance spectroscopy of lipids in adipose tissue at high spatial resolution in mice in vivo. J Lipid Res 2008; 49: 473-480.
12. 1H NMR at 7 Tesla. J Lipid Res 2008; 49: 2055-2062.
13. 1H-magnetic resonance spectroscopy. Obesity 2006; 14: 405-414.
14. Sbarbati A, Guerrini U, Marzola P, Asperio R, Osculati F,. Chemical shift imaging at 4.7 Tesla of brown adipose tissue. J Lipid Res 1997; 38: 343-347.
15. Lunati E, Marzola P, Nicolato E, Fedrigo M, Villa M, Sbarbati A,. In vivo quantitative lipidic map of brown adipose tissue by chemical shift imaging at 4.7 Tesla. J Lipid Res 1999; 40: 1395-1400.
16. Cavallini I, Marino MA, Tonello C, Marzola P, Nicolato E, Fabene PF, Calderan L, Bernardi P, Asperio RM, Nisoli E, Sbarbati A,. The hydrolipidic ratio in age-related maturation of adipose tissues. Biomed Pharmacother 2006; 60: 139-143.
17. Ailhaud G, Grimaldi P, Negrel R,. Cellular and molecular aspects of adipose tissue development. Annu Rev Nutr 1992; 12: 207-233.
18. Sbarbati A, Morroni M, Zancanaro C, Cinti S,. Rat interscapular brown adipose tissue at different ages: a morphometric study. Int J Obes 1991; 15: 581-587.
19. Hirvonen J, Elfving R,. Depletion of fats from the brown adipose tissue cells of rats dead from cold exposure. Int J Legal Med 1973; 72: 50-55.
20. Hu HH, Smith DL, Nayak KS, Goran MI, Nagy TR,. Identification of brown adipose tissue in mice with fat-water IDEAL-MRI. J Magn Reson Imaging 2010; 31: 1195-1202.
21. Vathyam S, Lee S, Warren WS,. Homogeneous NMR spectra in inhomogeneous fields. Science 1996; 272: 92-96.
22. Bouchard L-S, Rizi RR, Warren SW,. Magnetization structure contrast based on intermolecular multiple-quantum coherences. Magn Reson Med 2002; 48: 973-979.
23. Warren WS, Ahn S, Mescher M, Garwood M, Ugurbil K, Richter W, Rizi RR, Hopkins J, Leigh JS,. MR imaging contrast enhancement based on intermolecular zero quantum coherences. Science 1998; 281: 247-251.
24. Warren WS, Richter W, Andreotti AH, Farmer BT, II,. Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR. Science 1993; 262: 2005-2009.
25. Garrett-Roe S, Warren WS,. Numerical studies of intermolecular multiple quantum coherences: high-resolution NMR in inhomogeneous fields and contrast enhancement in MRI. J Magn Reson 2000; 146: 1-13.
26. Hu HH, Nayak KS,. Change in the proton T1 of fat and water in mixture. Magn Reson Med 2009; 63: 494-501.
27. De Souza J, Butler AA, Cone RD,. Disproportionate inhibition of feeding in Ay mice by certain stressors: a cautionary note. Neuroendocrinology 2000; 72: 126-132.
28. HouÅtÄk J, Holub M,. Cold-induced changes in brown adipose tissue thermogenic capacity of immunocompetent and immunodeficient hairless mice. J Comp Physiol B: Biochem, Syst, Environ Physiol 1994; 164: 459-463.
29. Cannon B, Nedergaard JAN,. Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84: 277-359.
30. Frontini A, Cinti S,. Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab 2010; 11 (4): 253-256.