The interaction of integrin αiIb β3 with fibrin occurs through multiple binding sites in the α IIb β-propeller domain

Journal of Biological Chemistry

Volumn 289, Issue 4, 2014, Pages 2371-2383

  Podolnikova, Nataly P ^a   Yakovlev, Sergiy ^b   Yakubenko, Valentin P ^c   Wang, Xu ^a   Gorkun, Oleg V ^d   Ugarova, Tatiana P ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC RESIDUES; FIBRIN CLOTS; INTEGRINS; MULTIPLE BINDING SITES; NEGATIVELY CHARGED; PLATELET INTEGRIN; RECOGNITION SPECIFICITY; THROMBUS FORMATION;

CELL ADHESION;

PROPELLERS;

ALPHA2B BETA3 INTEGRIN; FIBRIN; FIBRINOGEN; INTEGRIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BLOOD CLOT RETRACTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION;

ADHESION; CLOT RETRACTION; FIBRIN; FIBRINOGEN; INTEGRIN; PLATELETS;

BINDING SITES; BLOOD PLATELETS; FEMALE; FIBRIN; FIBRINOGEN; HEK293 CELLS; HUMANS; INTEGRIN ALPHA2; MACROPHAGE-1 ANTIGEN; MALE; MUTATION; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN STRUCTURE, TERTIARY;

EID: 84893118880     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.518126     Document Type: Article

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