Reduced platelet adhesion in flowing blood to fibrinogen by alterations in segment γ316-322, part of the fibrin-specific region

British Journal of Haematology

Volumn 117, Issue 3, 2002, Pages 650-657

  Remijn, Jasper A ^a   Ijsseldijk, Martin J W ^a   Van Hemel, Bettien M ^a   Galanakis, Dennis K ^b   Hogan, Kelly A ^c   Lounes, Karim C ^c   Lord, Susan T ^c   Sixma, Jan J ^a   De Groot, Philip G ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Dysfibrinogen; Fibrin; Fibrinogen; Flow; Platelet adhesion

Indexed keywords

FIBRIN; FIBRINOGEN; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; BLOOD FLOW; CELL SURFACE; CONTROLLED STUDY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; THROMBOCYTE ADHESION;

ANTIBODIES, MONOCLONAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRIN; FIBRINOGEN; HUMANS; IMMUNOGLOBULIN G; PEPTIDE FRAGMENTS; PLATELET ADHESIVENESS; RECOMBINANT PROTEINS;

EID: 0036108891     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03467.x     Document Type: Article

References (38)

1. Exposure of platelet fibrinogen receptors by ADP and epinephrine
2. Fibrin (ogen) peptide B beta 15-42 inhibits platelet aggregation and fibrinogen binding to activated platelets
3. γ-Chain dysfibrinogenemias: Molecular structure-function relationships of naturally occurring mutations in the γ chain of human fibrinogen
4. The amino acid sequence of the alpha-chain of human fibrinogen
5. Platelet adhesion to fibrin (ogen)
6. Binding of recombinant fibrinogen mutants to platelets
7. Role of fibrinogen alpha and gamma chain sites in platelet aggregation
8. Impaired platelet aggregation support by two dysfibrinogens: A γ319-320 deletion and γ310 Met(r)Thr substitution
9. Characterization of adhesion of 'resting' and stimulated platelets to fibrinogen and its fragments
10. Evidence that fibrin alpha-chain RGDX sequences are not required for platelet adhesion in flowing whole blood
11. Adhesive interactions of blood cells and the vascular wall
12. The residues AGDV of recombinant γ-chains of human fibrinogen must be carboxy-terminal to support human platelet aggregation
13. Recombinant fibrinogen Vlissingen/FrankfurtIV: The deletion of residues 319 and 320 from the γ-chain of fibrinogen alters calcium binding, fibrin polymerization, cross-linking and platelet aggregation
14. A functional assay suggests that heterodimers exist in two C-terminal γ-chain dysfibrinogens: Matsumoto I and Vlissingen/FrankfurtIV
15. Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3
16. Subendothelial proteins and platelet adhesion. Von Willebrand factor and fibronectin, not thrombospondin, are involved in platelet adhesion to extracellular matrix of human vascular endothelial cells
17. Localization of a site interacting with human platelet receptor on carboxy-terminal segment of human fibrinogen γ-chain
18. Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the γ-chain
19. Characterization of soluble polymerized fibrin formed in the presence of excess fibrinogen fragment D
20. A congenitally abnormal fibrinogen (Vlissingen) with a 6-base deletion in the gamma-chain gene, causing defective calcium binding and impaired fibrin polymerization
21. Polymerization site a function dependence on structural integrity of its nearby calcium binding site
22. The subunit polypeptides of human fibrinogen
23. Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation
24. Chemical reactions and equilibrium constants
25. Quantitative and qualitative disorders of fibrinogen
26. The preparation and properties of human fibrinogen of relatively high solubility
27. Evidence for novel binding sites on the platelet glyco-protein IIb and IIIa subunits and immobilized fibrinogen
28. GPIIb-IIIa: The responsive integrin
29. Absence of fibrinogen in afibrinogenemia results in large but loosely packed thombi under flow conditions
30. Platelet-mediated clot retraction is inhibited with antibodies raised against the fibrinogen γ-chain sequences γ308-322 and γ316-333
31. Dissecting clot retraction and platelet aggregation. Clot retraction does not require an intact fibrinogen gamma chain C terminus
32. The contribution of the three hypothesized integrin-binding sites in fibrinogen to platelet-mediated clot retraction
33. New perspectives in cell adhesion: RGD and integrins
34. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on Von Willebrand factor
35. The sequence gamma-(312-324) is a fibrin-specific epitope
36. A monoclonal antibody against a peptide sequence of fibrinogen gamma chain acts as an inhibitor of factor XIII-mediated crosslinking of human fibrin
37. Crystal structure of a 30 kDa C-terminal fragment from the gamma chain of human fibrinogen
38. Adhesion of platelets to surface-bound fibrinogen under flow