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Volumn 22, Issue 1, 2014, Pages 55-61

Inhibition of tnf-α-mediated nf-kb transcriptional activity by dammarane-type ginsenosides from steamed flower buds of panax ginseng in hepg2 and sk-hep1 cells

Author keywords

Hepatocyte derived cells; Nf kb inhibitory activity; Panax ginseng flower buds; Tumor necrosis factor

Indexed keywords

6' ACETYL GINSENOSIDE RG 1; APIGENIN; CXCL1 CHEMOKINE; DAMMARANE DERIVATIVE; GINSENOSIDE; GINSENOSIDE F 1; GINSENOSIDE F 4; GINSENOSIDE MB; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RG 6; GINSENOSIDE RH 4; GINSENOSIDE RK 3; GINSENOSIDE RK 6; GINSENOSIDE RS 4; GINSENOSIDE SF; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; NITRIC OXIDE SYNTHASE; PSEUDOGINSENOSIDE RC 1; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VINAGINSENOSIDE R 4;

EID: 84893074871     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2013.096     Document Type: Article
Times cited : (21)

References (33)
  • 1
    • 0029670627 scopus 로고    scopus 로고
    • Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng
    • Baek, N. I., Kim, D. S., Lee, Y. H., Park, J. D., Lee, C. B. and Kim, S. I. (1996) Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng. Planta Med. 62, 86-87.
    • (1996) Planta Med , vol.62 , pp. 86-87
    • Baek, N.I.1    Kim, D.S.2    Lee, Y.H.3    Park, J.D.4    Lee, C.B.5    Kim, S.I.6
  • 3
    • 50349101675 scopus 로고    scopus 로고
    • Ginsenosides chemistry, biosynthesis, analysis, and potential health effects
    • Christensen, L. P. (2009) Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv. Food Nutr. Res. 55, 1-99.
    • (2009) Adv. Food Nutr. Res , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 4
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis
    • Elsharkawy, A. M. and Mann, D. A. (2007) Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 46, 590-597.
    • (2007) Hepatology , vol.46 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2
  • 5
    • 79951777625 scopus 로고    scopus 로고
    • Panax ginseng: An Overview of the Clinical Evidence
    • Ernst, E. (2010) Panax ginseng: An Overview of the Clinical Evidence. J. Ginseng Res. 34, 259-263.
    • (2010) J. Ginseng Res , vol.34 , pp. 259-263
    • Ernst, E.1
  • 6
    • 78649364685 scopus 로고    scopus 로고
    • Oxidative stress and inducible nitric oxide synthase induction in carcinogenesis
    • Farinati, F., Piciocchi, M., Lavezzo, E., Bortolami, M. and Cardin, R. (2010) Oxidative stress and inducible nitric oxide synthase induction in carcinogenesis. Dig. Dis. 28, 579-584.
    • (2010) Dig. Dis , vol.28 , pp. 579-584
    • Farinati, F.1    Piciocchi, M.2    Lavezzo, E.3    Bortolami, M.4    Cardin, R.5
  • 7
    • 80051896049 scopus 로고    scopus 로고
    • Anti-inflammatory activity of structurally related flavonoids, apigenin, luteolin and fisetin
    • Funakoshi-Tago, M., Nakamura, K., Tago, K., Mashino, T. and Kasahara, T. (2011) Anti-inflammatory activity of structurally related flavonoids, apigenin, luteolin and fisetin. Int. Immunopharmacol. 11, 1150-1159.
    • (2011) Int. Immunopharmacol , vol.11 , pp. 1150-1159
    • Funakoshi-Tago, M.1    Nakamura, K.2    Tago, K.3    Mashino, T.4    Kasahara, T.5
  • 8
    • 84870199424 scopus 로고    scopus 로고
    • NF-κB as a target for modulating inflammatory responses
    • Gasparini, C. and Feldmann, M. (2012) NF-κB as a target for modulating inflammatory responses. Curr. Pharm. Des. 18, 5735-5745
    • (2012) Curr. Pharm. Des , vol.18 , pp. 5735-5745
    • Gasparini, C.1    Feldmann, M.2
  • 9
    • 33845996148 scopus 로고    scopus 로고
    • Inflammation, cancer, and targets of ginseng
    • Hofseth, L. J. and Wargovich, M. J. (2007) Inflammation, cancer, and targets of ginseng. J. Nutr. 137, 183S-185S.
    • (2007) J. Nutr , vol.137
    • Hofseth, L.J.1    Wargovich, M.J.2
  • 11
    • 33745489431 scopus 로고    scopus 로고
    • Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
    • Kawanishi, S., Hiraku, Y., Pinlaor, S. and Ma, N. (2006) Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol. Chem. 387, 365-372.
    • (2006) Biol. Chem , vol.387 , pp. 365-372
    • Kawanishi, S.1    Hiraku, Y.2    Pinlaor, S.3    Ma, N.4
  • 12
    • 0033093123 scopus 로고    scopus 로고
    • Ginsenoside- Rs4, a new type of ginseng saponin concurrently induces apoptosis and selectively elevates protein levels of p53 and p21WAF1 in human hepatoma SK-HEP-1 cells
    • Kim, S. E., Lee, Y. H., Park, J. H. and Lee, S. K. (1999) Ginsenoside- Rs4, a new type of ginseng saponin concurrently induces apoptosis and selectively elevates protein levels of p53 and p21WAF1 in human hepatoma SK-HEP-1 cells. Eur. J. Cancer 35, 507-511.
    • (1999) Eur. J. Cancer , vol.35 , pp. 507-511
    • Kim, S.E.1    Lee, Y.H.2    Park, J.H.3    Lee, S.K.4
  • 13
    • 84866639068 scopus 로고    scopus 로고
    • Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages
    • Lee, I. A., Hyam, S. R., Jang, S. E., Han, M. J. and Kim, D. H. (2012) Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages. J. Agric. Food Chem. 60, 9595-9602
    • (2012) J. Agric. Food Chem , vol.60 , pp. 9595-9602
    • Lee, I.A.1    Hyam, S.R.2    Jang, S.E.3    Han, M.J.4    Kim, D.H.5
  • 14
    • 79958016306 scopus 로고    scopus 로고
    • Anti- complementary ginsenosides isolated from processed ginseng
    • Lee, J. G., Baek, S. H., Lee, Y. Y., Park, S. Y. and Park, J. H. (2011) Anti- complementary ginsenosides isolated from processed ginseng. Biol. Pharm. Bull. 34, 898-900.
    • (2011) Biol. Pharm. Bull , vol.34 , pp. 898-900
    • Lee, J.G.1    Baek, S.H.2    Lee, Y.Y.3    Park, S.Y.4    Park, J.H.5
  • 15
  • 16
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li, Q. and Verma, I. M. (2002) NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2, 725-734.
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 18
    • 77954520406 scopus 로고    scopus 로고
    • NFkappaB: A promising target for natural products in cancer chemoprevention
    • Luqman, S. and Pezzuto, J. M. (2010) NFkappaB: a promising target for natural products in cancer chemoprevention. Phytother. Res. 24, 949-963.
    • (2010) Phytother. Res , vol.24 , pp. 949-963
    • Luqman, S.1    Pezzuto, J.M.2
  • 20
    • 33746862576 scopus 로고    scopus 로고
    • Naturally occurring NF-kappaB inhibitors
    • Nam, N. H. (2006) Naturally occurring NF-kappaB inhibitors. Mini Rev. Med. Chem. 6, 945-951.
    • (2006) Mini Rev. Med. Chem , vol.6 , pp. 945-951
    • Nam, N.H.1
  • 21
    • 51449106903 scopus 로고    scopus 로고
    • Anti-metastatic potential of ginsenoside Rp1, a novel ginsenoside derivative
    • Park, T. Y., Park, M. H., Shin, W. C., Rhee, M. H., Seo, D. W., Cho, J. Y. and Kim, H. M. (2008) Anti-metastatic potential of ginsenoside Rp1, a novel ginsenoside derivative. Biol. Pharm. Bull. 31, 1802-1805.
    • (2008) Biol. Pharm. Bull , vol.31 , pp. 1802-1805
    • Park, T.Y.1    Park, M.H.2    Shin, W.C.3    Rhee, M.H.4    Seo, D.W.5    Cho, J.Y.6    Kim, H.M.7
  • 22
    • 84859615207 scopus 로고    scopus 로고
    • Inhibition of TNF-α-mediated NF-κB transcriptional activity in HepG2 cells by dammarane-type saponins from Panax ginseng leaves
    • Song, S. B., Tung, N. H., Quang, T. H., Ngan, N. T., Kim, K. E. and Kim, Y. H. (2012) Inhibition of TNF-α-mediated NF-κB transcriptional activity in HepG2 cells by dammarane-type saponins from Panax ginseng leaves. J. Ginseng Res. 36, 146-152.
    • (2012) J. Ginseng Res , vol.36 , pp. 146-152
    • Song, S.B.1    Tung, N.H.2    Quang, T.H.3    Ngan, N.T.4    Kim, K.E.5    Kim, Y.H.6
  • 24
    • 78751648222 scopus 로고    scopus 로고
    • Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells
    • Toh, D. F., Patel, D. N., Chan, E. C., Teo, A., Neo, S. Y. and Koh, H. L. (2011) Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells. Chin. Med. 6, 4.
    • (2011) Chin. Med , vol.6 , pp. 4
    • Toh, D.F.1    Patel, D.N.2    Chan, E.C.3    Teo, A.4    Neo, S.Y.5    Koh, H.L.6
  • 25
    • 71649090822 scopus 로고    scopus 로고
    • Two new dammarane-type saponins from the leaves of Panax ginseng
    • Tung, N. H., Song, G. Y., Park, Y. J. and Kim, Y. H. (2009) Two new dammarane-type saponins from the leaves of Panax ginseng. Chem. Pharm. Bull. (Tokyo) 57, 1412-1414.
    • (2009) Chem. Pharm. Bull. (Tokyo) , vol.57 , pp. 1412-1414
    • Tung, N.H.1    Song, G.Y.2    Park, Y.J.3    Kim, Y.H.4
  • 27
    • 77952620373 scopus 로고    scopus 로고
    • Dammarane-type glycosides from the steamed flower-buds of Panax ginseng
    • Tung, N. H., Cho, K., Kim, J. A., Song, G. Y. and Kim, Y. H. (2010b) Dammarane-type glycosides from the steamed flower-buds of Panax ginseng. Bull. Korean Chem. Soc. 31, 1381-1384.
    • (2010) Bull. Korean Chem. Soc , vol.31 , pp. 1381-1384
    • Tung, N.H.1    Cho, K.2    Kim, J.A.3    Song, G.Y.4    Kim, Y.H.5
  • 28
    • 72049084474 scopus 로고    scopus 로고
    • Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia Cells
    • Tung, N. H., Song, G. Y., Kim, J. A., Hyun, J. H., Kang, H. K. and Kim, Y. H. (2010c) Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia Cells. Bioorg. Med. Chem. Lett. 20, 309-314.
    • (2010) Bioorg. Med. Chem. Lett , vol.20 , pp. 309-314
    • Tung, N.H.1    Song, G.Y.2    Kim, J.A.3    Hyun, J.H.4    Kang, H.K.5    Kim, Y.H.6
  • 30
    • 79960434339 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenosides from steamed ginseng-leaves and flowers on the LPSstimulated IL-12 production in bone marrow-derived dendritic cells
    • Tung, N. H., Quang, T. H., Son, J. H., Koo, J. E., Hong, H. J., Koh, Y. S., Song, G. Y. and Kim, Y. H. (2011) Inhibitory effect of ginsenosides from steamed ginseng-leaves and flowers on the LPSstimulated IL-12 production in bone marrow-derived dendritic cells. Arch. Pharm. Res. 34, 681-685.
    • (2011) Arch. Pharm. Res , vol.34 , pp. 681-685
    • Tung, N.H.1    Quang, T.H.2    Son, J.H.3    Koo, J.E.4    Hong, H.J.5    Koh, Y.S.6    Song, G.Y.7    Kim, Y.H.8
  • 31
    • 79951793310 scopus 로고    scopus 로고
    • Current clinical evidence for Korean red ginseng in management of diabetes and vascular disease: A Toronto's ginseng clinical testing program
    • Vuksan, V., Sievenpipper, J., Jovanovski, E. and Jenkins, A. L. (2010) Current clinical evidence for Korean red ginseng in management of diabetes and vascular disease: a Toronto's ginseng clinical testing program. J. Ginseng Res. 34, 264-273.
    • (2010) J. Ginseng Res , vol.34 , pp. 264-273
    • Vuksan, V.1    Sievenpipper, J.2    Jovanovski, E.3    Jenkins, A.L.4
  • 32
    • 70450278777 scopus 로고    scopus 로고
    • Ginseng leaf-stem: Bioactive constituents and pharmacological functions
    • Wang, H., Peng, D. and Xie, J. (2009) Ginseng leaf-stem: bioactive constituents and pharmacological functions. Chin. Med. 4, 20.
    • (2009) Chin. Med , vol.4 , pp. 20
    • Wang, H.1    Peng, D.2    Xie, J.3


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