Vanilloid Receptor-1 (TRPV1) Expression and Function in the Vasculature of the Rat

Journal of Histochemistry and Cytochemistry

Volumn 62, Issue 2, 2014, Pages 129-144

  Tóth, Attila ^a   Czikora, Ágnes ^a   Pásztor, Eniko T ^a   Dienes, Beatrix ^a   Bai, Péter ^a   Csernoch, László ^a   Rutkai, Ibolya ^a   Csató, Viktória ^b   Mányiné, Ivetta S ^a   Pórszász, Róbert ^a   Édes, István ^a   Papp, Zoltán ^a   Boczán, Judit ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b NONE

Author keywords

arteriolar constriction; capsaicin; dorsal root ganglia; functional; resistance artery; vanilloid receptor 1 (TRPV1); vascular biology

Indexed keywords

CAPSAICIN; NORADRENALIN; RNA; SMOOTH MUSCLE ACTIN; THROMBOXANE A2 RECEPTOR STIMULATING AGENT; VANILLOID RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL; CAROTID ARTERY; CELL STRAIN HEK293; CONTROLLED STUDY; FEMORAL ARTERY; IMMUNOHISTOCHEMISTRY; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE CELL; SKELETAL MUSCLE; SMOOTH MUSCLE FIBER; SPINAL GANGLION; VASCULAR SMOOTH MUSCLE; VASCULAR TISSUE; VASCULARIZATION;

ARTERIOLAR CONSTRICTION; CAPSAICIN; DORSAL ROOT GANGLIA; FUNCTIONAL; RESISTANCE ARTERY; VANILLOID RECEPTOR-1 (TRPV1); VASCULAR BIOLOGY;

ANIMALS; ARTERIES; CAPSAICIN; GANGLIA, SPINAL; MALE; MESENTERY; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCLE, SMOOTH, VASCULAR; NERVE TISSUE; ORGAN SPECIFICITY; RATS; RATS, INBRED WKY; SKIN; SPINAL CORD; TRPV CATION CHANNELS; VEINS;

EID: 84893070298     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/0022155413513589     Document Type: Article

References (21)

1. Bai P,Houten SM,Huber A,Schreiber V,Watanabe M,Kiss B,de Murcia G,Auwerx J,Ménissier-de Murcia J.Poly(ADP-ribose) polymerase-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma heterodimer.J Biol Chem. 2007;282:37738-37746.
2. Baylie RL,Brayden JE.TRPV channels and vascular function.Acta Physiol. 2011;203:99-116.
3. Cavanaugh DJ,Chesler AT,Jackson AC,Sigal YM,Yamanaka H,Grant R,O'Donnell D,Nicoll RA,Shah NM,Julius D,Basbaum AI.Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells.J Neurosci. 2011;31:5067-5077.
4. Czikora Á,Lizanecz E,Bakó P,Rutkai I,Ruzsnavszky F,Magyar J,Pórszász R,Kark T,Facskó A,Papp Z,Edes I,Tóth A.Structure-activity relationships of vanilloid receptor agonists for arteriolar TRPV1.Br J Pharmacol. 2012;165:1801-1812.
5. Davidson EP,Coppey LJ,Yorek MA.Activity and expression of the vanilloid receptor 1 (TRPV1) is altered by long-term diabetes in epineurial arterioles of the rat sciatic nerve.Diabetes Metab Res. 2006;22:211-219.
6. Donnerer J,Lembeck F.Analysis of the effects of intravenously injected capsaicin in the rat.Naunyn Schmiedebergs Arch Pharmacol. 1982;320:54-57.
7. Duckles SP.Effects of capsaicin on vascular smooth muscle.Naunyn Schmiedebergs Arch Pharmacol. 1986;333:59-64.
8. Eilers H,Lee S-Y,Hau CW,Logvinova A,Schumacher MA.The rat vanilloid receptor splice variant VR.5'sv blocks TRPV1 activation.Neuroreport. 2007;18:969-973.
9. Gavva NR.Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1.Trends Pharmacol Sci. 2008;29:550-557.
10. Holzer P.The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor.Brit J Pharmacol. 2008;155:1145-1162.
11. Kark T,Bagi Z,Lizanecz E,Pásztor ET,Erdei N,Czikora Á,Papp Z,Edes I,Pórszász R,Tóth A.Tissue-specific regulation of microvascular diameter: opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1.Mol Pharmacol. 2008;73:1405-1412.
12. Lizanecz E,Bagi Z,Pásztor ET,Papp Z,Edes I,Kedei N,Blumberg PM,Tóth A.Phosphorylation-dependent desensitization by anandamide of vanilloid receptor-1 (TRPV1) function in rat skeletal muscle arterioles and in Chinese hamster ovary cells expressing TRPV1.Mol Pharmacol. 2006;69:1015-1023.
13. Martin E,Dahan D,Cardouat G,Gillibert-Duplantier J,Marthan R,Savineau J-P,Ducret T.Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells.Pflug Arch Eur J Phy. 2012;464:261-272.
14. Szallasi A,Blumberg PM.Vanilloid (Capsaicin) receptors and mechanisms.Pharmacol Rev. 1999;51:159-212.
15. Szallasi A,Sheta M.Targeting TRPV1 for pain relief: limits, losers and laurels. Expert Opin Investig Drugs. 2012;21:1351-1369.
16. Tian W,Fu Y,Wang DH,Cohen DM.Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant.Am J Physiol Renal. 2006;290:F117-126.
17. Tominaga M,Caterina MJ,Malmberg AB,Rosen TA,Gilbert H,Skinner K,Raumann BE,Basbaum AI,Julius D.The cloned capsaicin receptor integrates multiple pain-producing stimuli.Neuron. 1998;21:531-543.
18. Toth A,Boczan J,Kedei N,Lizanecz E,Bagi Z,Papp Z,Edes I,Csiba L,Blumberg PM.Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain.Brain Res Mol Brain Res. 2005;135:162-168.
19. Vos MH,Neelands TR,McDonald HA,Choi W,Kroeger PE,Puttfarcken PS,Faltynek CR,Moreland RB,Han P.TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells.J Neurochem. 2006;99:1088-1102.
20. Wang C,Hu H-Z,Colton CK,Wood JD,Zhu MX.An alternative splicing product of the murine trpv1 gene dominant negatively modulates the activity of TRPV1 channels.J Biol Chem. 2004;279:37423-7430.
21. Zygmunt PM,Petersson J,Andersson DA,Chuang H,Sørgård M,Di Marzo V,Julius D,Högestätt ED.Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide.Nature. 1999;400:452-457.