Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation

Heart Rhythm

Volumn 11, Issue 2, 2014, Pages 246-251

  Olesen, Morten S ^a,b,c   Andreasen, Laura ^a,b,c   Jabbari, Javad ^a,b   Refsgaard, Lena ^a,b,c   Haunsø, Stig ^a,b,c   Olesen, Søren Peter ^a,c   Nielsen, Jonas B ^a,b,c   Schmitt, Nicole ^a,c   Svendsen, Jesper H ^a,b,c  

^a DANISH NATIONAL RESEARCH FOUNDATION   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Exome Variant Server; Genetics; Lone AF; Rare variants; Single nucleotide polymorphisms

Indexed keywords

ANP PROTEIN; GENOMIC DNA; GJA5 PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; ION CHANNEL; POTASSIUM CHANNEL KCND3; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNE2; POTASSIUM CHANNEL KCNE5; POTASSIUM CHANNEL KCNH2; POTASSIUM CHANNEL KCNJ2; POTASSIUM CHANNEL KCNQ1; POTASSIUM CHANNEL KV1.5; PROTEIN; SODIUM CHANNEL NAV1.5; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL BETA 1 SUBUNIT; VOLTAGE GATED SODIUM CHANNEL BETA 2 SUBUNIT; VOLTAGE GATED SODIUM CHANNEL BETA 3 SUBUNIT;

ADOLESCENT; ADULT; ALLELE; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; EARLY ONSET LONE ATRIAL FIBRILLATION; EXOME; FAMILY HISTORY; FEMALE; GAIN OF FUNCTION MUTATION; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEART ATRIUM FIBRILLATION; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART REPOLARIZATION; HUMAN; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; ONSET AGE; PATCH CLAMP TECHNIQUE; PATHOGENICITY; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; REFERENCE DATABASE; YOUNG ADULT;

AF; ATRIAL FIBRILLATION; EVS; EXOME VARIANT SERVER; GENETICS; LONE AF; MAF; MINOR ALLELE FREQUENCY; NEXT GENERATION SEQUENCING; NGS; ODDS RATIO; OR; RARE VARIANTS; SINGLE NUCLEOTIDE POLYMORPHISMS;

ADULT; AGE OF ONSET; ALLELES; ATRIAL FIBRILLATION; EXOME; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84893069849     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2013.10.034     Document Type: Article

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