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Volumn 8, Issue 1, 2014, Pages 111-117

The role of epidermal growth factor receptor in prognosis and treatment of gastric cancer

Author keywords

epidermal growth factor receptor; gastric cancer; prognosis; target therapy

Indexed keywords

CAPECITABINE; CETUXIMAB; CISPLATIN; DACOMITINIB; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIRUBICIN; ERLOTINIB; FIGITUMUMAB; FIRTECAN; FLUOROURACIL; FOLINIC ACID; GEFITINIB; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MONOCLONAL ANTIBODY; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; OXALIPLATIN; PACLITAXEL; PANITUMUMAB; PERTUZUMAB; PF 04691502; PLATINUM DERIVATIVE; PROTEIN TYROSINE KINASE INHIBITOR; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 84893057569     PISSN: 17474124     EISSN: 17474132     Source Type: Journal    
DOI: 10.1586/17474124.2014.844648     Document Type: Review
Times cited : (22)

References (61)
  • 2
    • 79959732370 scopus 로고    scopus 로고
    • The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer
    • Yarom N, Jonker DJ. The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer. Discov. Med. 11(57), 95-105 (2011
    • (2011) Discov. Med , vol.11 , Issue.57 , pp. 95-105
    • Yarom, N.1    Jonker, D.J.2
  • 3
    • 84862987061 scopus 로고    scopus 로고
    • Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: Preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer
    • Weickhardt AJ, Price TJ, Chong G et al. Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: Preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer. J. Clin. Oncol. 30(13), 1505-1512 (2012
    • (2012) J. Clin. Oncol , vol.30 , Issue.13 , pp. 1505-1512
    • Weickhardt, A.J.1    Price, T.J.2    Chong, G.3
  • 4
    • 84875720245 scopus 로고    scopus 로고
    • Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer
    • Welsh JW, Komaki R, Amini A et al. Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer. J. Clin. Oncol. 31(7), 895-902 (2013
    • (2013) J. Clin. Oncol , vol.31 , Issue.7 , pp. 895-902
    • Welsh, J.W.1    Komaki, R.2    Amini, A.3
  • 5
    • 84862181925 scopus 로고    scopus 로고
    • Targeting the egfr-family for therapy: Biological challenges and clinical perspective
    • Patel R, Leung HY. Targeting the EGFR-family for therapy: Biological challenges and clinical perspective. Curr. Pharm. Des. 18(19), 2672-2679 (2012
    • (2012) Curr. Pharm. Des , vol.18 , Issue.19 , pp. 2672-2679
    • Patel, R.1    Leung, H.Y.2
  • 6
    • 84860803116 scopus 로고    scopus 로고
    • Targeting egfr in pancreatic cancer treatment
    • Troiani T, Martinelli E, Capasso A et al. Targeting EGFR in pancreatic cancer treatment. Curr. Drug Targets. 13(6), 802-810 (2012
    • (2012) Curr. Drug Targets , vol.13 , Issue.6 , pp. 802-810
    • Troiani, T.1    Martinelli, E.2    Capasso, A.3
  • 8
    • 84874180366 scopus 로고    scopus 로고
    • Egfr and downstream genetic alterations in kras/braf and pi3k/akt pathways in colorectal cancer: Implications for targeted therapy
    • Berg M, Soreide K. EGFR and downstream genetic alterations in KRAS/BRAF and PI3K/AKT pathways in colorectal cancer: Implications for targeted therapy. Discov. Med. 14(76), 207-214 (2012
    • (2012) Discov. Med , vol.14 , Issue.76 , pp. 207-214
    • Berg, M.1    Soreide, K.2
  • 9
    • 51649108116 scopus 로고    scopus 로고
    • Targeting VEGF EGFR, and other interacting pathways for gastric cancer-promises and reality
    • Liakakos T, Fatourou E, Ziogas D, Lykoudis E, Roukos DH. Targeting VEGF, EGFR, and other interacting pathways for gastric cancer-promises and reality. Ann. Surg. Oncol. 15(10), 2981-2982 (2008
    • (2008) Ann. Surg. Oncol , vol.15 , Issue.10 , pp. 2981-2982
    • Liakakos, T.1    Fatourou, E.2    Ziogas, D.3    Lykoudis, E.4    Roukos, D.H.5
  • 11
    • 79961024637 scopus 로고    scopus 로고
    • Targeting the human EGFR family in esophagogastric cancer
    • Okines A, Cunningham D, Chau I. Targeting the human EGFR family in esophagogastric cancer. Nat. Rev. Clin. Oncol. 8(8), 492-503 (2011
    • (2011) Nat. Rev. Clin. Oncol , vol.8 , Issue.8 , pp. 492-503
    • Okines, A.1    Cunningham, D.2    Chau, I.3
  • 12
    • 0037795412 scopus 로고    scopus 로고
    • Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer
    • García I, Vizoso F, Martín A et al. Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer. Ann. Surg. Oncol. 10(3), 234-241 (2003
    • (2003) Ann. Surg. Oncol , vol.10 , Issue.3 , pp. 234-241
    • García, I.1    Vizoso, F.2    Martín, A.3
  • 13
    • 33645761156 scopus 로고    scopus 로고
    • Clinical implications of EGFR expression in the development and progression of solid tumors: Focus on non-small cell lung cancer
    • Ettinger DS. Clinical implications of EGFR expression in the development and progression of solid tumors: Focus on non-small cell lung cancer. Oncologist 11(4), 358-373 (2006
    • (2006) Oncologist , vol.11 , Issue.4 , pp. 358-373
    • Ettinger, D.S.1
  • 14
    • 55949117201 scopus 로고    scopus 로고
    • The growth inhibitory effect of lapatinib, a dual inhibitor of egfr and her2 tyrosine kinase, in gastric cancer cell lines
    • Kim JW, Kim HP, Im SA et al. The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines. Cancer Lett. 272(2), 296-306 (2008
    • (2008) Cancer Lett , vol.272 , Issue.2 , pp. 296-306
    • Kim, J.W.1    Kim, H.P.2    Im, S.A.3
  • 15
    • 79551626045 scopus 로고    scopus 로고
    • Prognostic value of co-expression of STAT3, mTOR and EGFR in gastric cancer
    • Inokuchi M, Murayama T, Hayashi M et al. Prognostic value of co-expression of STAT3, mTOR and EGFR in gastric cancer. Exp. Ther. Med. 2(2), 251-256 (2011
    • (2011) Exp. Ther. Med , vol.2 , Issue.2 , pp. 251-256
    • Inokuchi, M.1    Murayama, T.2    Hayashi, M.3
  • 16
    • 84868560972 scopus 로고    scopus 로고
    • Impact of expression of human epidermal growth factor receptors EGFR and ERBB2 on survival in stage II/III gastric cancer
    • Terashima M, Kitada K, Ochiai A et al. Impact of expression of human epidermal growth factor receptors EGFR and ERBB2 on survival in stage II/III gastric cancer. Clin. Cancer Res. 18(21), 5992-6000 (2012
    • (2012) Clin. Cancer Res , vol.18 , Issue.21 , pp. 5992-6000
    • Terashima, M.1    Kitada, K.2    Ochiai, A.3
  • 17
    • 38049177080 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (vegf) and epidermal growth factor receptor (egfr) is an independent prognostic indicator of worse outcome in gastric cancer patients
    • Lieto E, Ferraraccio F, Orditura M et al. Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients. Ann. Surg. Oncol. 15(1), 69-79 (2008
    • (2008) Ann. Surg. Oncol , vol.15 , Issue.1 , pp. 69-79
    • Lieto, E.1    Ferraraccio, F.2    Orditura, M.3
  • 18
    • 84868703338 scopus 로고    scopus 로고
    • The prognostic impact of epidermal growth factor receptor in patients with metastatic gastric cancer
    • Atmaca A, Werner D, Pauligk C et al. The prognostic impact of epidermal growth factor receptor in patients with metastatic gastric cancer. BMC Cancer 12, 524 (2012
    • (2012) BMC Cancer , vol.12 , pp. 524
    • Atmaca, A.1    Werner, D.2    Pauligk, C.3
  • 19
    • 49649101837 scopus 로고    scopus 로고
    • Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer
    • Matsubara J, Yamada Y, Hirashima Y et al. Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer. Clin. Cancer Res. 14(10), 3022-3029 (2008
    • (2008) Clin. Cancer Res , vol.14 , Issue.10 , pp. 3022-3029
    • Matsubara, J.1    Yamada, Y.2    Hirashima, Y.3
  • 20
    • 84891630858 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptors in gastric cancer: A survival analysis by weibull model incorporating long-Term survivors
    • doi:10.1007/ s10120-013-0236-z 2013 Epub ahead of print
    • Jácome AA, Wohnrath DR, Scapulatempo Neto C et al. Prognostic value of epidermal growth factor receptors in gastric cancer: A survival analysis by Weibull model incorporating long-Term survivors. Gastric Cancer. (doi:10.1007/ s10120-013-0236-z) (2013) (Epub ahead of print
    • Gastric Cancer
    • Jácome, A.A.1    Wohnrath, D.R.2    Scapulatempo Neto, C.3
  • 21
    • 84875551505 scopus 로고    scopus 로고
    • Association among polymorphisms in EGFR gene exons, lifestyle and risk of gastric cancer with gender differences in Chinese han subjects
    • Zhang J, Zhan Z, Wu J et al. Association among polymorphisms in EGFR gene exons, lifestyle and risk of gastric cancer with gender differences in Chinese han subjects. PLoS One 8(3), e59254 (2013
    • (2013) PLoS One , vol.8 , Issue.3
    • Zhang, J.1    Zhan, Z.2    Wu, J.3
  • 22
    • 77949630161 scopus 로고    scopus 로고
    • Epidermal growth factor receptor intron 1 ca dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified folfox6
    • Han SW, Oh DY, Im SA et al. Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6. Cancer Sci. 101(3), 793-799 (2010
    • (2010) Cancer Sci , vol.101 , Issue.3 , pp. 793-799
    • Han, S.W.1    Oh, D.Y.2    Im, S.A.3
  • 24
    • 79960682968 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutation in gastric cancer
    • Liu Z, Liu L, Li M et al. Epidermal growth factor receptor mutation in gastric cancer. Pathology. 43(3), 234-238 (2011
    • (2011) Pathology , vol.43 , Issue.3 , pp. 234-238
    • Liu, Z.1    Liu, L.2    Li, M.3
  • 25
    • 33749331617 scopus 로고    scopus 로고
    • Acetylsalicylic acid enhances antiproliferative effects of the egfr inhibitor gefitinib in the absence of activating mutations in gastric cancer
    • Becker JC, Müller-Tidow C, Stolte M et al. Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer. Int. J. Oncol. 29(3), 615-623 (2006
    • (2006) Int. J. Oncol , vol.29 , Issue.3 , pp. 615-623
    • Becker, J.C.1    Müller-Tidow, C.2    Stolte, M.3
  • 26
    • 84865771639 scopus 로고    scopus 로고
    • Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer
    • Sakamoto N, Oue N, Sentani K et al. Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer. Cancer Sci. 103(9), 1744-1750 (2012
    • (2012) Cancer Sci , vol.103 , Issue.9 , pp. 1744-1750
    • Sakamoto, N.1    Oue, N.2    Sentani, K.3
  • 27
    • 0033194483 scopus 로고    scopus 로고
    • Antisense epidermal growth factor receptor delivered by adenoviral vector blocks tumor growth in human gastric cancer
    • Hirao T, Sawada H, Koyama F et al. Antisense epidermal growth factor receptor delivered by adenoviral vector blocks tumor growth in human gastric cancer. Cancer Gene Ther. 6(5), 423-427 (1999
    • (1999) Cancer Gene Ther , vol.6 , Issue.5 , pp. 423-427
    • Hirao, T.1    Sawada, H.2    Koyama, F.3
  • 28
    • 84876178102 scopus 로고    scopus 로고
    • Pkg ii inhibits egf/egfr-induced migration of gastric cancer cells
    • Jiang L, Lan T, Chen Y et al. PKG II Inhibits EGF/EGFR-Induced Migration of Gastric Cancer Cells. PLoS One 8(4), e61674 (2013
    • (2013) PLoS One , vol.8 , Issue.4
    • Jiang, L.1    Lan, T.2    Chen, Y.3
  • 29
    • 63749101351 scopus 로고    scopus 로고
    • Targeting the egfr and the pkb pathway in cancer
    • Klein S, Levitzki A. Targeting the EGFR and the PKB pathway in cancer. Curr. Opin. Cell Biol. 21(2), 185-193 (2009
    • (2009) Curr. Opin. Cell Biol , vol.21 , Issue.2 , pp. 185-193
    • Klein, S.1    Levitzki, A.2
  • 31
    • 84858156041 scopus 로고    scopus 로고
    • Landscape of egfr signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations
    • Han W, Lo HW. Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations. Cancer Lett. 318(2), 124-134 (2012
    • (2012) Cancer Lett , vol.318 , Issue.2 , pp. 124-134
    • Han, W.1    Lo, H.W.2
  • 32
    • 84880863452 scopus 로고    scopus 로고
    • Dominant negative epidermal growth factor receptor inhibits growth of human gastric cancer cells by inducing cell cycle arrest and apoptosis
    • doi:10.1089/cbr.2012.1399 2013 Epub ahead of print
    • Liao G, Wang Z, Zhang N, Dong P. Dominant negative epidermal growth factor receptor inhibits growth of human gastric cancer cells by inducing cell cycle arrest and apoptosis. Cancer Biother. Radiopharm. (doi:10.1089/cbr.2012. 1399) (2013) (Epub ahead of print
    • Cancer Biother. Radiopharm
    • Liao, G.1    Wang, Z.2    Zhang, N.3    Dong, P.4
  • 33
    • 77950830700 scopus 로고    scopus 로고
    • Inhibitory effects of cytoplasmic-domain substituted epidermal growth factor receptor on growth, invasion and angiogenesis in human gastric cancer cells
    • Liao G, Wang Z, Zhao L, Zhang N, Dong P. Inhibitory effects of cytoplasmic-domain substituted epidermal growth factor receptor on growth, invasion and angiogenesis in human gastric cancer cells. Mol. Med. Rep. 3(2), 287-294 (2010
    • (2010) Mol. Med. Rep , vol.3 , Issue.2 , pp. 287-294
    • Liao, G.1    Wang, Z.2    Zhao, L.3    Zhang, N.4    Dong, P.5
  • 34
    • 33745714777 scopus 로고    scopus 로고
    • Protease-Activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-Activation and proliferation
    • Caruso R, Pallone F, Fina D et al. Protease-Activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-Activation and proliferation. Am. J. Pathol. 169(1), 268-278 (2006
    • (2006) Am. J. Pathol , vol.169 , Issue.1 , pp. 268-278
    • Caruso, R.1    Pallone, F.2    Fina, D.3
  • 35
    • 84873935435 scopus 로고    scopus 로고
    • Crosstalk between egfr and integrin affects invasion and proliferation of gastric cancer cell line sgc7901
    • Dan L, Jian D, Na L, Xiaozhong W. Crosstalk between EGFR and integrin affects invasion and proliferation of gastric cancer cell line, SGC7901. Onco Targets Ther. 5, 271-277 (2012
    • (2012) Onco Targets Ther , vol.5 , pp. 271-277
    • Dan, L.1    Jian, D.2    Na, L.3    Xiaozhong, W.4
  • 36
    • 84867566274 scopus 로고    scopus 로고
    • Targetting esophageal and gastric cancers with monoclonal antibodies
    • Norguet E, Dahan L, Seitz JF. Targetting esophageal and gastric cancers with monoclonal antibodies. Curr. Top. Med. Chem. 12(15), 1678-1682 (2012
    • (2012) Curr. Top. Med. Chem , vol.12 , Issue.15 , pp. 1678-1682
    • Norguet, E.1    Dahan, L.2    Seitz, J.F.3
  • 37
    • 84863101033 scopus 로고    scopus 로고
    • Relevance of met activation and genetic alterations of kras and e-cadherin for cetuximab sensitivity of gastric cancer cell lines
    • doi:10.1007/s00432-011-1128-4 Epub ahead of print
    • Heindl S, Eggenstein E, Keller S et al. Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines. J. Cancer Res. Clin. Oncol. (doi:10.1007/s00432-011-1128-4) (2012) (Epub ahead of print
    • (2012) J. Cancer Res. Clin. Oncol
    • Heindl, S.1    Eggenstein, E.2    Keller, S.3
  • 38
    • 84863576730 scopus 로고    scopus 로고
    • Association of amphiregulin with the cetuximab sensitivity of gastric cancer cell lines
    • Kneissl J, Keller S, Lorber T et al. Association of amphiregulin with the cetuximab sensitivity of gastric cancer cell lines. Int. J. Oncol. 41(2), 733-744 (2012
    • (2012) Int. J. Oncol , vol.41 , Issue.2 , pp. 733-744
    • Kneissl, J.1    Keller, S.2    Lorber, T.3
  • 39
    • 44449108782 scopus 로고    scopus 로고
    • Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity
    • Hara M, Nakanishi H, Tsujimura K et al. Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity. Cancer Sci. 99(7), 1471-1478 (2008
    • (2008) Cancer Sci , vol.99 , Issue.7 , pp. 1471-1478
    • Hara, M.1    Nakanishi, H.2    Tsujimura, K.3
  • 40
    • 77957267869 scopus 로고    scopus 로고
    • Egfr-blockade by antibody cetuximab inhibits the growth of human gastric cancer xenograft in nude mice and its possible mechanism
    • Zhang J, Ji J, Yuan F et al. EGFR-blockade by antibody Cetuximab inhibits the growth of human gastric cancer xenograft in nude mice and its possible mechanism. Zhonghua Zhong Liu Za Zhi. 31(2), 85-89 (2000
    • (2000) Zhonghua Zhong Liu Za Zhi , vol.31 , Issue.2 , pp. 85-89
    • Zhang, J.1    Ji, J.2    Yuan, F.3
  • 41
    • 84865409125 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype
    • Hotz B, Keilholz U, Fusi A, Buhr HJ, Hotz HG. In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype. Gastric Cancer. 15(3), 252-64 (2012
    • (2012) Gastric Cancer , vol.15 , Issue.3 , pp. 252-264
    • Hotz, B.1    Keilholz, U.2    Fusi, A.3    Buhr, H.J.4    Hotz, H.G.5
  • 42
    • 77951739494 scopus 로고    scopus 로고
    • Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines
    • Luo HY, Wei W, Shi YX et al. Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines. Oncol. Rep. 23(6), 1735-1745 (2010
    • (2010) Oncol. Rep , vol.23 , Issue.6 , pp. 1735-1745
    • Luo, H.Y.1    Wei, W.2    Shi, Y.X.3
  • 43
    • 84863389751 scopus 로고    scopus 로고
    • Antitumor effect of cetuximab in combination with S-1 in EGFR-Amplified gastric cancer cells
    • Fukuda K, Saikawa Y, Takahashi M et al. Antitumor effect of cetuximab in combination with S-1 in EGFR-Amplified gastric cancer cells. Int. J. Oncol. 40(4), 975-982 (2012
    • (2012) Int. J. Oncol , vol.40 , Issue.4 , pp. 975-982
    • Fukuda, K.1    Saikawa, Y.2    Takahashi, M.3
  • 44
    • 83055161841 scopus 로고    scopus 로고
    • Antitumour activity of S-1 in combination with cetuximab on human gastric cancer cell lines in vivo
    • Kobunai T, Watanabe T, Fukusato T. Antitumour activity of S-1 in combination with cetuximab on human gastric cancer cell lines in vivo. Anticancer Res. 31(11), 3691-3696 (2011
    • (2011) Anticancer Res , vol.31 , Issue.11 , pp. 3691-3696
    • Kobunai, T.1    Watanabe, T.2    Fukusato, T.3
  • 45
    • 79960972076 scopus 로고    scopus 로고
    • Pertuzumab in combination with trastuzumab shows significantly enhanced antitumor activity in HER2-positive human gastric cancer xenograft models
    • Yamashita-Kashima Y, Iijima S, Yorozu K et al. Pertuzumab in combination with trastuzumab shows significantly enhanced antitumor activity in HER2-positive human gastric cancer xenograft models. Clin. Cancer Res. 17(15), 5060-5070 (2011
    • (2011) Clin. Cancer Res , vol.17 , Issue.15 , pp. 5060-5070
    • Yamashita-Kashima, Y.1    Iijima, S.2    Yorozu, K.3
  • 46
    • 84885953030 scopus 로고    scopus 로고
    • Lapatinib acts on gastric cancer through both antiproliferative function and augmentation of trastuzumab-mediated antibody-dependent cellular cytotoxicity
    • Epub ahead of print
    • Shiraishi K, Mimura K, Izawa S et al.; Lapatinib acts on gastric cancer through both antiproliferative function and augmentation of trastuzumab-mediated antibody-dependent cellular cytotoxicity. Gastric Cancer. (2012) (Epub ahead of print
    • (2012) Gastric Cancer
    • Shiraishi, K.1    Mimura, K.2    Izawa, S.3
  • 47
    • 77649162889 scopus 로고    scopus 로고
    • Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-Amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo
    • Wainberg ZA, Anghel A, Desai AJ et al. Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-Amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. Clin. Cancer Res. 16(5), 1509-1519 (2010
    • (2010) Clin. Cancer Res , vol.16 , Issue.5 , pp. 1509-1519
    • Wainberg, Z.A.1    Anghel, A.2    Desai, A.J.3
  • 48
    • 72449149848 scopus 로고    scopus 로고
    • The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38
    • LaBonte MJ, Manegold PC, Wilson PM et al. The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38. Int. J. Cancer. 125(12), 2957-2969 (2009
    • (2009) Int. J. Cancer , vol.125 , Issue.12 , pp. 2957-2969
    • LaBonte, M.J.1    Manegold, P.C.2    Wilson, P.M.3
  • 49
    • 84877646454 scopus 로고    scopus 로고
    • Y-box binding protein-1 contributes to both HER2/ErbB2 expression and lapatinib sensitivity in human gastric cancer cells
    • Shibata T, Kan H, Murakami Y et al. Y-box binding protein-1 contributes to both HER2/ErbB2 expression and lapatinib sensitivity in human gastric cancer cells. Mol. Cancer Ther. 12(5), 737-746 (2013
    • (2013) Mol. Cancer Ther , vol.12 , Issue.5 , pp. 737-746
    • Shibata, T.1    Kan, H.2    Murakami, Y.3
  • 50
    • 33845240595 scopus 로고    scopus 로고
    • Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis
    • Yokoyama H, Ikehara Y, Kodera Y et al. Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis. Br. J. Cancer 95(11), 1504-1513 (2006
    • (2006) Br. J. Cancer , vol.95 , Issue.11 , pp. 1504-1513
    • Yokoyama, H.1    Ikehara, Y.2    Kodera, Y.3
  • 51
    • 20144375830 scopus 로고    scopus 로고
    • Gefitinib (Iressa, ZD1839) inhibits SN38-Triggered EGF signals and IL-8 production in gastric cancer cells
    • Kishida O, Miyazaki Y, Murayama Y et al. Gefitinib (Iressa, ZD1839) inhibits SN38-Triggered EGF signals and IL-8 production in gastric cancer cells. Cancer Chemother. Pharmacol. 55(4), 393-403 (2005
    • (2005) Cancer Chemother. Pharmacol , vol.55 , Issue.4 , pp. 393-403
    • Kishida, O.1    Miyazaki, Y.2    Murayama, Y.3
  • 52
    • 80054861063 scopus 로고    scopus 로고
    • Darpp-32 increases interactions between epidermal growth factor receptor and erbb3 to promote tumor resistance to gefitinib
    • Zhu S, Belkhiri A, El-Rifai W. DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib. Gastroenterology 141(5), 1738-1748 (2011
    • (2011) Gastroenterology , vol.141 , Issue.5 , pp. 1738-1748
    • Zhu, S.1    Belkhiri, A.2    El-Rifai, W.3
  • 53
    • 0027787818 scopus 로고
    • Antiproliferative effect of tyrosine kinase inhibitors in epidermal growth factor-stimulated growth of human gastric cancer cells
    • Piontek M, Hengels KJ, Porschen R, Strohmeyer G. Antiproliferative effect of tyrosine kinase inhibitors in epidermal growth factor-stimulated growth of human gastric cancer cells. Anticancer Res. 13(6A), 2119-2123 (1993
    • (1993) Anticancer Res , vol.13 , Issue.6 A , pp. 2119-2123
    • Piontek, M.1    Hengels, K.J.2    Porschen, R.3    Strohmeyer, G.4
  • 54
    • 84863169318 scopus 로고    scopus 로고
    • Evaluation of the antitumor effects and mechanisms of pf00299804, a pan-her inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer
    • Nam HJ, Ching KA, Kan J et al. Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer. Mol. Cancer Ther. 11(2), 439-451 (2012
    • (2012) Mol. Cancer Ther , vol.11 , Issue.2 , pp. 439-451
    • Nam, H.J.1    Ching, K.A.2    Kan, J.3
  • 55
    • 79957834501 scopus 로고    scopus 로고
    • A multicenter phase II trial of single-Agent cetuximab in advanced esophageal and gastric adenocarcinoma
    • Chan JA, Blaszkowsky LS, Enzinger PC et al. A multicenter phase II trial of single-Agent cetuximab in advanced esophageal and gastric adenocarcinoma. Ann. Oncol. 22(6), 1367-1373 (2011
    • (2011) Ann. Oncol , vol.22 , Issue.6 , pp. 1367-1373
    • Chan, J.A.1    Blaszkowsky, L.S.2    Enzinger, P.C.3
  • 56
    • 76349109904 scopus 로고    scopus 로고
    • Cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric cancer: A phase II study of the arbeitsgemeinschaft internistische onkologie (AIO
    • Lordick F, Luber B, Lorenzen S et al. Cetuximab plus oxaliplatin/ leucovorin/5-fluorouracil in first-line metastatic gastric cancer: A phase II study of the arbeitsgemeinschaft internistische onkologie (AIO). Br. J. Cancer. 102(3), 500-505 (2010
    • (2010) Br. J. Cancer , vol.102 , Issue.3 , pp. 500-505
    • Lordick, F.1    Luber, B.2    Lorenzen, S.3
  • 57
    • 80052439302 scopus 로고    scopus 로고
    • Phase II trial of modified FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction
    • Wainberg ZA, Lin LS, DiCarlo B et al. Phase II trial of modified FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction. Br. J. Cancer. 105(6), 760-765 (2011
    • (2011) Br. J. Cancer , vol.105 , Issue.6 , pp. 760-765
    • Wainberg, Z.A.1    Lin, L.S.2    DiCarlo, B.3
  • 58
    • 80054057131 scopus 로고    scopus 로고
    • Southwest Oncology Group study S0413: A phase II trial of lapatinib (GW572016) as first-line therapy in patients with advanced or metastatic gastric cancer
    • Iqbal S, Goldman B, Fenoglio-Preiser CM et al. Southwest Oncology Group study S0413: A phase II trial of lapatinib (GW572016) as first-line therapy in patients with advanced or metastatic gastric cancer. Ann. Oncol. 22(12), 2610-2615 (2011
    • (2011) Ann. Oncol , vol.22 , Issue.12 , pp. 2610-2615
    • Iqbal, S.1    Goldman, B.2    Fenoglio-Preiser, C.M.3
  • 59
    • 77951885560 scopus 로고    scopus 로고
    • A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer
    • Bamias A, Karina M, Papakostas P et al. A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer. Cancer Chemother. Pharmacol. 65(6), 1009-1021 (2010
    • (2010) Cancer Chemother. Pharmacol , vol.65 , Issue.6 , pp. 1009-1021
    • Bamias, A.1    Karina, M.2    Papakostas, P.3
  • 60
    • 84876992498 scopus 로고    scopus 로고
    • Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): A randomised, open-label phase 3 trial
    • Waddell T, Chau I, Cunningham D et al. Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): A randomised, open-label phase 3 trial. Lancet Oncol. 14(6), 481-489 (2013
    • (2013) Lancet Oncol , vol.14 , Issue.6 , pp. 481-489
    • Waddell, T.1    Chau, I.2    Cunningham, D.3
  • 61
    • 80053653017 scopus 로고    scopus 로고
    • Mechanism of EGFR-related cancer drug resistance
    • Wei X. Mechanism of EGFR-related cancer drug resistance. Anticancer Drugs 22(10), 963-970 (2011
    • (2011) Anticancer Drugs , vol.22 , Issue.10 , pp. 963-970
    • Wei, X.1


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