Antisense epidermal growth factor receptor delivered by adenoviral vector blocks tumor growth in human gastric cancer

Cancer Gene Therapy

Volumn 6, Issue 5, 1999, Pages 423-427

  Hirao, Tomoko ^a   Sawada, Hidetomo ^a   Koyama, Fumikazu ^a   Watanabe, Akihiko ^a   Yamada, Yukishige ^a   Sakaguchi, Teruyuki ^a   Tatsumi, Mitsutoshi ^a   Fujimoto, Heisuke ^a   Emoto, Kouji ^a   Narikiyo, Michihiro ^a   Oridate, Nobuhiko ^b   Nakano, Hiroshige ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Adenoviral vector; Antisense; Epidermal growth factor receptor; Gastric cancer

Indexed keywords

COMPLEMENTARY RNA; EPIDERMAL GROWTH FACTOR RECEPTOR;

ADENOVIRUS; ANIMAL; ARTICLE; CELL CULTURE; CELL DIVISION; GENE VECTOR; GENETICS; HUMAN; MOUSE; PATHOLOGY; STOMACH TUMOR;

ADENOVIRIDAE; ANIMALS; CELL DIVISION; GENETIC VECTORS; HUMANS; MICE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, ANTISENSE; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0033194483     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700058     Document Type: Article

References (16)

1. Patino J. The current management of gastric cancer. Adv Surg. 1994;27:1-19.
2. Wanebo H, Kennedy B, Chmiel J, Steele G, Winchester D, Osteen R. Cancer of the stomach: a patient care study by the American College of Surgeons. Ann Surg. 1993;218:583-592.
3. Rusch V, Mendelsohn J, Dmitrovsky E. The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors. Cytokine Growth Factor Rev. 1996;7:133-141.
4. Hirono Y, Tsugawa K, Fushida S, et al. Amplification of epidermal growth factor receptor gene and its relationship to survival in human gastric cancer. Oncology. 1995;52:182-188.
5. Moroni M, Willingham M, Beguinot L. EGF-R antisense RNA blocks expression of the epidermal growth factor receptor and suppresses the transforming phenotype of a human carcinoma cell line. J Biol Chem. 1992;267:2714-2722.
6. Baselga J, Norton L, Masui H, et al. Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J Natl Cancer Inst. 1993;85:1327-1333.
7. Divgi C, Welt S, Kris M, et al. Phase I and imaging trial of Indium 111-labeled anti-epidermal growth factor receptor monoclonal antibody 225 in patients with squamous cell lung carcinoma. J Natl Cancer Inst. 1991;83:97-104.
8. Grandis J, Chakraborty A, Melhem M, Zeng Q, Tweardy D. Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. Oncogene. 1997;15:409-416.
9. Graham FL, Prevec L. Methods for construction of adenovirus vectors. Mol Biotechnol. 1995;3:207-220.
10. Kanegae Y, Makikura M, Saito I. A simple and efficient method for purification of infectious recombinant adenovirus. Jpn J Med Sci Biol. 1994;47:157-166.
11. Sawada H, Hirao T, Watanabe A, et al. Efficiency of gene transfer into human gastric carcinoma cells using adenovirus vector, progress in gastric cancer research 1997: Proceedings of The 2nd International Gastric Congress, Bologna Italy: Monduzzi Editore; 1997: 677-681.
12. Sawada H, Nawa A, Mora E, Cavanaugh P, Nicolson G. Differential motility stimulation but not growth stimulation or adhesion of metastatic human colorectal carcinoma cells by target organ-derived liver sinusoidal endothelial cells. Clin Exp Metastasis. 1996;14:308-314.
13. Wang S, Lee RJ, Cauchon G, Gorenstein DG, Low PS. Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc Natl Acad Sci USA. 1995;92:3318-3322.
14. Rubenstein M, Mirochnik Y, Chou P, Guinan P. Antisense oligonucleotide intralesional therapy for human PC-3 prostate tumors carried in athymic nude mice. J Surg Oncol. 1996;62:194-200.
15. Brody S, Crystal R. Adenovirus-mediated in vivo gene therapy. Ann N Y Acad Sci. 1993;716:90-103.
16. Lee C, Wu S, Gabrlovich D, et al. Antitumor effects of an adenovirus expressing antisense insulin-like growth factor I receptor on human lung cancer cell lines. Cancer Res. 1996; 56:3038-3041.