-
2
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of her2-positive advanced gastric or gastro-oesophageal junction cancer (toga): A phase 3, open-label, randomised controlled trial
-
Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, Aprile G, Kulikov E, Hil J, Lehle M, Rüschoff J, Kang YK: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial. Lancet 2010; 376: 687-697
-
(2010)
Lancet
, vol.376
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
Feyereislova, A.3
Chung, H.C.4
Shen, L.5
Sawaki, A.6
Lordick, F.7
Ohtsu, A.8
Omuro, Y.9
Satoh, T.10
Aprile, G.11
Kulikov, E.12
Hil, J.13
Lehle, M.14
Rüschoff, J.15
Kang, Y.K.16
-
3
-
-
50849123421
-
Her2 in gastric cancer: A new prognostic factor and a novel therapeutic target
-
Gravalos C, Jimeno A: HER2 in gastric cancer: A new prognostic factor and a novel therapeutic target. Ann Oncol 2008; 19: 1523-1529
-
(2008)
Ann Oncol
, vol.19
, pp. 1523-1529
-
-
Gravalos, C.1
Jimeno, A.2
-
4
-
-
44249092320
-
Assessment of a HER2 scoring system for gastric cancer: Results from a validation study
-
Hofmann M, Stoss O, Shi D, Büttner R, Van de Vijver M, Kim W, Ochiai A, Rüschoff J, Henkel T: Assessment of a HER2 scoring system for gastric cancer: Results from a validation study. Histopathology 2008; 52: 797-805
-
(2008)
Histopathology
, vol.52
, pp. 797-805
-
-
Hofmann, M.1
Stoss, O.2
Shi, D.3
Büttner, R.4
Van De Vijver, M.5
Kim, W.6
Ochiai, A.7
Rüschoff, J.8
Henkel, T.9
-
5
-
-
84865429022
-
Efficacy of trastuzumab in japanese patients with her2-positive advanced gastric or gastroesophageal junction cancer: A subgroup analysis of the trastuzumab for gastric cancer (toga) study
-
Sawaki A, Ohashi Y, Omuro Y, Satoh T, Hamamoto Y, Boku N, Miyata Y, Takiuchi H, Yamaguchi K, Sasaki Y, Nishina T, Satoh A, Baba E, Tamura T, Abe T, Hatake K, Ohtsu A: Efficacy of trastuzumab in Japanese patients with HER2-positive advanced gastric or gastroesophageal junction cancer: A subgroup analysis of the Trastuzumab for Gastric Cancer (ToGA) study. Gastric Cancer 2012; 15: 313-322
-
(2012)
Gastric Cancer
, vol.15
, pp. 313-322
-
-
Sawaki, A.1
Ohashi, Y.2
Omuro, Y.3
Satoh, T.4
Hamamoto, Y.5
Boku, N.6
Miyata, Y.7
Takiuchi, H.8
Yamaguchi, K.9
Sasaki, Y.10
Nishina, T.11
Satoh, A.12
Baba, E.13
Tamura, T.14
Abe, T.15
Hatake, K.16
Ohtsu, A.17
-
6
-
-
20044372721
-
Amplification of her-2 in gastric carcinoma: Association with topoisomerase iiα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab
-
Tanner M, Hollmén M, Junttila TT, Kapanen AI, Tommola S, Soini Y, Helin H, Salo J, Joensuu H, Sihvo E, Elenius K, Isola J: Amplification of HER-2 in gastric carcinoma: Association with Topoisomerase IIα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann Oncol 2005; 16: 273-278
-
(2005)
Ann Oncol
, vol.16
, pp. 273-278
-
-
Tanner, M.1
Hollmén, M.2
Junttila, T.T.3
Kapanen, A.I.4
Tommola, S.5
Soini, Y.6
Helin, H.7
Salo, J.8
Joensuu, H.9
Sihvo, E.10
Elenius, K.11
Isola, J.12
-
7
-
-
35448969823
-
Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer
-
Pályi-Krekk Z, Barok M, Isola J, Tammi M, Szöllosi J, Nagy P: Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer. Eur J Cancer 2007; 43: 2423-2433
-
(2007)
Eur J Cancer
, vol.43
, pp. 2423-2433
-
-
Pályi-Krekk, Z.1
Barok, M.2
Isola, J.3
Tammi, M.4
Szöllosi, J.5
Nagy, P.6
-
8
-
-
0036187710
-
NH 2-Terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer
-
Molina MA, Sáez R, Ramsey EE, Garcia-Barchino MJ, Rojo F, Evans AJ, Albanell J, Keenan EJ, Lluch A, García-Conde J, Baselga J, Clinton GM: NH 2-Terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. Clin Cancer Res 2002; 8: 347-353
-
(2002)
Clin Cancer Res
, vol.8
, pp. 347-353
-
-
Molina, M.A.1
Sáez, R.2
Ramsey, E.E.3
Garcia-Barchino, M.J.4
Rojo, F.5
Evans, A.J.6
Albanell, J.7
Keenan, E.J.8
Lluch, A.9
García-Conde, J.10
Baselga, J.11
Clinton, G.M.12
-
9
-
-
34247588567
-
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
-
Scaltriti M, Rojo F, Ocaña A, Anido J, Guzman M, Cortes J, Di Cosimo S, Matias-Guiu X, Ramon y Cajal S, Arribas J, Baselga J: Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst 2007; 99: 628-638
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 628-638
-
-
Scaltriti, M.1
Rojo, F.2
Ocaña, A.3
Anido, J.4
Guzman, M.5
Cortes, J.6
Di Cosimo, S.7
Matias-Guiu, X.8
Ramon, Y.9
Cajal, S.10
Arribas, J.11
Baselga, J.12
-
10
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J, Cantley LC: The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006; 7: 606-619
-
(2006)
Nat Rev Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
11
-
-
77950617839
-
Clinical significance of pten and p-Akt co-expression in her2-positive metastatic breast cancer patients treated with trastuzumab-based therapies
-
Fabi A, Metro G, Di Benedetto A, Nisticò C, Vici P, Melucci E, Antoniani B, Perracchio L, Sperduti I, Milella M, Cognetti F, Mottolese M: Clinical significance of PTEN and p-Akt co-expression in HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies. Oncology 2010; 78: 141-149
-
(2010)
Oncology
, vol.78
, pp. 141-149
-
-
Fabi, A.1
Metro, G.2
Di Benedetto, A.3
Nisticò, C.4
Vici, P.5
Melucci, E.6
Antoniani, B.7
Perracchio, L.8
Sperduti, I.9
Milella, M.10
Cognetti, F.11
Mottolese, M.12
-
12
-
-
77951884331
-
Association between gain-of-function mutations in pik3ca and resistance to her2-Targeted agents in her2-Amplified breast cancer cell lines
-
Kataoka Y, Mukohara T, Shimada H, Saijo N, Hirai M, Minami H: Association between gain-of-function mutations in PIK3CA and resistance to HER2-Targeted agents in HER2-Amplified breast cancer cell lines. Ann Oncol 2010; 21: 255-262
-
(2010)
Ann Oncol
, vol.21
, pp. 255-262
-
-
Kataoka, Y.1
Mukohara, T.2
Shimada, H.3
Saijo, N.4
Hirai, M.5
Minami, H.6
-
13
-
-
34547574720
-
A new mutational AKTivation in the PI3K pathway
-
Brugge J, Hung MC, Mills GB: A new mutational AKTivation in the PI3K pathway. Cancer Cell 2007; 12: 104-107
-
(2007)
Cancer Cell
, vol.12
, pp. 104-107
-
-
Brugge, J.1
Hung, M.C.2
Mills, G.B.3
-
14
-
-
77956112407
-
Approaches and limitations of phosphatidylinositol-3-kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy
-
Coughlin CM, Johnston DS, Strahs A, Burczynski ME, Bacus S, Hill J, Feingold JM, Zacharchuk C, Berkenblit A: Approaches and limitations of phosphatidylinositol-3-kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy. Breast Cancer Res Treat 2010; 124: 1-11
-
(2010)
Breast Cancer Res Treat
, vol.124
, pp. 1-11
-
-
Coughlin, C.M.1
Johnston, D.S.2
Strahs, A.3
Burczynski, M.E.4
Bacus, S.5
Hill, J.6
Feingold, J.M.7
Zacharchuk, C.8
Berkenblit, A.9
-
15
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M, Beijersbergen RL, Mills GB, van de Vijver MJ, Bernards R: A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007; 12: 395-402
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
Madiredjo, M.4
Hijmans, E.M.5
Beelen, K.6
Linn, S.C.7
Gonzalez-Angulo, A.M.8
Stemke-Hale, K.9
Hauptmann, M.10
Beijersbergen, R.L.11
Mills, G.B.12
Van De Vijver, M.J.13
Bernards, R.14
-
16
-
-
28244432561
-
Insulin-like growth factor-I receptor/ human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
-
Nahta R, Yuan LX, Zhang B, Kobayashi R, Esteva FJ: Insulin-like growth factor-I receptor/ human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 2005; 65: 11118-11128
-
(2005)
Cancer Res
, vol.65
, pp. 11118-11128
-
-
Nahta, R.1
Yuan, L.X.2
Zhang, B.3
Kobayashi, R.4
Esteva, F.J.5
-
17
-
-
42649130333
-
Her2 cross talk and therapeutic resistance in breast cancer
-
Bender LM, Nahta R: Her2 cross talk and therapeutic resistance in breast cancer. Front Biosci 2008; 13: 3906-3912
-
(2008)
Front Biosci
, vol.13
, pp. 3906-3912
-
-
Bender, L.M.1
Nahta, R.2
-
18
-
-
40449113978
-
Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells
-
Shattuck DL, Miller JK, Carraway KL 3rd, Sweeney C: Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells. Cancer Res 2008; 68: 1471-1477
-
(2008)
Cancer Res
, vol.68
, pp. 1471-1477
-
-
Shattuck, D.L.1
Miller, J.K.2
Carraway IiI, K.L.3
Sweeney, C.4
-
19
-
-
84867817838
-
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
-
Liao X, Lochhead P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M, Imamura Y, Qian ZR, Baba Y, Shima K, Sun R, Nosho K, Meyerhardt JA, Giovannucci E, Fuchs CS, Chan AT, Ogino S: Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 2012; 367: 1596-1606
-
(2012)
N Engl J Med
, vol.367
, pp. 1596-1606
-
-
Liao, X.1
Lochhead, P.2
Nishihara, R.3
Morikawa, T.4
Kuchiba, A.5
Yamauchi, M.6
Imamura, Y.7
Qian, Z.R.8
Baba, Y.9
Shima, K.10
Sun, R.11
Nosho, K.12
Meyerhardt, J.A.13
Giovannucci, E.14
Fuchs, C.S.15
Chan, A.T.16
Ogino, S.17
-
20
-
-
79952851688
-
Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers
-
Baba Y, Nosho K, Shima K, Hayashi M, Meyerhardt JA, Chan AT, Giovannucci E, Fuchs CS, Ogino S: Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers. Cancer 2011; 117: 1399-1408
-
(2011)
Cancer
, vol.117
, pp. 1399-1408
-
-
Baba, Y.1
Nosho, K.2
Shima, K.3
Hayashi, M.4
Meyerhardt, J.A.5
Chan, A.T.6
Giovannucci, E.7
Fuchs, C.S.8
Ogino, S.9
-
21
-
-
44449133319
-
PIK3CA mutation in colorectal cancer: Relationship with genetic and epigenetic alterations
-
Nosho K, Kawasaki T, Ohnishi M, Suemoto Y, Kirkner GJ, Zepf D, Yan L, Longtine JA, Fuchs CS, Ogino S: PIK3CA mutation in colorectal cancer: Relationship with genetic and epigenetic alterations. Neoplasia 2008; 10: 534-541
-
(2008)
Neoplasia
, vol.10
, pp. 534-541
-
-
Nosho, K.1
Kawasaki, T.2
Ohnishi, M.3
Suemoto, Y.4
Kirkner, G.J.5
Zepf, D.6
Yan, L.7
Longtine, J.A.8
Fuchs, C.S.9
Ogino, S.10
-
22
-
-
79960231716
-
Pyrosequencingbased methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours
-
Weidlich S, Walsh K, Crowther D, Burczynski ME, Feuerstein G, Carey FA, Steele RJ, Wolf CR, Miele G, Smith G: Pyrosequencingbased methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours. Br J Cancer 2011; 105: 246-254
-
(2011)
Br J Cancer
, vol.105
, pp. 246-254
-
-
Weidlich, S.1
Walsh, K.2
Crowther, D.3
Burczynski, M.E.4
Feuerstein, G.5
Carey, F.A.6
Steele, R.J.7
Wolf, C.R.8
Miele, G.9
Smith, G.10
-
23
-
-
84873885753
-
Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer
-
Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M, Mikami M, Matsuno T, Hasegawa T, Hirata K, Imai K, Shinomura Y: Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer. World J Gastroenterol 2012; 18: 6577-6586
-
(2012)
World J Gastroenterol
, vol.18
, pp. 6577-6586
-
-
Sukawa, Y.1
Yamamoto, H.2
Nosho, K.3
Kunimoto, H.4
Suzuki, H.5
Adachi, Y.6
Nakazawa, M.7
Nobuoka, T.8
Kawayama, M.9
Mikami, M.10
Matsuno, T.11
Hasegawa, T.12
Hirata, K.13
Imai, K.14
Shinomura, Y.15
-
24
-
-
77950819136
-
The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type
-
Barbi S, Cataldo I, De Manzoni G, Bersani S, Lamba S, Mattuzzi S, Bardelli A, Scarpa A: The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type. J Exp Clin Cancer Res 2010; 29: 32
-
(2010)
J Exp Clin Cancer Res
, vol.29
, pp. 32
-
-
Barbi, S.1
Cataldo, I.2
De Manzoni, G.3
Bersani, S.4
Lamba, S.5
Mattuzzi, S.6
Bardelli, A.7
Scarpa, A.8
-
25
-
-
79952713255
-
A unique spectrum of somatic PIK3CA (p110α) mutations within primary endometrial carcinomas
-
Rudd ML, Price JC, Fogoros S, Godwin AK, Sgroi DC, Merino MJ, Bell DW: A unique spectrum of somatic PIK3CA (p110α) mutations within primary endometrial carcinomas. Clin Cancer Res 2011; 17: 1331-1340
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1331-1340
-
-
Rudd, M.L.1
Price, J.C.2
Fogoros, S.3
Godwin, A.K.4
Sgroi, D.C.5
Merino, M.J.6
Bell, D.W.7
-
26
-
-
54249159640
-
PIK3CA cooperates with other phosphatidylinositol 3 ′ kinase pathway mutations to effect oncogenic transformation
-
Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, Mc-Cormick F: PIK3CA cooperates with other phosphatidylinositol 3 ′-kinase pathway mutations to effect oncogenic transformation. Cancer Res 2008; 68: 8127-8136
-
(2008)
Cancer Res
, vol.68
, pp. 8127-8136
-
-
Oda, K.1
Okada, J.2
Timmerman, L.3
Rodriguez-Viciana, P.4
Stokoe, D.5
Shoji, K.6
Taketani, Y.7
Kuramoto, H.8
Knight, Z.A.9
Shokat, K.M.10
Mc-Cormick, F.11
-
27
-
-
67649382929
-
Akt-independent signaling downstream of oncogenic pik3ca mutations in human cancer
-
Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA: AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 2009; 16: 21-32
-
(2009)
Cancer Cell
, vol.16
, pp. 21-32
-
-
Vasudevan, K.M.1
Barbie, D.A.2
Davies, M.A.3
Rabinovsky, R.4
McNear, C.J.5
Kim, J.J.6
Hennessy, B.T.7
Tseng, H.8
Pochanard, P.9
Kim, S.Y.10
Dunn, I.F.11
Schinzel, A.C.12
Sandy, P.13
Hoersch, S.14
Sheng, Q.15
Gupta, P.B.16
Boehm, J.S.17
Reiling, J.H.18
Silver, S.19
Lu, Y.20
Stemke-Hale, K.21
Dutta, B.22
Joy, C.23
Sahin, A.A.24
Gonzalez-Angulo, A.M.25
Lluch, A.26
Rameh, L.E.27
Jacks, T.28
Root, D.E.29
Lander, E.S.30
Mills, G.B.31
Hahn, W.C.32
Sellers, W.R.33
Garraway, L.A.34
more..
-
28
-
-
84864540451
-
PTEN deletion is rare but often homogeneous in gastric cancer
-
Mina S, Bohn BA, Simon R, Krohn A, Reeh M, Arnold D, Bokemeyer C, Sauter G, Izbicki JR, Marx A, Stahl PR: PTEN deletion is rare but often homogeneous in gastric cancer. J Clin Pathol 2012; 65: 693-698
-
(2012)
J Clin Pathol
, vol.65
, pp. 693-698
-
-
Mina, S.1
Bohn, B.A.2
Simon, R.3
Krohn, A.4
Reeh, M.5
Arnold, D.6
Bokemeyer, C.7
Sauter, G.8
Izbicki, J.R.9
Marx, A.10
Stahl, P.R.11
-
29
-
-
84876312892
-
MiR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN
-
Yang SM, Huang C, Li XF, Yu MZ, He Y, Li J: MiR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN. Toxicology 2013; 306: 162-168
-
(2013)
Toxicology
, vol.306
, pp. 162-168
-
-
Yang, S.M.1
Huang, C.2
Li, X.F.3
Yu, M.Z.4
He, Y.5
Li, J.6
-
30
-
-
79151478956
-
Role of DNA methylation in the development of diffuse-Type gastric cancer
-
Yamamoto E, Suzuki H, Takamaru H, Yamamoto H, Toyota M, Shinomura Y: Role of DNA methylation in the development of diffuse-Type gastric cancer. Digestion 2011; 83: 241-249
-
(2011)
Digestion
, vol.83
, pp. 241-249
-
-
Yamamoto, E.1
Suzuki, H.2
Takamaru, H.3
Yamamoto, H.4
Toyota, M.5
Shinomura, Y.6
|