Genetic risk score does not predict the outcome of obesity surgery

Obesity Surgery

Volumn 24, Issue 1, 2014, Pages 128-133

  Kakela P ^a   Jaaskelainen T ^b   Torpstrom J ^a   Ilves, I ^a   Venesmaa, S ^a   Paakkonen M ^a   Gylling, H ^b,c   Paajanen, H ^a   Uusitupa, M ^a,b   Pihlajamaki J ^a,b  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Genetics; Laparoscopic Roux en Y gastric bypass; Obesity; Weight loss

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BARIATRIC SURGERY; BODY MASS; CHOLESTEROL BLOOD LEVEL; DIET RESTRICTION; FEMALE; FOLLOW UP; GENE FREQUENCY; GENETIC RISK; GENETIC RISK SCORE; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIVER BIOPSY; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NONALCOHOLIC FATTY LIVER; OBESITY; OUTCOME ASSESSMENT; PREDICTION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; ROUX EN Y GASTRIC BYPASS; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEVE GASTRECTOMY; STOMACH BYPASS; TRIACYLGLYCEROL BLOOD LEVEL; WAIST HIP RATIO; WEIGHT GAIN; WEIGHT REDUCTION;

ADULT; BARIATRIC SURGERY; FEMALE; GASTRECTOMY; GASTRIC BYPASS; HUMANS; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT; TREATMENT OUTCOME; WAIST-HIP RATIO; WEIGHT GAIN; WEIGHT LOSS;

EID: 84893049275     PISSN: 09608923     EISSN: 17080428     Source Type: Journal    
DOI: 10.1007/s11695-013-1080-2     Document Type: Article

References (33)

1. Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med. 2009;122:248-56.
2. Pories WJ, Swanson MS, MacDonald KG, et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann Surg. 1995;222(3):339-52.
3. Alger-Mayer S, Polimeni JM, Malone M. Preoperative weight loss as a predictor of long-term success following Roux-en-Y gastric bypass. Obes Surg. 2008;18(7):772-5.
4. Livhits M, Mercado C, Yermilov I, et al. Preoperative predictors of weight loss following bariatric surgery: systematic review. Obes Surg. 2012;22(1):70-89.
5. Kadeli DK, Sczepaniak JP, Kumar K et al. The effect of preoperative weight loss before gastric bypass: a systematic review. J Obes 2012; 2012. Epub 2012 June 7. ID: 867540, 7 pages
6. Alvarado R, Alami RS, Hsu G, et al. The impact of preoperative weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2005;15(9):1282-6.
7. Ma Y, Pagoto SL, Olendzki BC, et al. Predictors of weight status following laparoscopic gastric bypass. Obes Surg. 2006;16(9):1227-31.
8. Biertho L, Steffen R, Ricklin T, et al. Laparoscopic gastric bypass versus laparoscopic adjustable gastric banding. A comparative study of 1,200 cases. J Am Coll Surg. 2003;197(4):545-6.
9. Magro DO, Geloneze B, Delfini R, et al. Long-term weight regain after gastric bypass: a 5-year prospective study. Obes Surg. 2008;18(6):648-51.
10. Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with Body Mass Index and predisposes to childhood and adult obesity. Science. 2007;316:889-94.
11. Scuteri A, Sanna S, Chen WM, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007;3(7):e115.
12. Willer CJ, Speliotes EK, Loos RJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41:25-34.
13. Thorleifsson G, Walters GB, Gudbjartsson DF, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2009;41:18-24.
14. Loos RJ, Lindgren CM, Li S, et al. Common variant near MC4R are associated with Fat Mass, Weight and risk of obesity. Nat Genet. 2008;40:768-75.
15. Speliotes EK, Willer CJ, Berndt SI, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42:937-48.
16. Heid IM, Jackson AU, Randall JC, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010;42:949-60.
17. Sarzynski MA, Jacobson P, Rankinen T, et al. Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Int J Obes. 2011;35:676-83.
18. Pihlajamäki J, Kuulasmaa T, Kaminska D, et al. Serum interleukin 1 receptor antagonist as an independent marker of nonalcoholic steatohepatitis in humans. Int J Hepatol. 2012;3:663-70.
19. Conference NIH. Gastrointestinal surgery for severe obesity. Consensus Development Conference Panel. Ann Intern Med. 1991;115:956-61.
20. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2004;27:5-10.
21. Brunt EM, Janney CG, Di Bisceglie AM, et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94:2467-74.
22. Deitel M, Greenstein RJ. Recommendations for reporting weight loss. Obes Surg. 2003;13:159-60.
23. Li S, Zhao JH, Luan J, et al. Physical activity attenuates the genetic predisposition to obesity in 20 000 men and women from EPIC-Norfolk prospective population study. PLoS Med. 2010;7(8):e1000332.
24. Christou NV, Look D, Maclean LD. Weight gain after short- and long-limb gastric bypass in patients followed for longer than 10 years. Ann Surg. 2006;244(5):734-40.
25. Pajecki D, Dalcanalle L, de Oliveira CPMS, et al. Follow-up of Roux-en-Y gastric bypass patients at 5 or more years postoperatively. Obes Surg. 2007;17:601-7.
26. MacLean LD, Rhode BM, Nohr LW. Late outcome of isolated gastric bypass. Ann Surg. 1999;231:524-8.
27. Brolin RE, Kenler HA, Gorman JH, et al. Long-limb gastric bypass in the superobese. A prospective randomized study. Ann Surg. 1992;215:387-95.
28. Sjöström L, Narbro K, Sjöström CD, et al. Swedish Obese Subjects Study. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741-52.
29. Maggard MA, Shugarman LR, Suttorp M, et al. Meta-analysis: surgical treatment of obesity. Ann Intern Med. 2005;142(7):547-59.
30. Schauer PR, Burguera B, Ikramuddin S, et al. Effect of laparoscopic Roux-en-Y gastric bypass on type 2 diabetes mellitus. Ann Surg. 2003;238(4):467-85.
31. Chikunguwo S, Wolfe L, Dodson P, et al. Analysis of factors associated with durable remission of diabetes after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2009;6(3):254-9.
32. Mingrone G, Panunzi S, Gaetano A, et al. Bariatric Surgery versus conventional medical therapy for type 2 diabetes. N Engl J Med. 2012;366(17):1577-85.
33. Pories WJ, Dohm LG, Mansfield CJ. Beyond the BMI: The search for better guidelines for bariatric surgery. Obesity. 2010;18(5):865-71.