Schisandra chinensis prevents alcohol-induced fatty liver disease in rats

Journal of Medicinal Food

Volumn 17, Issue 1, 2014, Pages 103-110

  Park, Hyoung Joon ^a   Lee, Soo Jung ^a   Song, Yuno ^a   Jang, Sun Hee ^a   Ko, Yeoung Gyu ^b   Kang, Suk Nam ^a   Chung, Byung Yeoup ^c   Kim, Hong Duck ^d   Kim, Gon Sup ^a   Cho, Jae Hyeon ^a  

^a Gyeongsang National University   (South Korea)

^b National Institute of Animal Science   (South Korea)

^c Korea Atomic Energy Research Institute   (South Korea)

^d NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Accumulation; Alcoholic fatty liver; Lipid AMPK; PPARa; Schisandra chinensis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ANTHOCYANIN; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; FLAVONOID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIGNAN; LIVER PROTECTIVE AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHENOL DERIVATIVE; SCHISANDRA CHINENSIS EXTRACT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOLIC FATTY LIVER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CHEMICAL ANALYSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SYNTHESIS; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOBLOTTING; LIPID LIVER LEVEL; LIPID STORAGE; LIVER CELL; LIVER FATTY DEGENERATION; LIVER PROTECTION; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCHISANDRA CHINENSIS; SOLVENT EXTRACTION; TRIACYLGLYCEROL BLOOD LEVEL;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CHOLESTEROL; FATTY LIVER, ALCOHOLIC; HUMANS; LIVER; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PPAR ALPHA; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; SCHISANDRA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIGLYCERIDES;

EID: 84893037832     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2013.2849     Document Type: Article

References (33)

1. Sozio MS, Liangpunsakul S, Crabb D: The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis. Semin Liver Dis 2010;30:378-390.
2. You M, Crabb DW: Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver. Am J Physiol Gastrointest Liver Physiol 2004;287:1-6.
3. Tannapfel A, Denk H, Dienes HP, Langner C, Schirmacher P, Trauner M, Flott-Rahmel B: Histopathological diagnosis of nonalcoholic and alcoholic fatty liver disease. Virchows Arch 2011;458:511-523.
4. Stickel F, Seitz HK: Alcoholic steatohepatitis. Best Pract Res Clin Gastroenterol 2010;24:683-693.
5. Purohit V, Gao B, Song BJ: Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res 2009;33:191-205.
6. Anstee QM, Daly AK, Day CP: Genetics of alcoholic and nonalcoholic fatty liver disease. Semin Liver Dis 2011;31:128-146.
7. Tao R, Gong J, Luo X, Zang M, Guo W, Wen R, Luo Z: AMPK exerts dual regulatory effects on the PI3K pathway. J Mol Signal 2010;18:1-9.
8. Reddy JK, Rao MS: Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol 2006;290:852-858.
9. Rogers CQ, Ajmo JM, You M: Adiponectin and alcoholic fatty liver disease. IUBMB Life 2008;60:790-797.
10. Moriya T, Naito H, Ito Y, Nakajima T: "Hypothesis of seven balances": molecular mechanisms behind alcoholic liver diseases and association with PPARa. J Occup Health 2009;51: 391-403.
11. You M, Considine RV, Leone TC, Kelly DP, Crabb DW: Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 2005;42: 568-577.
12. Chang HF, Lin YH, Chu CC, Wu SJ, Tsai YH, Chao JC: Protective effects of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract on liver injury in rats. Am J Chin Med 2007;35: 995-1009.
13. Chien CF, Wu YT, Tsai TH: Biological analysis of herbal medicines used for the treatment of liver diseases. Biomed Chromatogr 2011;25:21-38.
14. Park HJ, Cho JY, Kim MK, Koh PO, Cho KW, Kim CH, Lee KS, Chung BY, Kim GS, Cho JH: Anti-obesity effect of Schisandra chinensis in 3T3-L1 cells and high fat diet-induced obese rats. Food Chem 2012;134:227-234.
15. Stacchiotti A, Li Volti G, Lavazza A, Rezzani R, Rodella LF: Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chloride. Food Chem Toxicol 2009;47: 2834-2840.
16. Wagner H, Bauer R, Peigen X, Jianming C, Nenninger A: Fructus Schisandrae (Wuweizi). In: Chinese Drug Monographs and Analysis. (Wühr E, ed.). Verlag für Ganzheitliche Medizin: Kotzting, 1996, pp. 467-489.
17. Wu X, Yu X, Jing H: Optimization of phenolic antioxidant extraction from Wuweizi (Schisandra chinensis) pulp using random- centroid optimization methodology. Int J Mol Sci 2011; 12:6255-6266.
18. Meda A, Lamien CE, Romito M, Millogo J, Nacoulma OG: Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chem 2005;91:571-577.
19. Song Y, Lee SJ, Park HJ, Jang SH, Chung BY, Song YM, Kim GS, Cho JH: Improvement effect of Schisandra chinensis on high-fat diet-induced fatty liver in rats. Korean J Vet Service 2013;36:45-52.
20. Na M, Hung TM, Oh WK, Min BS, Lee SH, Bae K: Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis. Phytother Res 2010;24: S225-S228.
21. Yan F, Zhang QY, Jiao L, Han T, Zhang H, Qin LP, Khalid R: Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats. Phytomedicine 2009;16:805-813.
22. Chiu PY, Leung HY, Poon MK, Ko KM: Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats. Biogerontology 2006;7:199-210.
23. Pan SY, Dong H, Zhao XY, Xiang CJ, Fang HY, Fong WF, Yu ZL, Ko KM: Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice. J Pharm Pharmacol 2008;60:399-403.
24. Burt AD, Mutton A, Day CP: Diagnosis and interpretation of steatosis and steatohepatitis. Semin Diagn Pathol 1998;15:246-258.
25. Rej R: Aspartate aminotransferase activity and isoenzymes proportions in human liver tissue. Clin Chem 1978;24:1971-1979.
26. Gross A, Ong TR, Grant R, Hoffmann T, Gregory DD, Sreerama L: Human aldehyde dehydrogenase-catalyzed oxidation of ethylene glycol ether aldehydes. Chem Biol Interact 2009;178:56-63.
27. Hennes HM, Smith DS, Schneider K, Hegenbarth MA, Duma MA, Jona JZ: Elevated liver transaminase levels in children with blunt abdominal trauma: a predictor of liver injury. Pediatrics 1990;86:87-90.
28. Goldberg DM, Watts C: Serum enzyme changes as evidence of liver reaction to oral alcohol. Gastroenterology 1965;49:256-261.
29. Kwon HJ, Kim YY, Choung SY: Amelioration effects of traditional Chinese medicine on alcohol-induced fatty liver. World J Gastroenterol 2005;11:5512-5516.
30. Qin Y, Tian YP: Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcoholinduced fatty liver diseases in mice. J Transl Med 2010;8: 120.
31. Wada S, Yamazaki T, Kawano Y, Miura S, Ezaki O: Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice. J Hepatol 2008;49:441-450.
32. Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL: Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest 1997;99:846-854.
33. Winder WW, Hardie DG: AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 1999;277:E1-E10.