Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of toll-like receptor (TLR)-induced cytokine production

Journal of Biological Chemistry

Volumn 289, Issue 4, 2014, Pages 2112-2126

  Niedzielska, Magdalena ^a   Bodendorfer, Barbara ^a   Münch, Sandra ^b   Eichner, Alexander ^c   Derigs, Marcus ^a   Da Costa, Olivia ^c   Schweizer, Astrid ^d   Neff, Frauke ^e   Nitschke, Lars ^d   Sparwasser, Tim ^c   Keyse, Stephen M ^b   Lang, Roland ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE PRODUCTION; CYTOKINE RESPONSE; IMMUNE RESPONSE; INNATE IMMUNE SYSTEMS; MAPK SIGNALING; MOUSE MODELS; NON-REDUNDANT; TOLL-LIKE RECEPTORS;

GENES; IMMUNE SYSTEM; PHOSPHATASES;

MAMMALS;

CD11B ANTIGEN; CD69 ANTIGEN; COLONY STIMULATING FACTOR 1; CXCL11 CHEMOKINE; DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE 16 A1 ISOFORM; DUAL SPECIFICITY PHOSPHATASE 16 B1 ISOFORM; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 23P19; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE 1; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; EMBRYO; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; FIBROBLAST CULTURE; GENE EXPRESSION REGULATION; GENE LOCUS; GENE TRAP; GENETIC PROCEDURES; GENOTYPE; HOMOZYGOTE; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE; MALE; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PERINATAL MORTALITY; PERINATAL PERIOD; PERINATAL SURVIVAL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION CHIMERA; SURVIVAL; UPREGULATION;

CYTOKINES/INTERFERON; DENDRITIC CELLS; DUAL SPECIFICITY PHOSPHATASE; ENDOTOXIN; GENE KNOCK-OUT; GENE TRAP; INNATE IMMUNITY; MACROPHAGES; MAP KINASES (MAPKS); PERINATAL LETHALITY;

ANIMALS; DUAL-SPECIFICITY PHOSPHATASES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; IMMUNITY, INNATE; INTERLEUKIN-10; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; TOLL-LIKE RECEPTORS;

EID: 84893035548     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.535245     Document Type: Article

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