AMPK-mediated downregulation of connexin43 and premature senescence of mesangial cells under high-glucose conditions

Experimental Gerontology

Volumn 51, Issue 1, 2014, Pages 71-81

  Guo, Ya Nan ^a   Wang, Jing Chao ^a,b   Cai, Guang Yan ^a   Hu, Xiao ^a   Cui, Shao Yuan ^a   Lv, Yang ^a   Yin, Zhong ^a   Fu, Bo ^a   Hong, Quan ^a   Chen, Xiang Mei ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

AMPK; Connexin43; Diabetic nephropathy; Mesangial cell senescence; MTOR

Indexed keywords

ADENOSINE KINASE; CONNEXIN 43; GLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; PROTEIN P21; PROTEIN P27; RAPAMYCIN;

ANIMAL CELL; ARTICLE; CELL AGING; CELL DENSITY; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MESANGIUM CELL; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SENESCENCE; SIGNAL TRANSDUCTION;

AMPK; CONNEXIN43; DIABETIC NEPHROPATHY; MESANGIAL CELL SENESCENCE; MTOR;

AMP-ACTIVATED PROTEIN KINASES; CELL AGING; CELLS, CULTURED; CONNEXIN 43; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DIABETIC NEPHROPATHIES; DOWN-REGULATION; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; KIDNEY GLOMERULUS; MESANGIAL CELLS; METFORMIN; SIGNAL TRANSDUCTION; SIROLIMUS; SWEETENING AGENTS; TOR SERINE-THREONINE KINASES;

EID: 84893031792     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2013.12.016     Document Type: Article

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