Elastin-based protein polymer nanoparticles carrying drug at both corona and core suppress tumor growth in vivo

Journal of Controlled Release

Volumn 171, Issue 3, 2013, Pages 330-338

  Shi, Pu ^a   Aluri, Suhaas ^a   Lin, Yi An ^b   Shah, Mihir ^a   Edman, Maria ^a   Dhandhukia, Jugal ^a   Cui, Honggang ^b   MacKay, J Andrew ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Johns Hopkins University   (United States)

Author keywords

Elastin like polypeptide; High specificity avidity; Nanoparticulate drug delivery; Protein polymer; Rapamycin encapsulation

Indexed keywords

BIOCHEMISTRY; DIAGNOSIS; DISEASES; DRUG PRODUCTS; ELASTIN; ENCAPSULATION; GLYCOPROTEINS; MOLECULES; NANOPARTICLES; POLYMERS; POLYPEPTIDES; SOLUBILITY; TOXICITY; TUMORS;

ELASTIN-LIKE POLYPEPTIDES; HIGH SPECIFICITY; NANO PARTICULATES; PROTEIN POLYMERS; RAPAMYCIN;

PROTEINS;

COPOLYMER; ELASTIN; ELASTIN LIKE POLYPEPTIDE; FK 506 BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; NANOCARRIER; NANOPARTICLE; POLYMER; POLYPEPTIDE; RAPAMYCIN; ROSE BENGAL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; CONTROLLED STUDY; COVALENT BOND; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG PENETRATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG TRANSPORT; ENCAPSULATION; HYPOTHESIS; IN VIVO STUDY; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; TUMOR GROWTH;

CMC; CMT; CRITICAL MICELLE CONCENTRATION; CRITICAL MICELLE TEMPERATURE; CRYO-TEM; CRYOGENIC-TRANSMISSION ELECTRON MICROSCOPY; DLS; DYNAMIC LIGHT SCATTERING; ELASTIN-LIKE POLYPEPTIDE; ELASTIN-LIKE POLYPEPTIDES; ELPS; FK506 BINDING PROTEIN 12; FKBP; HIGH-SPECIFICITY AVIDITY; INVERSE TRANSITION CYCLING; ITC; MAMMALIAN TARGET OF RAPAMYCIN; MTOR; NANOPARTICULATE DRUG DELIVERY; PROTEIN POLYMER; RAPA; RAPAMYCIN; RAPAMYCIN ENCAPSULATION; TEM; TRANSMISSION ELECTRON MICROSCOPY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG CARRIERS; ELASTIN; FEMALE; HUMANS; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; NANOPARTICLES; PEPTIDES; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84892923466     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.05.013     Document Type: Article

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