CYP2E1 hydroxylation of aniline involves negative cooperativity

Biochemical Pharmacology

Volumn 87, Issue 3, 2014, Pages 523-533

  Hartman, Jessica H ^a   Knott, Katie ^a,b   Miller, Grover P ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF CENTRAL ARKANSAS   (United States)

Author keywords

Aniline; Cooperativity; CYP2E1; Cytochrome P450; Metabolism

Indexed keywords

4 METHYLPYRAZOLE; ANILINE; CYTOCHROME P450 2A6; CYTOCHROME P450 2C9; CYTOCHROME P450 2E1;

ARTICLE; BINDING SITE; CHEMICAL REACTION KINETICS; CLEARANCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROXYLATION; IN VITRO STUDY; LIVER MICROSOME; MICHAELIS MENTEN KINETICS; NEGATIVE COOPERATIVITY; PHENOTYPE; PRIORITY JOURNAL;

ANILINE; COOPERATIVITY; CYP2E1; CYTOCHROME P450; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HPLC; METABOLISM;

ANILINE COMPOUNDS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP2E1; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXYLATION; MICROSOMES, LIVER; PYRAZOLES;

EID: 84892909662     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.12.003     Document Type: Article

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