GW1929 inhibits α7 nAChR expression through PPARγ-independent activation of p38 MAPK and inactivation of PI3-K/mTOR: The role of Egr-1

Cellular Signalling

Volumn 26, Issue 4, 2014, Pages 730-739

  Hahn, Swei Sunny ^a   Tang, Qing ^a   Zheng, Fang ^a   Zhao, Shunyu ^a   Wu, JingJing ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

7nAchR; Egr 1; GW1929; Human lung adenocarcinoma cells; P38 MPAK; PPAR

Indexed keywords

4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; ACETYLCHOLINE; BUNGAROTOXIN RECEPTOR; DNA; EARLY GROWTH RESPONSE FACTOR 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; N (2 BENZOYLPHENYL) O [2 (METHYL 2 PYRIDINYLAMINO)ETHYL]TYROSINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION;

EGR-1; GW1929; HUMAN LUNG ADENOCARCINOMA CELLS; P38 MPAK; PPARΓ; Α7NACHR;

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANILIDES; BENZOPHENONES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; EARLY GROWTH RESPONSE PROTEIN 1; ENZYME ACTIVATION; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PPAR GAMMA; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TYROSINE;

EID: 84892871401     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.12.019     Document Type: Article

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