A biomarker panel and psychological morbidity differentiates the irritable bowel syndrome from health and provides novel pathophysiological leads

Alimentary Pharmacology and Therapeutics

Volumn 39, Issue 4, 2014, Pages 426-437

  Jones, M P ^a   Chey, W D ^b   Singh, S ^c   Gong, H ^c   Shringarpure, R ^c   Hoe, N ^c   Chuang, E ^c   Talley, N J ^d  

^a MACQUARIE UNIVERSITY   (Australia)

^b UNIVERSITY OF MICHIGAN   (United States)

^c Prometheus Laboratories Inc   (United States)

^d UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

ADULT; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST; DISEASE CLASSIFICATION; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MORBIDITY; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; PSYCHOLOGICAL ASPECT; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY;

ADULT; ANXIETY; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DEPRESSION; FEMALE; GASTROINTESTINAL DISEASES; GENE EXPRESSION; HUMANS; IRRITABLE BOWEL SYNDROME; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84892870176     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/apt.12608     Document Type: Article

References (43)

1. Cremonini F, Talley N,. Irritable bowel syndrome: epidemiology, natural history, health-care seeking and emerging risk factors. Gastroenterol Clin North Am 2005; 34: 189-204.
2. Thompson W, Longstreth G, Drossman D, et al,. Functional bowel disorders and functional abdominal pain. Gut 1999; 45 (Suppl 2): II43-7.
3. Brandt L, Chey W, Foxx-Orenstein A, et al,. An evidence-based position statement on the management of irritable bowel syndrome. Am J Gastroenterol 2009; 104 (Suppl 1): S1-35.
4. Chey W, Nojkov B, Rubenstein J, et al,. The yield of colonoscopy in patients with non-constipated irritable bowel syndrome: results from a prospective, controlled US trial. Am J Gastroenterol 2010; 105: 859-65.
5. Spiegel B, Farid M, Esrailian E, et al,. Is irritable bowel syndrome a diagnosis of exclusion?: a survey of primary care providers, gastroenterologists, and IBS experts. Am J Gastroenterol 2010; 105: 848-58.
6. Lacy B, Rosemore J, Robertson D, et al,. Physicians' attitudes and practices in the evaluation and treatment of irritable bowel syndrome. Scand J Gastroenterol 2006; 41: 892-902.
7. Cash B, Schoenfeld P, Chey W,. The utility of diagnostic tests in irritable bowel syndrome patients: a systematic review. Am J Gastroenterol 2002; 97: 2812-9.
8. Schmulson M, Chang L,. Diagnostic approach to the patient with irritable bowel syndrome. Am J Med 1999; 107 (5A): 20S-6S.
9. Tillisch K, &, Chang L, Diagnosis and treatment of irritable bowel syndrome: state of the art. Curr Gastroenterol Rep 2005; 7: 249-56.
10. Gershon M,. Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. J Clin Gastroenterol 2005; 39 (5, Suppl 3): S184-93.
11. Coates M, Mahoney C, Linden D, et al,. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 2004; 126: 1657-64.
12. Mawe G, Coates M, Moses P,. Review article: intestinal serotonin signalling in irritable bowel syndrome. Aliment Pharmacol Ther 2006; 23: 1067-76.
13. Rõka R, Rosztõczy A, Leveque M, et al,. A pilot study of fecal serine-protease activity: a pathophysiologic factor in diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol 2007; 5: 550-5.
14. Barbara G, Wang B, Stanghellini V, et al,. Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology 2007; 132: 26-37.
15. Guilarte M, Santos J, Torres Id, et al,. Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut 2007; 56: 203-9.
16. Barbara G, Stanghellini V, Giorgio Rd, et al,. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004; 126: 693-702.
17. O'Sullivan M, Clayton N, Breslin N, et al,. Increased mast cells in the irritable bowel syndrome. Neurogastroenterol Motil 2000; 12: 449-57.
18. Feng B, La JH, Schwartz ES, Gebhart GF,. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 2012; 8: 2012.
19. Spiller R, Garsed K,. Postinfectious irritable bowel syndrome. Gastroenterology 2009; 136: 1979-88.
20. Videlock EJ, Adeyemo M, Licudine A, et al,. Childhood trauma is associated with hypothalamic-pituitary-adrenal axis responsiveness in irritable bowel syndrome. Gastroenterology 2009; 137: 1954-62.
21. Liebregts T, Adam B, Bredack C, et al,. Immune activation in patients with irritable bowel syndrome. Gastroenterology 2007; 132: 913-20.
22. Talley NJ, Fodor AA,. Bugs, stool, and the irritable bowel syndrome: too much is as bad as too little? Gastroenterology 2011; 141: 1555-9.
23. Aerssens J, Camilleri M, Talloen W, et al,. Alterations in mucosal immunity identified in the Colon of patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2008; 6: 194-205.
24. Harris C, Ma T, Leighton J, et al,. Novel genomic biomarkers that differentiate between irritable bowel syndrome and normal patients using peripheral blood specimens. Am J Gastroenterol 2008; 103: S468.
25. Talley N, Spiller R,. Irritable bowel syndrome: a little understood organic bowel disease? Lancet 2002; 360: 555-64.
26. Walker E, Roy-Byrne P, Katon W,. Irritable bowel syndrome and psychiatric illness. Am J Psychiatry 1990; 147: 565-72.
27. Gros D, Antony M, McCabe R, et al,. Frequency and severity of the symptoms of irritable bowel syndrome across the anxiety disorders and depression. J Anxiety Disord 2009; 23: 290-6.
28. Drossman D,. Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome? Am J Med 1999; 107 (suppl): 41-50.
29. Ditto B, Miller S, Barr R,. A one-hour active coping stressor reduces small bowel transit time in healthy young adults. Psychosom Med 1998; 60: 7-10.
30. Fossey M, Lydiard R,. Anxiety and the gastrointestinal system. Psychiatr Med 1990; 8: 175-86.
31. Drossman D,. Gastrointestinal illness and the biopsychosocial model. Psychosom Med 1998; 60: 258-67.
32. Lembo A, Neri B, Tolley J, et al,. Use of serum biomarkers in a diagnostic test for irritable bowel syndrome. Aliment Pharmacol Ther 2009; 29: 834-42.
33. Whitehead W, Palsson O, Levy R, et al,. Comorbidity in irritable bowel syndrome. Am J Gastroenterol 2007; 102: 2767-76.
34. Francis CY, Morris J, Whorwell PJ,. The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharmacol Ther 1997; 11: 395-402.
35. Drossman DA, Li Z, Toner BB, et al,. Functional bowel disorders: a multicenter comparison of health status and development of illness severity index. Dig Dis Sci 1995; 40: 986-95.
36. Zigmond A, Snaith R,. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67: 361-70.
37. Kroenke K, Spitzer R, Williams J,. The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosom Med 2002; 64: 258-66.
38. Benjamini Y, Hochberg Y,. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B 1995; 57: 289-300.
39. Vivinus-Nébot M, Dainese R, Anty R, et al,. Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells. Am J Gastroenterol 2012; 107: 75-81.
40. Walker M, Warwick A, Ung C, et al,. The role of eosinophils and mast cells in intestinal functional disease. Curr Gastroenterol Rep 2011; 13: 323-30.
41. Ford A, Talley N,. Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review. J Gastroenterol 2011; 46: 421-31.
42. Ford A, Talley N,. IBS in 2010: advances in pathophysiology, diagnosis and treatment. Nat Rev Gastroenterol Hepatol 2011; 8: 76-8.
43. Bossuyt P, Reitsma J, Bruns D, et al,. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Ann Intern Med 2003; 138: W1-12.