Childhood Trauma Is Associated With Hypothalamic-Pituitary-Adrenal Axis Responsiveness in Irritable Bowel Syndrome

Gastroenterology

Volumn 137, Issue 6, 2009, Pages 1954-1962

  Videlock, Elizabeth J ^a   Adeyemo, Mopelola ^a   Licudine, Arlene ^a   Hirano, Miyoshi ^a   Ohning, Gordon ^a,b   Mayer, Minou ^a   Mayer, Emeran A ^a   Chang, Lin ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHILDHOOD INJURY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISTRESS SYNDROME; FEMALE; GASTROINTESTINAL DISEASE; GASTROINTESTINAL SYMPTOM; GENDER; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IRRITABLE COLON; MALE; PRIORITY JOURNAL; QUALITY OF LIFE; SIGMOIDOSCOPY;

EID: 70749155622     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.08.058     Document Type: Article

References (63)

1. Mayer E.A., Naliboff B.D., Chang L., et al. V. Stress and irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 280 (2001) G519-G524
2. Spiller R.C. Postinfectious irritable bowel syndrome. Gastroenterology 124 (2003) 1662-1671
3. Gwee K.A., Leong Y.L., Graham C., et al. The role of psychological and biological factors in postinfective gut dysfunction. Gut 44 (1999) 400-406
4. Posserud I., Agerforz P., Ekman R., et al. Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. Gut 53 (2004) 1102-1108
5. Alonso C., Guilarte M., Vicario M., et al. Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation. Gastroenterology 135 (2008) 163e1-172e1
6. Tillisch K., Mayer E.A., Labus J.S., et al. Sex specific alterations in autonomic function among patients with irritable bowel syndrome. Gut 54 (2005) 1396-1401
7. Cain K.C., Jarrett M.E., Burr R.L., et al. Heart rate variability is related to pain severity and predominant bowel pattern in women with irritable bowel syndrome. Neurogastroenterol Motil 19 (2007) 110-118
8. Chang L., Sundaresh S., Elliott J., et al. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterol Motil 21 (2009) 149-159
9. Patacchioli F.R., Angelucci L., Dellerba G., et al. Actual stress, psychopathology and salivary cortisol levels in the irritable bowel syndrome (IBS). J Endocrinol Invest 24 (2001) 173-177
10. Heitkemper M., Jarrett M., Cain K., et al. Increased urine catecholamines and cortisol in women with irritable bowel syndrome. Am J Gastroenterol 91 (1996) 906-913
11. Dinan T.G., Quigley E.M., Ahmed S.M., et al. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?. Gastroenterology 130 (2006) 304-311
12. Bohmelt A.H., Nater U.M., Franke S., et al. Basal and stimulated hypothalamic-pituitary-adrenal axis activity in patients with functional gastrointestinal disorders and healthy controls. Psychosom Med 67 (2005) 288-294
13. Ehlert U., Nater U.M., and Bohmelt A. High and low unstimulated salivary cortisol levels correspond to different symptoms of functional gastrointestinal disorders. J Psychosom Res 59 (2005) 7-10
14. Elsenbruch S., Lucas A., Holtmann G., et al. Public speaking stress-induced neuroendocrine responses and circulating immune cell redistribution in irritable bowel syndrome. Am J Gastroenterol 101 (2006) 2300-2307
15. Tak L.M., Bakker S.J., and Rosmalen J.G. Dysfunction of the hypothalamic-pituitary-adrenal axis and functional somatic symptoms: a longitudinal cohort study in the general population. Psychoneuroendocrinology 34 (2009) 869-877
16. Drossman D.A., Leserman J., Nachman G., et al. Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Ann Intern Med 113 (1990) 828-833
17. Chitkara D.K., van Tilburg M.A., Blois-Martin N., et al. Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review. Am J Gastroenterol 103 (2008) 765-774 quiz 775
18. Talley N.J., Fett S.L., Zinsmeister A.R., et al. Gastrointestinal tract symptoms and self-reported abuse: a population-based study. Gastroenterology 107 (1994) 1040-1049
19. Salmon P., Skaife K., and Rhodes J. Abuse, dissociation, and somatization in irritable bowel syndrome: towards an explanatory model. J Behav Med 26 (2003) 1-18
20. Ross C.A. Childhood sexual abuse and psychosomatic symptoms in irritable bowel syndrome. J Child Sex Abus 14 (2005) 27-38
21. Heim C., and Nemeroff C.B. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry 49 (2001) 1023-1039
22. Bremner J.D., Bolus R., and Mayer E.A. Psychometric properties of the Early Trauma Inventory-Self Report. J Nerv Ment Dis 195 (2007) 211-218
23. Dube S.R., Felitti V.J., Dong M., et al. The impact of adverse childhood experiences on health problems: evidence from four birth cohorts dating back to 1900. Prev Med 37 (2003) 268-277
24. McEwen B.S. Understanding the potency of stressful early life experiences on brain and body function. Metabolism 57 Suppl 2 (2008) S11-S15
25. Sanchez M.M. The impact of early adverse care on HPA axis development: nonhuman primate models. Horm Behav 50 (2006) 623-631
26. Turner-Cobb J.M. Psychological and stress hormone correlates in early life: a key to HPA-axis dysregulation and normalisation. Stress 8 (2005) 47-57
27. Heim C., Newport D.J., Bonsall R., et al. Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. Am J Psychiatry 158 (2001) 575-581
28. Rao U., Hammen C., Ortiz L.R., et al. Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents. Biol Psychiatry 64 (2008) 521-526
29. Thompson W.G., Longstreth G.F., Drossman D.A., et al. Functional bowel disorders and functional abdominal pain. Gut 45 Suppl 2 (1999) II43-II47
30. Munakata J., Naliboff B., Harraf F., et al. Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome. Gastroenterology 112 (1997) 55-63
31. Zigmond A.S., and Snaith R.P. The hospital anxiety and depression scale. Acta Psychiatr Scand 67 (1983) 361-370
32. Longstreth G.F., Bolus R., Naliboff B., et al. Impact of irritable bowel syndrome on patients' lives: development and psychometric documentation of a disease-specific measure for use in clinical trials. Eur J Gastroenterol Hepatol 17 (2005) 411-420
33. Green B.L. Trauma history questionnaire. In: Stamm B., and Varra E. (Eds). Measurement of stress, trauma and adaptation (1996), Sidran, Lutherville, MD 366-368
34. Spitzer R., Williams J., and Gibbon M. Structured clinical interview for DSM-III-R (1990), American Psychiatric Press, Arlington, VA
35. McCracken J.T., and Poland R.E. Saliva and serum cortisol dynamics following intravenous dexamethasone in normal volunteers. Life Sci 45 (1989) 1781-1785
36. Poland R.E., and Rubin R.T. Saliva cortisol levels following dexamethasone administration in endogenously depressed patients. Life Sci 30 (1982) 177-181
37. Matthews J.N., Altman D.G., Campbell M.J., et al. Analysis of serial measurements in medical research. BMJ 300 (1990) 230-235
38. Pruessner J.C., Kirschbaum C., Meinlschmid G., et al. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 28 (2003) 916-931
39. Kudielka B.M., Hellhammer D.H., and Wüst S. Why do we respond so differently?. Reviewing determinants of human salivary cortisol responses to challenge. Psychoneuroendocrinology 34 (2009) 2-18
40. Tyrka A.R., Wier L., Price L.H., et al. Childhood parental loss and adult hypothalamic-pituitary-adrenal function. Biol Psychiatry 63 (2008) 1147-1154
41. Gareau M.G., Jury J., Yang P.C., et al. Neonatal maternal separation causes colonic dysfunction in rat pups including impaired host resistance. Pediatr Res 59 (2006) 83-88
42. O'Mahony S.M., Marchesi J.R., Scully P., et al. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry 65 (2009) 263-267
43. Elzinga B.M., Roelofs K., Tollenaar M.S., et al. Diminished cortisol responses to psychosocial stress associated with lifetime adverse events. A study among healthy young subjects. Psychoneuroendocrinology 33 (2008) 227-237
44. Carpenter L.L., Carvalho J.P., Tyrka A.R., et al. Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment. Biol Psychiatry 62 (2007) 1080-1087
45. Rinne T., de Kloet E.R., Wouters L., et al. Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse. Biol Psychiatry 52 (2002) 1102-1112
46. Wolffe A.P., and Matzke M.A. Epigenetics: regulation through repression. Science 286 (1999) 481-486
47. Meaney M.J., Szyf M., and Seckl J.R. Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends Mol Med 13 (2007) 269-277
48. Fish E. Epigenetic programming of stress responses through variations in maternal care. Ann N Y Acad Sci 1036 (2004) 167-180
49. McGowan P.O., Sasaki A., D'Alessio A.C., et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12 (2009) 342-348
50. Anda R.F., Felitti V.J., Bremner J.D., et al. The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology. Eur Arch Psychiatry Clin Neurosci 256 (2006) 174-186
51. Creed F., Tomenson B., Guthrie E., et al. The relationship between somatisation and outcome in patients with severe irritable bowel syndrome. J Psychosom Res 64 (2008) 613-620
52. Bremner J.D., Vythilingam M., Anderson G., et al. Assessment of the hypothalamic-pituitary-adrenal axis over a 24-hour diurnal period and in response to neuroendocrine challenges in women with and without childhood sexual abuse and posttraumatic stress disorder. Biol Psychiatry 54 (2003) 710-718
53. Bengtson M.B., Ronning T., Vatn M.H., et al. Irritable bowel syndrome in twins: genes and environment. Gut 55 (2006) 1754-1759
54. Anand K.J., Runeson B., and Jacobson B. Gastric suction at birth associated with long-term risk for functional intestinal disorders in later life. J Pediatr 144 (2004) 449-454
55. Coutinho S.V., Plotsky P.M., Sablad M., et al. Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am J Physiol Gastrointest Liver Physiol 282 (2002) G307-G316
56. Walter S.A., Aardal-Eriksson E., Thorell L.H., et al. Pre-experimental stress in patients with irritable bowel syndrome: high cortisol values already before symptom provocation with rectal distensions. Neurogastroenterol Motil 18 (2006) 1069-1077
57. Meaney M.J., Diorio J., Francis D., et al. Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Dev Neurosci 18 (1996) 49-72
58. Mayer E.A., and Collins S.M. Evolving pathophysiologic models of functional gastrointestinal disorders. Gastroenterology 122 (2002) 2032-2048
59. Mayer E.A., and Bushnell M.C. Functional pain syndromes: presentation and pathophysiology (2009), International Association for the Study of Pain, Seattle, WA
60. Weissbecker I., Floyd A., Dedert E., et al. Childhood trauma and diurnal cortisol disruption in fibromyalgia syndrome. Psychoneuroendocrinology 31 (2006) 312-324
61. Heim C., Ehlert U., Hanker J.P., et al. Abuse-related posttraumatic stress disorder and alterations of the hypothalamic-pituitary-adrenal axis in women with chronic pelvic pain. Psychosom Med 60 (1998) 309-318
62. Whitehead W.E., Crowell M.D., Robinson J.C., et al. Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction. Gut 33 (1992) 825-830
63. Longstreth G.F., Thompson W.G., Chey W.D., et al. Functional bowel disorders. Gastroenterology 130 (2006) 1480-1491