Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice

Developmental Biology

Volumn 386, Issue 2, 2014, Pages 395-407

  Balemans, Monique C M ^a   Ansar, Muhammad ^a,b   Oudakker, Astrid R ^a,c   van Caam, Arjan P M ^a   Bakker, Brenda ^a   Vitters, Elly L ^a   van der Kraan, Peter M ^a   de Bruijn, Diederik R H ^a   Janssen, Sanne M ^a   Kuipers, Arthur J ^a   Huibers, Manon M H ^a   Maliepaard, Eliza M ^a   Walboomers, X Frank ^d   Benevento, Marco ^c   Nadif Kasri, Nael ^c   Kleefstra, Tjitske ^a   Zhou, Huiqing ^a   Van der Zee, Catharina E E M ^a   van Bokhoven, Hans ^a,c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b KING EDWARD MEDICAL UNIVERSITY   (Pakistan)

^c RADBOUD UNIVERSITY   (Netherlands)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Col11a; Col22a; Dimethylation; Dmp1; Ehmt1; Ehmt1 heterozygous knockout mice; G9a like protein; GLP; H3K9; KMT1D; MRNA; Postnatal development; Runx2; Skull and nose bone

Indexed keywords

EUCHROMATIN HISTONE METHYLTRANSFERASE 1; HISTONE H3; HISTONE METHYLTRANSFERASE; MESSENGER RNA; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BRACHYCEPHALY; CLINICAL FEATURE; CONTROLLED STUDY; CRANIOFACIAL MALFORMATION; DEVELOPMENTAL DISORDER; DISEASE ASSOCIATION; DISEASE MODEL; EPIGENETICS; EYE MOVEMENT; FEMALE; GENE EXPRESSION; HAPLOINSUFFICIENCY; HISTONE METHYLATION; HYPERTELORISM; IMMUNOHISTOCHEMISTRY; INCISOR; INTELLECTUAL IMPAIRMENT; KLEEFSTRA SYNDROME; MALE; MOTOR COORDINATION; MOUSE; MUSCLE HYPOTONIA; MUSCLE STRENGTH; NONHUMAN; NOSE MALFORMATION; PATHOGENESIS; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROMOTER REGION; TOOTH ERUPTION; UPREGULATION; WILD TYPE;

ANIMALIA; CRANIA; MUS;

COL11A; COL22A; DIMETHYLATION; DMP1; EHMT1; EHMT1 HETEROZYGOUS KNOCKOUT MICE; G9A-LIKE PROTEIN; GLP; H3K9; KMT1D; MRNA; POSTNATAL DEVELOPMENT; RUNX2; SKULL AND NOSE BONE;

ANALYSIS OF VARIANCE; ANIMALS; BONE AND BONES; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 9; CRANIOFACIAL ABNORMALITIES; DEVELOPMENTAL DISABILITIES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART DEFECTS, CONGENITAL; HISTONE-LYSINE N-METHYLTRANSFERASE; INTELLECTUAL DISABILITY; MALE; MICE; MICE, KNOCKOUT; MUSCLE HYPOTONIA; OSTEOPONTIN; REAL-TIME POLYMERASE CHAIN REACTION; SKULL;

EID: 84892868431     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2013.12.016     Document Type: Article

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