Human platelet antigens - 2013

Vox Sanguinis

Volumn 106, Issue 2, 2014, Pages 93-102

  Curtis, B R ^a   Mcfarland, J G ^a  

^a Platelet and Neutrophil Immunology Laboratory   (United States)

Author keywords

Neonatal alloimmune thrombocytopenia; Platelet antigens; Platelet refractoriness

Indexed keywords

ALLOANTIGEN; ALPHA2 INTEGRIN; BETA1 INTEGRIN; BLOOD GROUP ANTIGEN; CD36 ANTIGEN; GLYCOPROTEIN; GLYCOPROTEIN IB; GLYCOPROTEIN VI; THROMBIN RECEPTOR; THROMBOCYTE ANTIGEN;

ANTIBODY SPECIFICITY; ARTICLE; BLOOD GROUP ABO SYSTEM; BLOOD TRANSFUSION REACTION; CAUCASIAN; GENE FREQUENCY; HEMOSTASIS; HLA SYSTEM; HUMAN; INFLAMMATION; NEONATAL ALLOIMMUNE THROMBOCYTOPENIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURPURA; THROMBOCYTE DISORDER;

NEONATAL ALLOIMMUNE THROMBOCYTOPENIA; PLATELET ANTIGENS; PLATELET REFRACTORINESS;

ALLELES; ANTIGENS, HUMAN PLATELET; GENOTYPING TECHNIQUES; HUMANS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET MEMBRANE GLYCOPROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84892845161     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/vox.12085     Document Type: Article

References (99)

1. Leslie M: Cell biology. Beyond clotting: the powers of platelets. Science 2010; 328: 562-564
2. Semple JW, Italiano JE Jr, Freedman J: Platelets and the immune continuum. Nat Rev Immunol 2011; 11: 264-274
3. Pacheco LD, Berkowitz RL, Moise KJ Jr, et al.: Fetal and neonatal alloimmune thrombocytopenia: a management algorithm based on risk stratification. Obstet Gynecol 2011; 118: 1157-1163
4. Mueller-Eckhardt C, Kiefel V, Grubert A, et al.: 348 cases of suspected neonatal alloimmune thrombocytopenia. Lancet 1989; 1: 363-366
5. McFarland JG: Post-transfusion purpura; in: Popovsky MA (ed.): Transfusion Reactions. Bethesda, AABB Press, 2007: 275-300
6. Novotny VM: Prevention and management of platelet transfusion refractoriness. Vox Sang 1999; 76: 1-13
7. Valentin N, Vergracht A, Bignon JD, et al.: HLA-DRw52a is involved in alloimmunization against PL-A1 antigen. Hum Immunol 1990; 27: 73-79
8. Decary F, L'Abbe D, Tremblay L, et al.: The immune response to the HPA-1a antigen: association with HLA-DRw52a. Transfus Med 1991; 1: 55-62
9. L'Abbe D, Tremblay L, Filion M, et al.: Alloimmunization to platelet antigen HPA-1a (PIA1) is strongly associated with both HLA-DRB3*0101 and HLA-DQB1*0201. Hum Immunol 1992; 34: 107-114
10. Loewenthal R, Rosenberg N, Kalt R, et al.: Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia. Transfusion 2013; 53: 344-352
11. Socher I, Zwingel C, Santoso S, et al.: Heterogeneity of HPA-3 alloantibodies: consequences for the diagnosis of alloimmune thrombocytopenic syndromes. Transfusion 2008; 48: 463-472
12. Harrison CR, Curtis BR, McFarland JG, et al.: Severe neonatal alloimmune thrombocytopenia caused by antibodies to human platelet antigen 3a (Baka) detectable only in whole platelet assays. Transfusion 2003; 43: 1398-1402
13. Noris P, Simsek S, de Bruijne-Admiraal LG, et al.: Max(a), a new low-frequency platelet-specific antigen localized on glycoprotein IIb, is associated with neonatal alloimmune thrombocytopenia. Blood 1995; 86: 1019-1026
14. Peterson JA, Gitter ML, Kanack A, et al.: New low-frequency platelet glycoprotein polymorphisms associated with neonatal alloimmune thrombocytopenia. Transfusion 2010; 50: 324-333
15. Jallu V, Dusseaux M, Kaplan C: A new Ser472Asn (Cab2(a+)) polymorphism localized within the alphaIIb "thigh" domain is involved in neonatal thrombocytopenia. Transfusion 2011; 51: 393-400
16. Jallu V, Bertrand G, Bianchi F, et al.: The alphaIIb p.Leu841Met (Cab3(a+)) polymorphism results in a new human platelet alloantigen involved in neonatal alloimmune thrombocytopenia. Transfusion 2012; 53: 554-563
17. Peyruchaud O, Bourre F, Morel-Kopp MC, et al.: HPA-10w(b) (La(a)): genetic determination of a new platelet-specific alloantigen on glycoprotein IIIa and its expression in COS-7 cells. Blood 1997; 89: 2422-2428
18. McFarland JG, Blanchette V, Collins J, et al.: Neonatal alloimmune thrombocytopenia due to a new platelet-specific alloantibody. Blood 1993; 81: 3318-3323
19. Kekomaki R, Jouhikainen T, Ollikainen J, et al.: A new platelet alloantigen, Tua, on glycoprotein IIIa associated with neonatal alloimmune thrombocytopenia in two families. Br J Haematol 1993; 83: 306-310
20. Sachs UJ, Bakchoul T, Eva O, et al.: A point mutation in the EGF-4 domain of beta(3) integrin is responsible for the formation of the Sec(a) platelet alloantigen and affects receptor function. Thromb Haemost 2012; 107: 80-87
21. Kroll H, Kiefel V, Santoso S, et al.: Sra, a private platelet antigen on glycoprotein IIIa associated with neonatal alloimmune thrombocytopenia. Blood 1990; 76: 2296-2302
22. Simsek S, Vlekke AB, Kuijpers RW, et al.: A new private platelet antigen, Groa, localized on glycoprotein IIIa, involved in neonatal alloimmune thrombocytopenia. Vox Sang 1994; 67: 302-306
23. Santoso S, Kiefel V, Richter IG, et al.: A functional platelet fibrinogen receptor with a deletion in the cysteine-rich repeat region of the beta(3) integrin: the Oe(a) alloantigen in neonatal alloimmune thrombocytopenia. Blood 2002; 99: 1205-1214
24. Jallu V, Meunier M, Brement M, et al.: A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia. Blood 2002; 99: 4449-4456
25. Kekomaki R, Raivio P, Kero P: A new low-frequency platelet alloantigen, Vaa, on glycoprotein IIbIIIa associated with neonatal alloimmune thrombocytopenia. Transfus Med 1992; 2: 27-33
26. Peterson JA, Pechauer SM, Gitter ML, et al.: New platelet glycoprotein polymorphisms causing maternal immunization and neonatal alloimmune thrombocytopenia. Transfusion 2012; 52: 1117-1124
27. Kuijpers RW, Simsek S, Faber NM, et al.: Single point mutation in human glycoprotein IIIa is associated with a new platelet-specific alloantigen (Mo) involved in neonatal alloimmune thrombocytopenia. Blood 1993; 81: 70-76
28. Koh Y, Ishii H, Amakishi E, et al.: The first two cases of neonatal alloimmune thrombocytopenia associated with the low-frequency platelet antigen HPA-21bw (Nos) in Japan. Transfusion 2012; 52: 1468-1475
29. Peterson JA, Pechauer SM, Gitter ML, et al.: The human platelet antigen-21bw is relatively common among Asians and is a potential trigger for neonatal alloimmune thrombocytopenia. Transfusion 2012; 52: 915-916
30. Peterson JA, Balthazor SM, Curtis BR, et al.: Maternal alloimmunization against the rare platelet-specific antigen HPA-9b (Max a) is an important cause of neonatal alloimmune thrombocytopenia. Transfusion 2005; 45: 1487-1495
31. Kaplan C, Porcelijn L, Vanlieferinghen P, et al.: Anti-HPA-9bw (Maxa) fetomaternal alloimmunization, a clinically severe neonatal thrombocytopenia: difficulties in diagnosis and therapy and report on eight families. Transfusion 2005; 45: 1799-1803
32. Kovacsovics TJ, Hartwig JH: Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation. Blood 1996; 87: 618-629
33. Kiefel V, Vicariot M, Giovangrandi Y, et al.: Alloimmunization against Iy, a low-frequency antigen on platelet glycoprotein Ib/IX as a cause of severe neonatal alloimmune thrombocytopenic purpura. Vox Sang 1995; 69: 250-254
34. Nurden AT, Freson K, Seligsohn U: Inherited platelet disorders. Haemophilia 2012; 18(Suppl 4):154-160
35. Nurden P, Nurden AT: Congenital disorders associated with platelet dysfunctions. Thromb Haemost 2008; 99: 253-263
36. Tobelem G, Levy-Toledano S, Bredoux R, et al.: New approaches to determination of specific functions of platelet membrane sites. Nature 1976; 263: 427-429
37. Corral J, Rivera J, Gonzalez-Conejero R, et al.: The number of platelet glycoprotein Ia molecules is associated with the genetically linked 807 C/T and HPA-5 polymorphisms. Transfusion 1999; 39: 372-378
38. Santoso S, Amrhein J, Hofmann HA, et al.: A point mutation Thr(799)Met on the alpha(2) integrin leads to the formation of new human platelet alloantigen Sit(a) and affects collagen-induced aggregation. Blood 1999; 94: 4103-4111
39. Bertrand G, Jallu V, Saillant D, et al.: The new platelet alloantigen Cab a: a single point mutation Gln 716 His on the alpha 2 integrin. Transfusion 2009; 49: 2076-2083
40. Kroll H, Feldmann K, Zwingel C, et al.: A new platelet alloantigen, Swi(a), located on glycoprotein Ia identified in a family with fetal and neonatal alloimmune thrombocytopenia. Transfusion 2011; 51: 1745-1754
41. Metcalfe P, Watkins NA, Ouwehand WH, et al.: Nomenclature of human platelet antigens. Vox Sang 2003; 85: 240-245
42. Berry JE, Murphy CM, Smith GA, et al.: Detection of Gov system antibodies by MAIPA reveals an immunogenicity similar to the HPA-5 alloantigens. Br J Haematol 2000; 110: 735-742
43. Ertel K, Al-Tawil M, Santoso S, et al.: Relevance of the HPA-15 (Gov) polymorphism on CD109 in alloimmune thrombocytopenic syndromes. Transfusion 2005; 45: 366-373
44. Mandelbaum M, Koren D, Eichelberger B, et al.: Frequencies of maternal platelet alloantibodies and autoantibodies in suspected fetal/neonatal alloimmune thrombocytopenia, with emphasis on human platelet antigen-15 alloimmunization. Vox Sang 2005; 89: 39-43
45. Ghevaert C, Campbell K, Walton J, et al.: Management and outcome of 200 cases of fetomaternal alloimmune thrombocytopenia. Transfusion 2007; 47: 901-910
46. Silverstein RL, Li W, Park YM, et al.: Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis. Trans Am Clin Climatol Assoc 2010; 121: 206-220
47. Aitman TJ, Cooper LD, Norsworthy PJ, et al.: Malaria susceptibility and CD36 mutation. Nature 2000; 405: 1015-1016
48. Curtis BR, Ali S, Glazier AM, et al.: Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature. Transfusion 2002; 42: 1173-1179
49. Rac ME, Safranow K, Poncyljusz W: Molecular basis of human CD36 gene mutations. Mol Med 2007; 13: 288-296
50. Bierling P, Godeau B, Fromont P, et al.: Posttransfusion purpura-like syndrome associated with CD36 (Naka) isoimmunization. Transfusion 1995; 35: 777-782
51. Ikeda H, Mitani T, Ohnuma M, et al.: A new platelet-specific antigen, Naka, involved in the refractoriness of HLA-matched platelet transfusion. Vox Sang 1989; 57: 213-217
52. Saw CL, Szykoluk H, Curtis BR, et al.: Two cases of platelet transfusion refractoriness associated with anti-CD36. Transfusion 2010; 50: 2638-2642
53. Boylan B, Chen H, Rathore V, et al.: Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface. Blood 2004; 104: 1350-1355
54. Akiyama M, Kashiwagi H, Todo K, et al.: Presence of platelet-associated anti-glycoprotein (GP)VI autoantibodies and restoration of GPVI expression in patients with GPVI deficiency. J Thromb Haemost 2009; 7: 1373-1383
55. Dunstan RA, Simpson MB: Heterogeneous distribution of antigens on human platelets demonstrated by fluorescence flow cytometry. Br J Haematol 1985; 61: 603-609
56. Curtis BR, Edwards JT, Hessner MJ, et al.: Blood group A and B antigens are strongly expressed on platelets of some individuals. Blood 2000; 96: 1574-1581
57. Ogasawara K, Ueki J, Takenaka M, et al.: Study on the expression of ABH antigens on platelets. Blood 1993; 82: 993-999
58. Santoso S, Kiefel V, Mueller-Eckhardt C: Blood group A and B determinants are expressed on platelet glycoproteins IIa, IIIa, and Ib. Thromb Haemost 1991; 65: 196-201
59. Dunstan RA: Use of fluorescence flow cytometry to study the binding of various ligands to platelets. J Histochem Cytochem 1985; 33: 1176-1179
60. Aster RH: Effect of anticoagulant and ABO incompatibility on recovery of transfused human platelets. Blood 1965; 26: 732-743
61. Pfisterer H, Thierfelder S, Stich W: ABO Rh blood groups and platelet transfusion. Blut 1968; 17: 1-5
62. Skogen B, Rossebo Hansen B, Husebekk A, et al.: Minimal expression of blood group A antigen on thrombocytes from A2 individuals. Transfusion 1988; 28: 456-459
63. Curtis BR, Fick A, Lochowicz AJ, et al.: Neonatal alloimmune thrombocytopenia associated with maternal-fetal incompatibility for blood group B. Transfusion 2008; 48: 358-364
64. Curtis BR, McFarland JG: Platelet immunology and alloimmunization; in Simon TL, Dzik WH, Snyder E, Stowell CP, Strauss RG (eds): Rossi's Principles of Transfusion Medicine. Philadelphia, Lippincott Williams & Wilkins, 2008: 203-217
65. Pereira J, Cretney C, Aster RH: Variation of class I HLA antigen expression among platelet density cohorts: a possible index of platelet age? Blood 1988; 71: 516-519
66. Kao KJ, Scornik JC, McQueen CF: Evaluation of individual specificities of class I HLA on platelets by a newly developed monoclonal antibody. Hum Immunol 1990; 27: 285-297
67. Leukocyte reduction and ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions The Trial to Reduce Alloimmunization to Platelets Study Group. N Engl J Med. 1997; 337: 1861-1869
68. Kakaiya RM, Triulzi DJ, Wright DJ, et al.: Prevalence of HLA antibodies in remotely transfused or alloexposed volunteer blood donors. Transfusion 2010; 50: 1328-1334
69. Triulzi DJ, Kleinman S, Kakaiya RM, et al.: The effect of previous pregnancy and transfusion on HLA alloimmunization in blood donors: implications for a transfusion-related acute lung injury risk reduction strategy. Transfusion 2009; 49: 1825-1835
70. McGann MJ, Procter JL, Honda J, et al.: Comparison of human platelet antigen (HPA)-1a typing by solid phase red cell adherence to HPA-1 allotypes determined by allele-specific restriction enzyme analysis. Immunohematology 2000; 16: 68-73
71. Mohabir LA, Porter L: Semiautomation of platelet HPA-1a phenotyping by SPRCA and ELISA. Immunohematology 1997; 13: 44-48
72. Garner SF, Smethurst PA, Merieux Y, et al.: A rapid one-stage whole-blood HPA-1a phenotyping assay using a recombinant monoclonal IgG1 anti-HPA-1a. Br J Haematol 2000; 108: 440-447
73. Curtis BR: Genotyping for human platelet alloantigen polymorphisms: applications in the diagnosis of alloimmune platelet disorders. Semin Thromb Hemost 2008; 34: 539-548
74. Hurd CM, Cavanagh G, Schuh A, et al.: Genotyping for platelet-specific antigens: techniques for the detection of single nucleotide polymorphisms. Vox Sang 2002; 83: 1-12
75. Curtis B, McFarland J: Detection and identification of platelet antibodies and antigens in the clinical laboratory. Immunohematol 2009; 25: 125-135
76. Skogen B, Bellissimo DB, Hessner MJ, et al.: Rapid determination of platelet alloantigen genotypes by polymerase chain reaction using allele-specific primers. Transfusion 1994; 34: 955-960
77. Sachs UJ, Kiefel V, Kroll H, et al.: Report on the 15th International Society of Blood Transfusion platelet immunology workshop. Vox Sang 2012; 103: 343-351
78. Peterson JA, Kanack A, Nayak D, et al.: Prevalence and clinical significance of low-avidity HPA-1a antibodies in women exposed to HPA-1a during pregnancy. Transfusion 2013; 53: 1309-1318
79. Le Toriellec E, Chenet C, Kaplan C: Safe fetal platelet genotyping: new developments. Transfusion 2013; 53: 1755-1762
80. Scheffer PG, Ait Soussan A, Verhagen OJ, et al.: Noninvasive fetal genotyping of human platelet antigen-1a. BJOG 2011; 118: 1392-1395
81. Bertrand G, Bianchi F, Chenet C, et al.: New mutation in the platelet beta3-integrin gene: implication for the diagnosis of fetomaternal alloimmunization. Transfusion 2006; 46: 2138-2141
82. Kjaer KM, Jaegtvik S, Husebekk A, et al.: Human platelet antigen 1 (HPA 1) genotyping with 5' nuclease assay and sequence-specific primers reveals a single nucleotide deletion in intron 2 of the HPA 1a allele of platelet glycoprotein IIIa. Br J Haematol 2002; 117: 405-408
83. Bertrand G, Kaplan C, Kennel A, et al.: New mutation in the beta 3-integrin (GPIIIa) gene inducing HPA-1 genotyping discrepancies. Transfusion 2010; 50: 1589-1591
84. Skogen B, Wang R, McFarland JG, et al.: A dinucleotide deletion in exon 4 of the PlA2 allelic form of glycoprotein IIIa: implications for the correlation of serologic versus genotypic analysis of human platelet alloantigens. Blood 1996; 88: 3831-3836
85. Smith GA, Rankin A, Riddle C, et al.: Severe fetomaternal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-1a in a mother with a rare and silenced ITGB3*0101 (GPIIIa) allele. Vox Sang 2007; 93: 325-330
86. Watkins NA, Schaffner-Reckinger E, Allen DL, et al.: HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope. Blood 2002; 99: 1833-1839
87. Gerald B, Kaplan-Gouet C: Human platelet antigen genotyping and diagnosis of antiplatelet alloimmunization; in Ness PM, Sloan SR, Moulds JM (eds): BeadChip Molecular Immunohematology: Toward Routine Donor and Patient Antigen Profiling by DNA Analysis. New York, Springer, 2011:73-81
88. Avent ND: Large scale blood group genotyping. Transfus Clin Biol 2007; 14: 10-15
89. Avent ND, Martinez A, Flegel WA, et al.: The BloodGen project: toward mass-scale comprehensive genotyping of blood donors in the European Union and beyond. Transfusion 2007; 47: 40S-46S
90. Gassner C, Meyer S, Frey BM, et al.: Matrix-assisted laser desorption/ionisation, time-of-flight mass spectrometry-based blood group genotyping-the alternative approach. Transfus Med Rev 2013; 27: 2-9
91. Kjeldsen-Kragh J, Killie MK, Tomter G, et al.: A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia. Blood 2007; 110: 833-839
92. Killie MK, Kjeldsen-Kragh J, Husebekk A, et al.: Cost-effectiveness of antenatal screening for neonatal alloimmune thrombocytopenia. BJOG 2007; 114: 588-595
93. Tiller H, Killie MK, Chen P, et al.: Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody-mediated immune suppression and prevention of severe clinical complications in a murine model. Transfusion 2012; 52: 1446-1457
94. Ghevaert C, Herbert N, Hawkins L, et al.: Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopenia: proof of principle in human volunteers. Blood 2013; 122: 313-320
95. Killie MK, Husebekk A, Kjeldsen-Kragh J, et al.: A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newborn. Haematologica 2008; 93: 870-877
96. Bessos H, Killie MK, Matviyenko M, et al.: Direct comparison between two quantitative assays in the measurement of maternal anti-HPA-1a antibody in neonatal alloimmune thrombocytopenia (NAIT). Transfus Apher Sci 2008; 39: 221-227
97. Bessos H, Matviyenko M, Brown P, et al.: What's happening-probing of HPA-1a antigen-antibody interaction by surface plasmon resonance technology. Transfus Apher Sci 2008; 39: 179-182
98. Bakchoul T, Bertrand G, Krautwurst A, et al.: The implementation of surface plasmon resonance technique in monitoring pregnancies with expected fetal and neonatal alloimmune thrombocytopenia. Transfusion 2013; 53: 2078-2085
99. Bertrand G, Drame M, Martageix C, et al.: Prediction of the fetal status in noninvasive management of alloimmune thrombocytopenia. Blood 2011; 117: 3209-3213