A point mutation in the EGF-4 domain of β3 integrin is responsible for the formation of the seca platelet alloantigen and affects receptor function

Thrombosis and Haemostasis

Volumn 107, Issue 1, 2012, Pages 80-87

  Sachs, Ulrich J ^a   Bakchoul, Tamam ^a   Eva, Olga ^a   Giptner, Astrid ^a   Bein, Gregor ^a   Aster, Richard H ^b   Gitter, Maria ^b   Peterson, Julie ^b   Santoso, Sentot ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

GP IIb IIIa; HPA; NAIT; Thrombocytopenia

Indexed keywords

ALLOANTIBODY; ALLOANTIGEN; ALPHA2BBETA3 INTEGRIN; ASPARAGINE; BETA3 INTEGRIN; FIBRINOGEN; LYSINE; PROTEIN ANTIBODY; THROMBOCYTE ALLOANTIGEN; UNCLASSIFIED DRUG;

ALLOIMMUNIZATION; ANIMAL CELL; ARTICLE; CASE REPORT; CHO CELL; CONTROLLED STUDY; GENE; GENETIC TRANSFECTION; GENOTYPE; HETEROZYGOSITY; HUMAN; IMMUNOPRECIPITATION; ITGB3 GENE; MALE; MATERNAL SERUM; NEONATAL ALLOIMMUNE THROMBOCYTOPENIA; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PETECHIA; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SEROLOGY; THROMBOCYTE ADHESION; THROMBOCYTE COUNT; WILD TYPE;

ADULT; ANIMALS; ANTIGENS, CD18; BLOOD PLATELETS; CHO CELLS; CRICETINAE; EPIDERMAL GROWTH FACTOR; FEMALE; FETUS; FIBRINOGEN; GENOTYPE; HEMORRHAGE; HETEROZYGOTE; HUMANS; INFANT, NEWBORN; INTEGRIN BETA3; ISOANTIBODIES; ISOANTIGENS; PLATELET ADHESIVENESS; PLATELET MEMBRANE GLYCOPROTEIN IIB; POINT MUTATION; PREGNANCY; PREGNANCY COMPLICATIONS; SEQUENCE ANALYSIS, DNA; TRANSFECTION;

EID: 84855327041     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH11-08-0542     Document Type: Article

References (20)

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