Nausea and the quest for the perfect anti-emetic

European Journal of Pharmacology

Volumn 722, Issue 1, 2014, Pages 108-121

  Andrews, Paul L R ^a   Sanger, Gareth J ^b  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Animal model; Anti emetic; Nausea; Prokinetic; Vasopressin; Vomiting

Indexed keywords

ANTIEMETIC AGENT; APREPITANT; CHLORPROMAZINE; CISPLATIN; DEXAMETHASONE; DOLASETRON MESILATE; DOMPERIDONE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DRONABINOL; DROPERIDOL; FLUPHENAZINE; GABAPENTIN; GHRELIN; GRANISETRON; HALOPERIDOL; MAROPITANT; METOCLOPRAMIDE; NABILONE; NEUROKININ 1 RECEPTOR ANTAGONIST; OLANZAPINE; ONDANSETRON; PALONOSETRON; PROCHLORPERAZINE; PROKINETIC AGENT; RANITIDINE; SEROTONIN 3 ANTAGONIST; SEROTONIN 4 AGONIST; THIETHYLPERAZINE; UNINDEXED DRUG; VASOPRESSIN;

ANESTHESIA; ANIMAL WELFARE; ARTICLE; BRAIN CORTEX; BRAIN REGION; BRAIN STEM; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CHEMOTHERAPY INDUCED NAUSEA AND VOMITING; DISEASE MODEL; DRUG EFFICACY; DRUG TARGETING; ELECTROGASTROGRAPHY; HUMAN; MEDICAL RESEARCH; NAUSEA; NONHUMAN; POSTOPERATIVE NAUSEA AND VOMITING; PREGNANCY; PRIORITY JOURNAL; SEASICKNESS; SELF REPORT; SENSATION; SIGNAL TRANSDUCTION; STOMACH EMPTYING; VASOPRESSIN BLOOD LEVEL;

ANIMAL MODEL; ANTI-EMETIC; NAUSEA; PROKINETIC; VASOPRESSIN; VOMITING;

ANIMALS; ANTIEMETICS; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; HUMANS; NAUSEA; TRANSLATIONAL MEDICAL RESEARCH; VOMITING;

EID: 84892842948     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.09.072     Document Type: Review

References (149)

1. M. Aapro Palonosteron as an anti-emetic and anti-nausea agent in oncology Ther. Clin. Risk Manage. 3 2007 1009 1020
2. P.L.R. Andrews, and P. Bhandari The 5-Hydroxytryptamine receptor antagonists as anti-emetics. Preclinical evaluation and mechanism of action Eur. J. Cancer. 29 A 1993 S11 S16
3. P.L.R. Andrews, and P. Bhandari Resiniferatoxin, an ultrapotent capsaicin analog has antiemetic properties in the ferret Neuropharmacology 32 1993 799 806 (Pubitemid 23227666)
4. P.L.R. Andrews, and C.J. Davis Physiology of emesis induced by anti-cancer chemotherapy J. Reynolds, P.L. Andrews, C.J. Davis, Serotonin and the Scientific Basis of Anti-emetic Therapy 1995 Oxford Clinical Communications Oxford, UK
5. 1 receptor in nausea and emesis P. Holzer, Handbook of Experimental Pharmacology 2004 Springer-Verlag Berlin 359 440
6. P.L.R. Andrews, and G.J. Sanger Treatment of nausea and vomiting: gaps in our knowledge Autonom. Neurosci. 129 2006 3 16 (Pubitemid 44472635)
7. Anon On a peculiar morbid affection of the stomach characterised by regurgitation of its contents without nausea Prov. Med. J. Retrosp. Med. Sci 6 1843 409 413
8. C.C. Apfel, O.S. Cakmakkaya, G. Frings, P. Kranke, A. Malhotra, A. Stader, A. Turan, A. Biedler, and K. Kolodzie Droperidol has comparable clinical efficacy against both nausea and vomiting Br. J. Anesth. 103 2001 359 363
9. M. Araya, M.C. McGoldrick, L.M. Klevay, J.J. Strain, P. Robson, F. Nielsen, M. Olivares, F. Pizarro, L. Johnson, and K.A. Poirer Determination of an acute no-observed-adverse-effect level (NOAEL) for copper in water Regul. Toxicol. Pharmacol. 34 2001 137 145 (Pubitemid 33022325)
10. D.S. Baldwin, T. Hansen, and I. Florea Vortioxetine (Lu AA21004) in the long-tem open label treatment of major depressive disorder Curr. Med. Res. Opin. 28 2012 1217 1724
11. G.R. Barker, G.McL. Cochrane, G.A. Corbett, J.N. Hunt, and S. Kemp Roberts Action of glucose and potassium chloride on osmoreceptors slowing gastric emptying J. Physiol. 237 1974 183 186
12. G.M. Beard The treatment of sea-sickness Br. Med. J. II 1880 362
13. F.W. Beswick Chemical agents used in riot control and warfare Hum. Toxicol 2 1983 247 256 (Pubitemid 13040476)
14. J.R. Bignall, and J. Crofton Antihistamine drugs in te treatment of nausea and vomiting due to streptomycin Br. Med. J. 1 1949 13 14
15. D. Bolognini, E. Rock, N. Cluny, M. Cascio, C. Limebeer, M. Duncan, C. Stott, F. Javid, L. Parker, and R. Pertwee Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT(1A) receptor activation Br. J. Pharmacol. 168 2013 1456 1470
16. H.L. Borison, and L.E. McCarthy Neuropharmacology of chemotherapy-induced emesis Drugs 25 Suppl 1 1981 8 17 (Pubitemid 13195443)
17. H.L. Borison, and S.C. Wang Physiology and pharmacology of vomiting Pharmacol. Rev. 5 1953 193 230
18. D. Borsook, J. Upadhay, M. Klimas, A.J. Schwarz, A. Coimbra, R. Baumgartner, E. George, W.Z. Potter, T. Large, D. Bleakman, J. Eveloch, S. Iyengar, L. Becerra, and R.J. Hargreaves Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain Drug. Discov. Today 17 2012 964 973
19. Box, G.E.P., Draper, N.R., 1987. Empirical model-building and response surfaces. pp424.
20. W.T. Bradner, and J.E. Schurig Toxicology screening in small animals Cancer Treat. Rev. 8 1981 93 102 (Pubitemid 11038464)
21. J. Broad, P.L. Andrews, and G.J. Sanger Vasopressin contracts human isolated stomach muscle: possible role in nausea? Gut 61 2012 A297 A298
22. J. Broad, S. Mukherjee, M. Samadi, J.E. Martin, G.E. Dukes, and G.J. Sanger Regional- and agonist-dependent facilitation of human neurogastrointestinal function by motilin receptor agonists Br. J. Pharmacol. 167 2012 763 774
23. J. Broad, and G.J. Sanger The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin Br. J. Pharmacol. 168 2013 1859 1867
24. H. Burris, P. Hesketh, J. Cohn, W. Moriconi, T. Ryan, C. Friedman, and D. Fitts Efficacy and safety of oral granisetron versus oral prochlorperazine in preventing nausea and emesis in patients receiving moderately emetogenic chemotherapy Cancer J. Sci. Am. 2 1996 85 90
25. F.P. Bymaster, D.O. Calligaro, J.F. Falcone, R.D. Marsh, N.A. Moore, N.C. Tye, P. Seeman, and D.T. Wong Radioreceptor binding profile of the atypical antipsychotic olanzapine Neuropsychopharmacology 14 1996 87 96 (Pubitemid 26053226)
26. P.A. Cabezos, G. Vera, M. Castillo, R. Fernandez-Pujol, M.I. Martin, and R. Abalo Radiological study of gastrointestinal motor activity after acute cisplatin in the rat. Temporal relationship with pica Autonom. Neurosci. 141 2008 54 65
27. 3 antagonist Br. J. Cancer 58 1988 651 653 (Pubitemid 19010720)
28. D.A. Christie, and E.M. Tansey The discovery, use and impact of platinum salts as chemotherapy agents for cancer Wellcome Witness to Twentieth Century Medicine 30 2007 117
29. B.S. Cheung, R.L. Kohl, K.E. Money, and L.B. Kinter Etiologic significance of arginine vasopressin in motion sickness J. Clin. Pharmacol. 34 1994 664 670 (Pubitemid 24187987)
30. T. Chevalier Case of laceration of the internal coat of the stomach and duodenum by vomiting Med. Chir. Trans. 5 1814 93 95
31. R.S.J. Clarke, and J.W. Dundee Side effects of anti-emetics: results of a class experiment Eur. J. Pharmacol. 14 1971 291 300
32. W.M. Court-Brown Symptomatic disturbance after single therapeutic dose of X-rays Br. Med. J. 1 1953 802 804
33. F.M. Cruz, Iracema Gomes Cubero, D. Taranto, P. Lerner, T. Lera, A.T. Costa Miranda, M. Cunha Vieria, M. Sousza Fede, A.B. Schindler, F. Carrasco, M.M. Afonseca, and S.O. Pinczowski, H. Gabpentin for the prevention of chemotherapy-induced nausea and vomiting: a pilot study Support. Care Cancer 20 2012 601 606
34. C.J. Davis, R.K. Harding, R.A. Leslie, and P.L.R. Andrews The organisation of vomiting as a protective reflex: a commentary on the first day's discussions C.J. Davis, G.V. Lake-Bakaar, D.G. Grahame-Smith, Nausea and Vomiting: Mechanisms and Treatment 1986 Springer-Verlag Berlin 65 75
35. 3 antagonists Br. J. Cancer 76 1997 1055 1061 (Pubitemid 27434663)
36. O. Devinsky, M.J. Morrell, and B.A. Vogt Contributions of the anterior cingulate cortex to behaviour Brain 118 1995 279 306
37. L.V. Dos Santos, F.H. Souza, A.T. Brunetto, A.D. Sasse, and da Silva Nogueira Lima, J.P. Neurokinin-1 receptor antagonists for chemotherapy-induced nausea and vomiting: a systematic review J. Natl. Cancer Inst. 104 2012 1280 1292
38. N. Ejskjaer, G. Dimcevski, J. Wo, P.M. Hellström, L.C. Gormsen, I. Sarosiek, E. Softeland, T. Nowak, J.C. Pezzullo, L. Shaugnessy, G. Kosutic, and R. McCallum Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study Neurogastroenterol. Motil. 22 2010 1069 (e281)
39. N. Ejskjaer, J.M. Wo, T. Esfandyari, M. Mazen Jamal, G. Dimcevski, L. Tarnow, R.A. Malik, P.M. Hellström, E. Mondou, J. Quinn, F. Rousseau, and R.W. McCallum A phase 2a, randomized, double-blind 28-day study of TZP-102 a ghrelin receptor agonist for diabetic gastroparesis Neurogastroenterol. Motil. 25 2013 e140 e150
40. R.H. Ellis The Case Books of Dr. John Snow 1994 The Wellcome Trust London, U.K 633
41. J. Foubert, and G. Vaessen Nausea: the neglected symptom? Eur. J. Oncol. Nurs. 9 2005 21 32 (Pubitemid 40361583)
42. M. Fredrikson, T. Hursti, and G. Wik Neural networks in chemotherapy-induced delayed nausea - a pilot-study using positron emission tomography Oncol. Rep. 2 1995 1001 1003
43. Gale, J.D., Houghton, L.A., 2011. Alpha2delta (α2δ) ligands, gabapentin and pregabalin: what is the evidence for potential use of these ligands in irritable bowel syndrome, Article 28, pp. 1-9. www.frontiersin.org (02.06.11).
44. J. Garcia, and W.G. Hankins On the origin of food aversion paradigms L.M. Barker, M.R. Best, M. Domjan, Learning Mechanisms in Food Selection 1977 Baylor University Press Waco, Texas 3 22
45. L.N. Gay, and R.E. Carliner The prevention and treatment of motion sickness. I: seasickness Bull. Johns Hopkins Hosp. 1949 84 470
46. T. Gnecchi Ruscone, S. Guzzetti, F. Lombardi, and R. Lombardi Lack of association between prodromes nausea and vomiting, and specific electrocardiographic patterns of acute myocardial infarction Int. J. Cardiol. 11 1986 17 23 (Pubitemid 16163027)
47. L. Grelot, V. Girod, J. Dapzol, J.P. Maffrand, and C. Serradeil-Le Gal A nonpeptide vasopressin V(1a) receptor antagonist, SR 49059, does not prevent cisplatin-induced emesis in piglets Fundam. Clin. Pharmacol. 15 2001 189 200 (Pubitemid 32868685)
48. T. Guttuso, J. Roscoe, and J. Griggs Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer Lancet 361 2003 1703 1705 (Pubitemid 36577445)
49. A.L. Harris, and B.M.J. Cantwell Mechanism and treatment of cytotoxic-induced nausea and vomiting C.J. Davis, G.V. Lake-Bakaar, D.G. Grahame-Smith., Nausea and Vomiting: Mechanisms and treatment 1986 Springer-Verlag Berlin, Heidelberg p78 93
50. W.L. Hasler, M.S. Kim, W.D. Chey, V. Stevenson, B. Stein, and C. Owyang Central cholinergic and alpha-adrenergic mediation of gastric slow wave dysrhythmias evoked during motion sickness Am. J. Physiol. 268 1995 G539 547
51. R.A. Hatcher The mechanism of vomiting Physiol. Rev. 4 1924 479 504
52. J. Hawthorn, P.L.R. Andrews, V.T.Y. Ang, and J.S. Jenkins Differential release of vasopressin and oxytocin in response to abdominal vagal afferent stimulation of apomorphine in the ferret Brain. Res. 438 1988 193 198 (Pubitemid 18016821)
53. I. Heinzi, J. Sonderegger, and M. Tramer Efficacy, dose-response, and adverse effects of droperidol for prevention of postoperative nausea and vomiting Can. J. Anaesth. 47 2000 537 551
54. Y. Hiura, S. Takiguchi, K. Yamamoto, Y. Kurokawa, M. Yamasaki, K. Nakajima, H. Miyata, Y. Fujiwara, M. Mori, and Y. Doki Fall in plasma ghrelin concentrations after cisplatin-based chemotherapy in esophageal cancer patients Int. J. Clin. Oncol. 17 2012 316 323
55. H.E. Holling Wartime investigations into sea- and airsickness Br. Med. Bull. 5 1947 46 50
56. A.M. Holmes, J.A. Rudd, F.D. Tattersall, Q. Aziz, and P.L.R. Andrews Opportunities for the replacement of animals in the study of nausea and vomiting. replacement in a multi-system reflex Br. J. Pharmacol. 167 2009 865 880
57. C.C. Horn Brain Fos expression induced by the chemotherapy agent cisplatin in the rat is partially dependent on an intact abdominal vagus Autonom. Neurosci. 148 2009 76 82
58. C.C. Horn, E.J. Richardson, P.L.R. Andrews, and M.I. Friedman Differential effects on gastrointestinal and hepatic vagal afferent fibers in the rat by the anti-cancer agent cisplatin Auton. Neurosci 115 2004 74 81 (Pubitemid 39421002)
59. C.C. Horn, S. Henry, K. Meyers, and M.S. Magnusson Behavioural patterns associated with chemotherapy-induced emesis: a potential signature for nausea in musk shrews Front. Neurosci. 2011 5 10.3389/fnins.2011.00088
60. Horn, C.C., Kimball, B.A., Wang, H., Kaus, J., Dienel, S., Nagy, A., Gathright, G.R., Yates, B.J., Andrews, P.L.R., 2013. Why can't rodents vomit? a comparative behavioral, anatomical, and physiological study. 8 (4), e60537. 10.1371/journal.pone.0060537
61. P.J. Hornby Central circuitry associated with emesis Am. Med. J. 111 Suppl. 8A 2001 106S 112S
62. X. Huang, C. Li, Y.L. Luo, B. Wang, and J.L. Ji Efficacy of venlafaxine extended-release monotherapy for first episode depression with painful physical symptoms Neuroreport 24 7 2013 364 369 10.1097/WNR.0b013e3283601a3e
63. 1 receptor agonist induced reflux in rats Neurogastroenterol. Motil. 17 Suppl. 2 2005 S60
64. J.A Irwin The pathology of sea-sickness Lancet 118 1881 907 909
65. B. Isaac, and J.G. MacArthur Influence of chlorpromazine and promethaziane on vomiting induced by apomorphine in man Lancet 267 1954 570 572
66. A.A. Izzo, and K.A. Sharkey Cannabinoids and the gut: new developments and emerging concepts Pharmacol. Ther. 126 2010 21 38
67. M.C. Janselsins, M.A. Tejani, C. Kamen, A.R. Peoples, K.M. Mustian, and G.R. Morrow Current pharmacotherapy for chemotherapy-induced nausea and vomiting in cancer patients Exp. Opin. Pharmacother. 14 2013 757 766
68. 3 receptor antagonist ondansetron on gastric sensorimotor function and nutrient tolerance in healthy volunteers Neurogastroenterol. Motil. 23 2011 444 (e175)
69. F.A. Javid, D.C. Bulmer, J. Broad, Q. Aziz, G.E. Dukes, and G.J. Sanger Anti-emetic and emetic effects of erythromycin in Suncus murinus: potential role of vagal activation, increased gastric motility and motilin receptors Eur. J. Pharmacol. 699 2013 48 54
70. K.D. Johnston The potential for mu-opioid receptor agonists to be anti-emetic in humans: a review of clinical data Acta Anaesthesiol. Scand. 54 2010 132 140
71. R.M. Jokela, O.S. Cakamakkaya, O. Danzeisen, K.T. Korttila, P. Kranke, A. Malhotra, A. Paura, O.C. Radke, D.I. Sessler, A. Soikkeli, P. Roewer, and C.C. Apfel Ondansetron has similar clinical efficacy against both nausea and vomiting Anesthesia 64 2009 147 151
72. J. Kim, V. Napadow, B. Kuo, and R. Barbieri A combined HRV-fMRI approach to assess cortical control of cardiovagal modulation by motion sickness Conf. Proc. IEEE. Eng. Med. Biol. Soc. 2011 2825 2828
73. U. Ladabaum, S.S. Koshy, M.L. Woods, F.G. Hooper, C. Owyang, and W.L. Hasler Differential symptomatic and electrogastrographic effects of distal and proximal human gastric distension Am. J. Physiol. 275 1998 G418 424
74. L.T. La Count, R. Barbieri, K. Park, J. Kim, E.N. Brown, B. Kuo, and V. Napadow Static and dynamic autonomic responses with increasing nausea perception Avait. Space Environ. Med. 82 2011 424 433
75. M. Lee, and M. Feldman Nausea and vomiting M.H. Sleisenger., J.S. Fordtran, Gastrointestinal Disease. Pathophysiology/Diagnosis/Management vol. 1 1993 W.B. Sanders Co. Philadelphia 509 523
76. M.E. Levine, E.R. Muth, M.J. Williamson, and R.M. Stern Protein-predominant meals inhibit the development of gastric tachyarrhythmias, nausea, and the symptoms of motion sickness Aliment. Pharmacol. Ther. 19 2004 583 590 (Pubitemid 38387185)
77. M.E. Levine, M. Gillis, S.Y. Koch, A.C. Voss, R.M. Stern, and K.L. Koch Protein and ginger for the treatment of chemotherapy-induced delayed nausea and gastric dysrhythmia J. Altern. Complement. Med. 14 2008 545 551 (Pubitemid 351873389)
78. 1 agonists are mediated by an action at the visceral insular cortex Br. J. Pharmacol. 167 2012 1126 1136
79. P.A. Lindstrom, and K.R. Brizzee Relief of intractable vomiting from surgical lesions in the area postrema J. Neurosurg. 19 1962 228 236
80. Y.L. Liu, N. Malik, G.J. Sanger, M.I. Friedman, and P.L.R. Andrews Pica - a model of nausea? Species differences in response to cisplatin Physiol. Behav. 85 2005 271 277 (Pubitemid 40840743)
81. J.B. Lucot Pharmacology of motion sickness J. Vestib. Res 18 1998 61 66 (Pubitemid 28078586)
82. F. Marti-Ibanez Philosophical perspectives in motion sickness Int. Record. Med. 167 1954 621 626
83. MASCC, 2004. Multinational Association of Supportive Care in Cancer, Antiemesis Tool: Instructions
84. W.D. Miner, and G.J. Sanger Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism Br. J. Pharmacol. 88 1986 497 499 (Pubitemid 16066912)
85. N. Minton, R. Swift, C. Lawlor, T Mant, and J. Henry Ipecacuanha-induced emesis: a human model for testing antiemetic drug activity Clin. Pharmacol. Ther. 54 1993 53 57 (Pubitemid 23227517)
86. R.B. Moreland, M. Nakane, D.L. Donnelly-Roberts, L.N. Miller, R. Chang, M.E. Uchie, M.A. Terranova, E.J. Gubbins, R.J. Helfrich, M.T. Namovic, O.F. El-Kouhen, J.N. Masters, and J.D. Brioni Comparative pharmacology of human D2-like receptor stable cell lines coupled to calcium flux through Gαqo5 Biochem. Pharmacol. 68 2004 761 772 (Pubitemid 38953458)
87. D.B. Mowrey, and D.E. Clayson Motion sickness, ginger and psychophysics Lancet 1 8273 1982 655 657
88. G.R. Morrow Methodology in behavioral and psychosocial cancer research. The assessment of nausea and vomiting. Past problems, current issues and suggestions for future research Cancer 53 1984 2267 2280 (Pubitemid 14136880)
89. V. Napadow, J.D. Sheehan, L.T. LaCount, K. Park, T.J. Kaptchuk, B.R. Rosen, and B. Kuo The brain circuitry underlying the temporal evolution of nausea in humans Cereb. Cortex 23 2012 806 813
90. Napadow V., Sheehan, J., Kim, J., Dassatti, A., Thurler, A.H., Surjanhata,B., Vangel, M., Makris, N., Schaechter, J.D., Kuo, B., 2013. Brain white matter microstructure is associated with suscetibility to motion-induced nausea. Neurogastroeneterol. Motil. 10.1111/nmo.12084.
91. R.M. Navari, S.E. Gray, and A.C. Kerr Olanzepine versus aprepitant for the prevention of chmeotherapy-induced nausea and vomiting: a randomized phase III trial J. Support. Oncol. 9 2011 188 195
92. K.S. Ng, S.J. Coen, Y.C. Chua, V.F. Ban, M.A. Gresty, G.J. Sanger, S.C. Williams, G.J. Barker, P.L. Andrews, M. Imran, and Q. Aziz Studies of the psychophysiological markers and the brain processing of nausea in healthy humans using a novel virtual reality video Gut 61 2012 A317 318
93. S.S. Nussey, J. Hawthorn, S.R. Page, V.T. Ang, and J.S. Jenkins Responses of plasma oxytocin and arginine vasopressin to nausea induced by apomorphine and ipecacuanha Clin. Endocrinol. (Oxf) 28 297-304 1988
94. C. Oman Are evolutionary hypotheses for motion sickness "just-so" stories? J. Vestib. Res. 22 2012 117 127
95. L.A Parker, and S.W. Kemp Tetrahydrocannabinol (THC) interferes with conditioned retching in Suncus murinus: an animal model of anticipatory nausea and vomiting (ANV) Neuroreport 12 2001 749 751 (Pubitemid 32222711)
96. L.A. Parker, E.M. Rock, and C.L. Limebeer Regulation of nausea and vomiting by cannabinoids Br. J. Pharmacol. 163 2011 1411 1422
97. J. Parkinson, D. Muthas, M. Clark, S. Boyer, J.P. Valentin, and L. Ewart Application of data mining and visualisation techniques for the prediction of drug-induced nausea in man Toxicol. Sci. 126 2012 275 284
98. W. Penfield, and T. Rasumssen The Cerebral Cortex of Man 1950 Macmillan New York, USA
99. N. Percie du Sert, and P.L.R. Andrews The ferret in nausea and vomiting research: lessons in translation of basics science to the clinic J. Fox, R. Marinini, Biology and Diseases of the Ferret 2013 Williams and Wilkins USA (in press)
100. N. Percie du Sert, K.M. Chu, M.K. Wai, J.A. Rudd, and P.L.R. Andrews Reduced normogastric electrical activity associated with emesis: a telemetric study in ferrets World. J. Gastroenterol. 15 2009 6034 6043
101. N. Percie du Sert, J.A. Rudd, R. Moss, and P.L.R. Andrews The delayed phase of cisplatin-induced emesis is mediated by the area postrema and not the abdominal visceral innervation in the ferret Neurosci. Lett. 465 2009 16 20
102. N. Percie du Sert, W.S. Ho, J.A. Rudd, and P.L. Andrews Cannabinoid-induced reduction in antral pacemaker frequency: a telemetric study in the ferret Neurogastroenterol. Motil. 22 2010 1257 1266
103. N. Percie du Sert, K.M. Chu, M.K. Wai, J.A. Rudd, and P.L. Andrews Telemetry in a motion-sickness model implicates the abdominal vagus in motion-induced gastric dysrhythmia Exp. Physiol. 95 2010 768 773
104. 3 receptor antagonists Cancer. Chemother. Pharmacol. 67 2011 667 686
105. N. Percie du Sert, A.M. Holmes, R. Wallis, and P.L. Andrews Predicting the emetic liability of novel chemical entities: a comparative study Br. J. Pharmacol. 165 2012 1848 1867
106. C. Peyrot des Gachons, G.K. Beauchamp, R.M. Stern, K.L. Koch, and P.A.S. Breslin Bitter taste induces nausea Curr. Biol. 21 2011 R247 R248
107. P.M. Plezia, D.S. Alberts, J Kessler, M. Aapro, V. Graham, and E.A. Surwit Immediate termination of intractable vomiting induced by cisplatin combination chemotherapy using an intensive five drug regimen Cancer Treat. Res. 68 1984 1493 1495 (Pubitemid 15187580)
108. A.P. Ray, S. Chebolu, and N.A. Darmani Receptor-selective agonists induce emesis and Fos expression in the brain and enteric nervous system of the least shrew (Cryptotis parva) Pharmacol. Biochem. Behav 94 2009 211 218
109. J.T. Reason, and J.J. Brand Motion Sickness 1975 Academic Press London
110. C.A. Richards, and P.L.R. Andrews Food refusal: a sign of nausea? J. Ped. Gastroenterol. Nutr. 38 2004 227 238
111. S. Robery, J. Mukanowa, N.P. Percie d Sert, P.L.R. Andrews, and R.S.B Williams Investigating the effect of emetic compounds on chemotaxi in Dictyostelium identifies a non-sentient model for bitter and hot tastant research PLoS one 6 2011 e24439
112. M. Rodriguez, M. Lopez, M. Symonds, and G. Hall Lithium-induced context aversion in rats as a model of anticipatory nausea in humans Physiol. Behav. 71 2000 571 579 (Pubitemid 32184783)
113. F. Roila, J. Herstedt, M. Aapo, R.J. Gralla, L.H. Einhorn, E. Ballatori, E. Bria, R.A. Clark-Snow, B.T. Espersen, P. Feyer, S.M. Grunberg, P.J. Hesketh, K. Jordan, M.G. Kris, E. Maranzano, A. Molassiotis, G. Morrow, I. Olver, B.L. Paroport, C. Rittenberg, M. Saito, M. Tonato, and D. Warr Guideline update for MASCC and ESMO in the prevention of chemotherapy-and radiotherapy-induced nausea and vomiting: results of the Perugia consensus conference Annal. Oncol. 21 Suppl. 5 2010 S232 S243
114. C. Rojas, A.G. Thomas, J. Alt, M. Stathis, J. Zhang, E.B. Rubenstein, S. Sebastiani, S. Cantorgeggi, and B.S. Slusher Palonosteron triggers 5-HT3 receptor internalization and causes prolonged inhibition of receptor function Eur. J. Pharmacol. 626 2010 193 199
115. 3 receptor antagonist palonosteron inhibits substance P mediated responses in vitro and in vivo J. Pharmacol. Exp. Ther. 335 2010 362 368
116. J.A. Rudd, and P.L.R. Andrews Mechanisms of acute and delayed nausea and vomiting induced by anticancer therapies P. Hesketh, Management of Nausea and Vomiting in Cancer and Cancer Treatment 2005 Jones and Bartlett Sudbury, Massachusetts 15 66
117. J.A. Rudd, M.P. Ngan, M.K. Wai, A.G. King, J. Witherington, P.L.R. Andrews, and G.J. Sanger Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin Neurosci. Lett. 392 2006 79 83 (Pubitemid 41757580)
118. 4 receptor pharmacology Neurogastroenterol. Motil. 21 2009 1235 1238
119. G.J. Sanger, and P.L.R. Andrews Emesis M.J.G. Farthing, A.B. Ballinger, Drug Therapy for Gastrointestinal and Liver Disease 2001 Martin Dunitz Ltd. London 45 61
120. G.J. Sanger, and P.L.R. Andrews Treatment of nausea and vomiting: gaps in our knowledge Auton. Neurosci 129 2006 3 16 (Pubitemid 44472635)
121. G.J. Sanger, J. Broad, and P.L.R. Andrews The relationship between gastric motility and nausea: gastric prokinetic agents as treatments Eur. J. Pharmacol 715 2013 10 14
122. G.J. Sanger, J.D. Holbrook, and P.L.R. Andrews The translational value of rodent gastrointestinal functions: a cautionary tale Trends Pharmacol. Sci. 32 2011 402 409
123. 3 receptors mediate cytotoxic drug and radiation-evoked emesis Br. J. Cancer 56 1987 159 162 (Pubitemid 17155531)
124. G.J. Sanger, S.M. Westaway, A.A. Barnes, D.T. MacPherson, A.I. Muir, E.M. Jarvie, V. Bolton, S. Cellek, E. Näslund, P.M. Hellström, R.A. Borman, W.P. Unsworth, K.L. Matthews, and K. Lee GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility Neurogastroenterol. Motil. 21 2009 657 666
125. H.S. Sedlacek, D.S. Ramsey, J.F. Boucher, J.S. Eagleson, G.A. Conder, and R.G. Clemence Comparative efficacy of maropitant and selected drugs in preventing emesis induced by centrally or peripherally acting emetogens in dogs J. Vet. Pharmacol. Ther. 31 2008 533 537
126. C.W. Sem-Jacobsen Depth-Electrographic Stimulation of the Human Brain and Behaviour 1968 Charles C Thomas Springfield, Illinois
127. F. Skorpen, E.A. Laugsand, P. Klepstad, and S. Kaasa Variable response to opioid treatment: any genetic predictors within sight? Palliat. Med. 22 2008 310 327 (Pubitemid 351895347)
128. M. Soukop A comparison of two dose levels of granisetron in patients receiving high-dose cisplatin Eur. J. Cancer 26 Suppl. 1 1990 S15 S19
129. 3 receptor antagonist GR38032F Cancer Treat. Revs. 14 1987 333 336 (Pubitemid 18065035)
130. R.M. Stern, K.L. Koch, and P.L.R. Andrews Nausea: Mechanisms and Management 2011 Oxford University Press NY, USA 462
131. 3-receptor antagonist with anti-emetic properties Br. J. Clin. Pharmacol. 27 1989 147 157 (Pubitemid 19059476)
132. Stricker, E.M., McCann, M.J., Flanagan, L.M., Verbalis, J.G., 1998. Neurohypophyseal secretion and gastric function: biological correlates of nausea. In: Takagi, H., Oomura, Y., Ito, M., Otsuka, M. (Eds)., Biowarning System in the Brain. University of Tokyo Press, Tokyo.
133. B receptor agonist baclofen on the mu-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects Neuropharmacology 49 2005 1121 1131 (Pubitemid 41608636)
134. 1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets Neuropharmacology 39 2000 652 663 (Pubitemid 30089315)
135. K. Torigoe, K. Nakahara, M. Rahmadi, K. Yoshizawa, H. Horiuchi, S. Hirayama, S. Imai, N. Kuzumaki, T. Itohm, A. Yamashita, K. Sakunaga, M. Yamasaki, H. Nagase, M. Matoba, T. Suzuki, and M. Narita Usefulness of olanzapine as an adjunct to opioid treatment and for the treatment of neuropathic pain Anesthesiology 116 2012 159 169
136. M.R. Tramer, D.J. Reynolds, R.A. Moore, and H.J. McQuay Efficacy, dose response, and safety of ondansetron in prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized placebo -controlled trials Anesthesiology 87 1997 1277 1279
137. P.B. Tremblay, R. Kaiser, O. Sezer, N. Rosler, C. Schlenz, K. Possinger, I. Roots, and J. Brockmoller Variations in the 5-hydroxytryptamine type 3B receptor gene as predicters of the efficacy of antiemetic treatment in cancer patients J. Clin. Oncol. 21 2003 2147 2155 (Pubitemid 46606363)
138. K.J. Tuerke, B.D. Winters, and L.A. Parker Ondansetron interferes with unconditioned lying-on-belly and acquisition of conditioned gaping induced by LiCl as models of nausea-induced behaviour in rats Physiol. Behav. 105 2012 856 860
139. 3 receptor in the posterior and anterior insular cortex J. Neurosci. 32 2012 13709 13717
140. M.D. Van Sickle, L.D. Oland, W. Ho, C.J. Hillard, K. Mackie, J.S. Davison, and K.A. Sharkey Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret Gastroenterology 121 2001 767 774 (Pubitemid 32959386)
141. D. Walsh Deep tissue traumatism from roentgen ray exposure Br. Med. J. 1897 272 273
142. S.C. Wang Emetic and anti-emetic drugs. In Physiological Pharmacology - a comprehensive treatise W.S. Root, F.G Hofmann, The Nervous System-Part B, Central Nervous System Drugs Vol II 1965 Academic Press New York and London p256 328
143. S.C. Wang, and H.L. Borison A new concept of organization of the central emetic mechanism: recent studies on the sites of action of apomorphine, copper sulphate and cardiac glycosides Gastroenterology 22 1952 1 22
144. S. Wolf The relation of gastric function to nausea in man J. Clin. Invest. 22 1943 877 882
145. G.J. Wood, J.W. Shega, B. Lynch, and J.H. Von Roenn Management of intractable nausea and vomiting in patients at the end of life JAMA 298 2007 1196 1207
146. G.M. Wyant A comparative study of eleven anti-emetic drugs in dogs Can. Anasesthesiol. Soc. J. 9 1962 339
147. L.H. Xu, K.L. Koch, J. Summy-Long, R.M. Stern, J.F. Seaton, T.S. Harrison, L.M. Demers, and S. Bingaman Hypothalamic and gastric myoelectrical responses during vection-induced nausea in healthy Chinese subjects Am. J. Physiol. 265 1993 E578 584
148. K. Yamamoto, M. Nakai, K. Nohara, and A. Yamatodani The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential Eur. J. Pharmacol. 554 2007 34 39 (Pubitemid 44820045)
149. K. Yamamoto, K. Asano, N. Matsukowa, M. Imaizumi, and A. Yamatodani Time-course analysis of pica in rats using an automatic feeding monitoring system J. Pharmacol. Toxicol. Methods 63 2010 30 34