A phase II/III, multicenter, safety, efficacy, and pharmacokinetic study of dexmedetomidine in preterm and term neonates

Journal of Pediatrics

Volumn 164, Issue 2, 2014, Pages

  Chrysostomou, Constantinos ^a   Schulman, Scott R ^b   Herrera Castellanos, Mario ^c   Cofer, Benton E ^d   Mitra, Sanjay ^e   Da Rocha, Marcelo Garcia ^f   Wisemandle, Wayne A ^f   Gramlich, Lisa ^g  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b DUKE CHILDREN S HOSPITAL   (United States)

^c Roosevelt Hospital Guatemala   (Guatemala)

^d GREENVILLE HOSPITAL SYSTEM   (United States)

^e WEST VIRGINIA UNIVERSITY HOSPITALS   (United States)

^f Hospira Inc   (United States)

^g LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adverse event; AE; Area under the concentration curve; AUC; Blood pressure; BP; Half life; Heart rate; HR; LD; Loading dose; Maintenance dose; MD; N PASS; Neonatal Pain, Agitation, Sedation Scale; Pharmacokinetic; PK; Plasma clearance

Indexed keywords

DEXMEDETOMIDINE; ALBUMIN; BILIRUBIN; FENTANYL; MIDAZOLAM; MORPHINE;

AGITATION; ARTICLE; ATELECTASIS; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; GESTATIONAL AGE; HUMAN; HYPERTENSION; HYPOALBUMINEMIA; HYPOCALCEMIA; HYPOKALEMIA; HYPOTENSION; INFANT; MAJOR CLINICAL STUDY; NEONATAL PAIN, AGITATION, SEDATION SCALE; NEWBORN; PAIN; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PLASMA CLEARANCE; PLEURA EFFUSION; PREMATURITY; PRIORITY JOURNAL; RESPIRATORY ACIDOSIS; SCORING SYSTEM; SEDATION; VENTILATED PATIENT; ANALGESIA; AREA UNDER THE CURVE; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC HYPOTENSION; DRUG CLEARANCE; ELIMINATION HALF-LIFE; FEMALE; INFUSION SYSTEM; MALE; MULTICENTER STUDY; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NEONATAL PAIN AGITATION SEDATION SCALE; OUTCOME ASSESSMENT; SIDE EFFECT; TERM BIRTH;

ADVERSE EVENT; AE; AREA UNDER THE CONCENTRATION CURVE; AUC; BLOOD PRESSURE; BP; CL(W); HALF-LIFE; HEART RATE; HR; LD; LOADING DOSE; MAINTENANCE DOSE; MD; N-PASS; NEONATAL PAIN, AGITATION, SEDATION SCALE; PHARMACOKINETIC; PK; PLASMA CLEARANCE; T(1/2);

DEXMEDETOMIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLOW-UP STUDIES; GESTATIONAL AGE; HALF-LIFE; HUMANS; HYPNOTICS AND SEDATIVES; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INFUSIONS, INTRAVENOUS; MALE; PAIN MEASUREMENT; PROSPECTIVE STUDIES; RESPIRATION, ARTIFICIAL; TREATMENT OUTCOME;

EID: 84892822970     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2013.10.002     Document Type: Article

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