MiR-214 Promotes the Alcohol-Induced Oxidative Stress via Down-Regulation of Glutathione Reductase and Cytochrome P450 Oxidoreductase in Liver Cells

Alcoholism: Clinical and Experimental Research

Volumn 38, Issue 1, 2014, Pages 68-77

  Dong, Xiaolong ^a   Liu, Hong ^a   Chen, Fangjie ^a   Li, Dejun ^a   Zhao, Yanyan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Alcohol; Cytochrome P450 Oxidoreductase; Glutathione Reductase; MicroRNA 214; Oxidative Stress

Indexed keywords

ALCOHOL; CYTOCHROME P450 REDUCTASE; GLUTATHIONE REDUCTASE; HEPATOMA DERIVED GROWTH FACTOR; MALONALDEHYDE; MICRORNA 214;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STIMULATION; CELL STRAIN HEK293; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVITY; ESSENTIAL GENE; EXPRESSION VECTOR; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPID OXIDATION; LIVER CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPECTROPHOTOMETRY; UPREGULATION; WESTERN BLOTTING;

RATTUS; RATTUS NORVEGICUS;

ALCOHOL; CYTOCHROME P450 OXIDOREDUCTASE; GLUTATHIONE REDUCTASE; MICRORNA-214; OXIDATIVE STRESS;

ANIMALS; CELL LINE, TUMOR; DOWN-REGULATION; ETHANOL; GLUTATHIONE REDUCTASE; HEK293 CELLS; HEPATOCYTES; HUMANS; MALE; MICRORNAS; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 84892818758     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12209     Document Type: Article

References (36)

1. Albano E, Clot P, Morimoto M, Tomasi A, Ingelman-Sundberg M, French SW (1996) Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology 23:155-163.
2. Aleynik SI, Leo MA, Aleynik MK, Lieber CS (1998) Increased circulating products of lipid peroxidation in patients with alcoholic liver disease. Alcohol Clin Exp Res 22:192-196.
3. Bai XY, Ma Y, Ding R, Fu B, Shi S, Chen XM (2011) miR-335 and miR-34a Promote renal senescence by suppressing mitochondrial antioxidative enzymes. J Am Soc Nephrol 22:1252-1261.
4. Bailey SM, Patel VB, Young TA, Asayama K, Cunningham CC (2001) Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcohol Clin Exp Res 25:726-733.
5. Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P, Szabo G (2011) Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor alpha (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem 286:1436-1444.
6. Bala S, Szabo G (2012) MicroRNA signature in alcoholic liver disease. Int J Hepatol 2012:498232.
7. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281-297.
8. Denby L, Ramdas V, McBride MW, Wang J, Robinson H, McClure J, Crawford W, Lu R, Hillyard DZ, Khanin R, Agami R, Dominiczak AF, Sharpe CC, Baker AH (2011) miR-21 and miR-214 are consistently modulated during renal injury in rodent models. Am J Pathol 179:661-672.
9. Derfoul A, Juan AH, Difilippantonio MJ, Palanisamy N, Ried T, Sartorelli V (2011) Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion and accumulation of the Polycomb Ezh2 methyltransferase. Carcinogenesis 32:1607-1614.
10. Di Luzio NR (1964) Prevention of the acute ethanol-induced fatty liver by the simultaneous administration of antioxidants. Life Sci 3:113-118.
11. Dolganiuc A, Petrasek J, Kodys K, Catalano D, Mandrekar P, Velayudham A, Szabo G (2009) MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice. Alcohol Clin Exp Res 33:1704-1710.
12. Duan Q, Wang X, Gong W, Ni L, Chen C, He X, Chen F, Yang L, Wang P, Wang DW (2012) ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancer. PLoS One 7:e31518.
13. Emerson MR, LeVine SM (2000) Heme oxygenase-1 and NADPH cytochrome P450 reductase expression in experimental allergic encephalomyelitis: an expanded view of the stress response. J Neurochem 75:2555-2562.
14. Gao B, Bataller R (2011) Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141:1572-1585.
15. Han D, Hanawa N, Saberi B, Kaplowitz N (2006) Mechanisms of liver injury. III. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol 291:G1-G7.
16. Heyn J, Ledderose C, Hinske LC, Limbeck E, Möhnle P, Lindner HA, Kreth S (2012) Adenosine A2A receptor upregulation in human PMNs is controlled by miRNA-214, miRNA-15, and miRNA-16. Shock 37:156-163.
17. Lee YB, Bantounas I, Lee DY, Phylactou L, Caldwell MA, Uney JB (2009) Twist-1 regulates the miR-199a/214 cluster during development. Nucleic Acids Res 37:123-128.
18. Li LM, Hou DX, Guo YL, Yang JW, Liu Y, Zhang CY, Zen K (2011) Role of microRNA-214-targeting phosphatase and tensin homolog in advanced glycation end product-induced apoptosis delay in monocytes. J Immunol 186:2552-2560.
19. Maes OC, An J, Sarojini H, Wang E (2008) Murine microRNAs implicated in liver functions and aging process. Mech Ageing Dev 129:534-541.
20. Meagher EA, Barry OP, Burke A, Lucey MR, Lawson JA, Rokach J, FitzGerald GA (1999) Alcohol-induced generation of lipid peroxidation products in humans. J Clin Invest 104:805-813.
21. Mishin V, Gray JP, Heck DE, Laskin DL, Laskin JD (2010) Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes. Free Radic Biol Med 48:1485-1491.
22. Oh SI, Kim CI, Chun HJ, Park SC (1998) Chronic ethanol consumption affects glutathione status in rat liver. J Nutr 128:758-763.
23. Peng RQ, Wan HY, Li HF, Liu M, Li X, Tang H (2012) MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7. J Biol Chem 287:14301-14309.
24. Penna E, Orso F, Cimino D, Tenaglia E, Lembo A, Quaglino E, Poliseno L, Haimovic A, Osella-Abate S, De Pittà C, Pinatel E, Stadler MB, Provero P, Bernengo MG, Osman I, Taverna D (2011) microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C. EMBO J 30:1990-2007.
25. Qiang R, Wang F, Shi LY, Liu M, Chen S, Wan HY, Li YX, Li X, Gao SY, Sun BC, Tang H (2011) Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa cells. Int J Biochem Cell Biol 43:632-641.
26. Sangokoya C, Telen MJ, Chi JT (2010) microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. Blood 116:4338-4348.
27. Schlorff EC, Husain K, Somani SM (1999) Dose- and time-dependent effects of ethanol on plasma antioxidant system in rat. Alcohol 17:97-105.
28. Shih TC, Tien YJ, Wen CJ, Yeh TS, Yu MC, Huang CH, Lee YS, Yen TC, Hsieh SY (2012) MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. J Hepatol 57:584-591.
29. Tang Y, Banan A, Forsyth CB, Fields JZ, Lau CK, Zhang LJ, Keshavarzian A (2008) Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. Alcohol Clin Exp Res 32:355-364.
30. Thulasingam S, Massilamany C, Gangaplara A, Dai H, Yarbaeva S, Subramaniam S, Riethoven JJ, Eudy J, Lou M, Reddy J (2011) miR-27b*, an oxidative stress-responsive microRNA modulates nuclear factor-kB pathway in RAW 264.7 cells. Mol Cell Biochem 352:181-188.
31. Unlu S, Tang S, Wang EN, Martinez I, Tang D, Bianchi ME, Zeh HJ III, Lotze MT (2012) Damage associated molecular pattern molecule-induced microRNAs (DAMPmiRs) in human peripheral blood mononuclear cells. PLoS One 7:e38899.
32. Wu D, Cederbaum AI (2009) Oxidative stress and alcoholic liver disease. Semin Liver Dis 29:141-154.
33. Yang H, Kong W, He L, Zhao JJ, O'Donnell JD, Wang J, Wenham RM, Coppola D, Kruk PA, Nicosia SV, Cheng JQ (2008) MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res 68:425-433.
34. Yeligar SM, Machida K, Kalra VK (2010) Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. J Biol Chem 285:35359-35373.
35. Yeligar S, Tsukamoto H, Kalra VK (2009) Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1α and microRNA-199. J Immunol 183:5232-5243.
36. Zangar RC, Davydov DR, Verma S (2004) Mechanisms that regulate production of reactive oxygen species by cytochrome P450. Toxicol Appl Pharmacol 199:316-331.