The viscoelastic properties of the cervical mucus plug

Acta Obstetricia et Gynecologica Scandinavica

Volumn 93, Issue 2, 2014, Pages 201-208

  Bastholm, Sara K ^a   Becher, Naja ^a   Stubbe, Peter R ^b   Chronakis, Ioannis S ^b   Uldbjerg, Niels ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

cervical mucus plug; infection; Pregnancy; preterm delivery; rheology; viscoelasticity

Indexed keywords

ARTICLE; FEMALE; FLOW KINETICS; FLOW MEASUREMENT; FLOWMETER; HUMAN; LABOR; NORMAL HUMAN; OSCILLATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SHEAR STRESS; SOLID; UTERINE CERVIX MUCUS; VISCOELASTICITY; YOUNG MODULUS;

ADULT; ANALYSIS OF VARIANCE; CERVIX MUCUS; CERVIX UTERI; ELASTIC MODULUS; ELASTICITY; FEMALE; HUMANS; LABOR, OBSTETRIC; PREGNANCY; RHEOLOGY;

EID: 84892815184     PISSN: 00016349     EISSN: 16000412     Source Type: Journal    
DOI: 10.1111/aogs.12308     Document Type: Article

References (29)

1. Becher N, Waldorf KA, Hein M, Uldbjerg N,. The cervical mucus plug: structured review of the literature. Acta Obstet Gynecol Scand. 2009; 88: 502-13.
2. Habte HH, de Beer C, Lotz ZE, Tyler MG, Schoeman L, Kahn D, et al. The inhibition of the Human Immunodeficiency Virus type 1 activity by crude and purified human pregnancy plug mucus and mucins in an inhibition assay. Virol J. 2008; 5: 59.
3. Lee DC, Hassan SS, Romero R, Tarca AL, Bhatti G, Gervasi MT, et al. Protein profiling underscores immunological functions of uterine cervical mucus plug in human pregnancy. J Proteomics. 2011; 74: 817-28.
4. Hein M, Valore EV, Helmig RB, Uldbjerg N, Ganz T,. Antimicrobial factors in the cervical mucus plug. Am J Obstet Gynecol. 2002; 187: 137-44.
5. Eggert-Kruse W, Botz I, Pohl S, Rohr G, Strowitzki T,. Antimicrobial activity of human cervical mucus. Hum Reprod. 2000; 15: 778-84.
6. Critchfield AS, Yao G, Jaishankar A, Friedlander RS, Lieleg O, Doyle PS, et al. Cervical mucus properties stratify risk for preterm birth. PLoS One. 2013; 8: e69528.
7. Chantler E, Debruyne E,. Factors regulating the changes in cervical mucus in different hormonal states. Adv Exp Med Biol. 1977; 89: 131-41.
8. Litt M, Wolf DP, Khan MA,. Functional aspects of mucus rheology. Adv Exp Med Biol. 1977; 89: 191-201.
9. Chretien FC, Cohen J, Borg V, Psychoyos A,. Human cervical mucus during the menstrual cycle and pregnancy in normal and pathological conditions. J Reprod Med. 1975; 14: 192-6.
10. Weiss G,. Rheologic method for determining hormonal influence on cervical mucus. Fertil Steril. 1968; 19: 771-7.
11. Wolf DP, Blasco L, Khan MA, Litt M,. Human cervical mucus. II. Changes in viscoelasticity during the ovulatory menstrual cycle. Fertil Steril. 1977; 28: 47-52.
12. Chretien FC, Engelmann P, Dubois R,. The variation of the mean spinability of human cervical mucus throughout the various stages of reproductive life. Automatic measurement and statistical study. Eur J Obstet Gynecol Reprod Biol. 1979; 9: 289-97.
13. Wiggins R, Hicks SJ, Soothill PW, Millar MR, Corfield AP,. Mucinases and sialidases: their role in the pathogenesis of sexually transmitted infections in the female genital tract. Sex Transm Infect. 2001; 77: 402-8.
14. Cone RA,. Barrier properties of mucus. Adv Drug Deliv Rev. 2009; 61: 75-85.
15. Thornton DJ, Sheehan JK,. From mucins to mucus: toward a more coherent understanding of this essential barrier. Proc Am Thorac Soc. 2004; 1: 54-61.
16. Odeblad E,. The functional structure of human cervical mucus. Acta Obstet Gynecol Scand. 1968; 47: 57-79.
17. Carlstedt I, Sheehan JK,. Structure and macromolecular properties of cervical mucus glycoproteins. Symp Soc Exp Biol. 1989; 43: 289-316.
18. Chronakis IS, Piculell L, Borgström J,. Rheology of kappa-carrageenan in mixtures of sodium and cesium iodide: two types of gels. Carbohydr Polym. 1996; 31: 215-25.
19. Steffe JF,. Rheological methods in food process engineering, 2nd edn. East Lansing MI: Freeman Press, 1996.
20. Wolf DP, Blasco L, Khan MA, Litt M,. Human cervical mucus. I. Rheologic characteristics. Fertil Steril. 1977; 28: 41-6.
21. Tomasetto C, Masson R, Linares JL, Wendling C, Lefebvre O, Chenard MP, et al. pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. Gastroenterology. 2000; 118: 70-80.
22. Ruchaud-Sparagano MH, Westley BR, May FE,. The trefoil protein TFF1 is bound to MUC5AC in human gastric mucosa. Cell Mol Life Sci. 2004; 61: 1946-54.
23. Thim L, Madsen F, Poulsen SS,. Effect of trefoil factors on the viscoelastic properties of mucus gels. Eur J Clin Invest. 2002; 32: 519-27.
24. Kindon H, Pothoulakis C, Thim L, Lynch-Devaney K, Podolsky DK,. Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein. Gastroenterology. 1995; 109: 516-23.
25. Brunelli R, Papi M, Arcovito G, Bompiani A, Castagnola M, Parasassi T, et al. Globular structure of human ovulatory cervical mucus. FASEB J. 2007; 21: 3872-6.
26. Hein M, Petersen AC, Helmig RB, Uldbjerg N, Reinholdt J,. Immunoglobulin levels and phagocytes in the cervical mucus plug at term of pregnancy. Acta Obstet Gynecol Scand. 2005; 84: 734-42.
27. Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel L, Hassan S,. The role of inflammation and infection in preterm birth. Semin Reprod Med. 2007; 25: 21-39.
28. Olmsted SS, Padgett JL, Yudin AI, Whaley KJ, Moench TR, Cone RA,. Diffusion of macromolecules and virus-like particles in human cervical mucus. Biophys J. 2001; 81: 1930-7.
29. Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, et al. The preterm parturition syndrome. BJOG. 2006; 113 (Suppl 3): 17-42.