Serrated lesions of the appendix frequently harbor KRAS mutations and not BRAF mutations indicating a distinctly different serrated neoplastic pathway in the appendix

Human Pathology

Volumn 45, Issue 2, 2014, Pages 227-235

  Hartman, Douglas J ^b   Gonzalo, David H ^a   Lai, Keith K ^a   Downs Kelly, Erinn ^a   Goldblum, John R ^a   Liu, Xiuli ^a   Patil, Deepa T ^a   Bennett, Ana E ^a   Plesec, Thomas P ^a   Kuan, Shih Fan ^b   Nikiforova, Marina N ^b   Shadrach, Bonnie ^a   Pai, Reetesh K ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Appendix; BRAF; Hyperplastic polyp; KRAS; Serrated polyp; Sessile serrated adenoma

Indexed keywords

B RAF KINASE; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE;

APPENDIX DISEASE; APPENDIX TUMOR; ARTICLE; CLINICAL FEATURE; COLORECTAL POLYP; CONTROLLED STUDY; CYTOLOGY; FEMALE; GASTROINTESTINAL DYSPLASIA; GENE FREQUENCY; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; RECTUM ADENOMA; TUMOR DIFFERENTIATION;

APPENDIX; BRAF; HYPERPLASTIC POLYP; KRAS; SERRATED POLYP; SESSILE SERRATED ADENOMA;

APPENDICEAL NEOPLASMS; APPENDIX; HUMANS; INTESTINAL POLYPS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS;

EID: 84892730940     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.10.021     Document Type: Article

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