DNA damage in lens epithelial cells and peripheral lymphocytes from age-related cataract patients

Ophthalmic Research

Volumn 51, Issue 3, 2014, Pages 124-128

  Zhang, Junfang ^a   Wu, Jian ^a   Yang, Ling ^a   Zhu, Rongrong ^a   Yang, Mei ^a   Qin, Bai ^a   Shi, Haihong ^a   Guan, Huaijin ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Age related cataract; Comet assay; DNA damage; Lens epithelial cells; Lymphocytes

Indexed keywords

DNA;

ADULT; AGED; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; EPITHELIUM CELL; FEMALE; HUMAN; LENS EPITHELIAL CELL; LENS EPITHELIUM; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RETINA DETACHMENT; SENILE CATARACT; SUBCAPSULAR CATARACT; HUMAN CELL; LENS EPITHELIUM CELL; OXIDATIVE STRESS; PATHOGENESIS;

AGED; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CATARACT; COMET ASSAY; DNA DAMAGE; EPITHELIAL CELLS; FEMALE; HUMANS; LENS, CRYSTALLINE; LYMPHOCYTES; MALE; MIDDLE AGED; OXIDATIVE STRESS;

EID: 84892712424     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000356399     Document Type: Article

References (31)

1. Beebe DC, Holekamp NM, Shui YB: Oxidative damage and the prevention of age-related cataracts. Ophthalmic Res 2010; 44: 155-165.
2. Frick KD, Foster A: The magnitude and cost of global blindness: an increasing problem that can be alleviated. Am J Ophthalmol 2003; 135: 471-476.
3. Sorte K, Sune P, Bhake A, Shivkumar VB, Gangane N, Basak A: Quantitative assessment of DNA damage directly in lens epithelial cells from senile cataract patients. Mol Vis 2011; 17: 1-6.
4. Chang D, Zhang X, Rong S, Sha Q, Liu P, Han T, Pan H: Serum antioxidative enzymes levels and oxidative stress products in age-related cataract patients. Oxid Med Cell Longev 2013; 2013: 587826.
5. Ates O, Alp HH, Kocer I, Baykal O, Salman IA: Oxidative DNA damage in patients with cataract. Acta Ophthalmol 2010; 88: 891-895.
6. Kaur J, Kukreja S, Kaur A, Malhotra N, Kaur R: The oxidative stress in cataract patients. J Clin Diagn Res 2012; 6: 1629-1632.
7. Zhang Y, Zhang L, Sun D, Li Z, Wang L, Liu P: Genetic polymorphisms of superoxide dismutases, catalase, and glutathione peroxidase in age-related cataract. Mol Vis 2011; 17: 2325-2332.
8. Celojevic D, Nilsson S, Behndig A, Tasa G, Juronen E, Karlsson JO, Zetterberg H, Petersen A, Zetterberg M: Superoxide dismutase gene polymorphisms in patients with age-related cataract. Ophthalmic Genet 2013; 34: 140-145.
9. Zhang Y, Zhang L, Song Z, Sun DL, Liu HR, Fu SB, Liu DR, Liu P: Genetic polymorphisms in DNA repair genes OGG1, APE1, XRCC1, and XPD and the risk of age-related cataract. Ophthalmology 2012; 119: 900-906.
10. Luo YF, Wang BB, Zhou Z, Ding XC, Hu SS, Zhou GK, Ma X, Qi YH: Polymorphisms of the DNA repair genes XPD and XRCC1 and the risk of age-related cataract development in Han Chinese. Curr Eye Res 2011; 36: 632-636.
11. Su S, Yao Y, Zhu R, Liang C, Jiang S, Hu N, Zhou J, Yang M, Xing Q, Guan H: The associations between single nucleotide polymorphisms of DNA repair genes, DNA damage, and age-related cataract: Jiangsu Eye Study. Invest Ophthalmol Vis Sci 2013; 54: 1201-1207.
12. Bannik K, Rossler U, Faus-Kessler T, Gomolka M, Hornhardt S, Dalke C, Klymenko O, Rosemann M, Trott KR, Atkinson M, Kulka U, Graw J: Are mouse lens epithelial cells more sensitive to gamma-irradiation than lymphocytes? Radiat Environ Biophys 2013; 52: 279-286.
13. Jiang S, Hu N, Zhou J, Zhang J, Gao R, Hu J, Guan H: Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese Population. Age (Dordr) 2013; 35: 2435-2444.
14. Jiang J, Zhou J, Yao Y, Zhu R, Liang C, Jiang S, Yang M, Lu Y, Xing Q, Guan H: Copy number variations of DNA repair genes and the age-related cataract: Jiangsu Eye Study. Invest Ophthalmol Vis Sci 2013; 54: 932-938.
15. Pendergrass W, Zitnik G, Tsai R, Wolf N: Xray induced cataract is preceded by LEC loss, and coincident with accumulation of cortical DNA, and ROS; similarities with age-related cataracts. Mol Vis 2010; 16: 1496-1513.
16. Zhang Y, Zhang L, Bai J, Ge H, Liu P: Expression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens. Mol Vis 2010; 16: 1754-1763.
17. Kisic B, Miric D, Zoric L, Ilic A, Dragojevic I: Antioxidant capacity of lenses with age-related cataract. Oxid Med Cell Longev 2012; 2012: 467130.
18. Zoric L: Parameters of oxidative stress in the lens, aqueous humor and blood in patients with diabetes and senile cataracts (in Serbian). Srp Arh Celok Lek 2003; 131: 137-142.
19. Wang X, Simpkins JW, Dykens JA, Cammarata PR: Oxidative damage to human lens epithelial cells in culture: estrogen protection of mitochondrial potential, ATP, and cell viability. Invest Ophthalmol Vis Sci 2003; 44: 2067-2075.
20. Osnes-Ringen O, Azqueta AO, Moe MC, Zetterstrom C, Roger M, Nicolaissen B, Collins AR: DNA damage in lens epithelium of cataract patients in vivo and ex vivo. Acta Ophthalmol 2013; 91: 652-656.
21. Kleiman NJ, Spector A: DNA single strand breaks in human lens epithelial cells from patients with cataract. Curr Eye Res 1993; 12: 423-431.
22. Kumaravel TS, Vilhar B, Faux SP, Jha AN: Comet assay measurements: a perspective. Cell Biol Toxicol 2009; 25: 53-64.
23. Cortes-Gutierrez EI, Hernandez-Garza F, Garcia-Perez JO, Davila-Rodriguez MI, Aguado-Barrera ME, Cerda-Flores RM: Evaluation of DNA single and double strand breaks in women with cervical neoplasia based on alkaline and neutral comet assay techniques. J Biomed Biotechnol 2012; 2012: 385245.
24. Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, Mc- Carthy D, Wu SY: The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group. Arch Ophthalmol 1993; 111: 831-836.
25. Wu C, Lin H, Wang Q, Chen W, Luo H, Zhang H: Discrepant expression of microRNAs in transparent and cataractous human lenses. Invest Ophthalmol Vis Sci 2012; 53: 3906-3912.
26. Singh NP, McCoy MT, Tice RR, Schneider EL: A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988; 175: 184-191.
27. Watters JL, Satia JA, da Costa KA, Boysen G, Collins LB, Morrow JD, Milne GL, Swenberg JA: Comparison of three oxidative stress biomarkers in a sample of healthy adults. Biomarkers 2009; 14: 587-595.
28. Rajkumar S, Praveen MR, Gajjar D, Vasavada AR, Alapure B, Patel D, Kapur S: Activity of superoxide dismutase isoenzymes in lens epithelial cells derived from different types of age-related cataract. J Cataract Refract Surg 2008; 34: 470-474.
29. Cekic S, Zlatanovic G, Cvetkovic T, Petrovic B: Oxidative stress in cataractogenesis. Bosn J Basic Med Sci 2010; 10: 265-269.
30. Singh NP, Penn PE, Pendergrass WR, Wolf NS: White light-mediated DNA strand breaks in lens epithelial cells. Exp Eye Res 2002; 75: 555-560.
31. Sorkhabi R, Ghorbanihaghjo A, Javadzadeh A, Rashtchizadeh N, Moharrery M: Oxidative DNA damage and total antioxidant status in glaucoma patients. Mol Vis 2011; 17: 41-46.