Acute osteomyelitis in children

New England Journal of Medicine

Volumn 370, Issue 4, 2014, Pages 352-360

  Peltola, Heikki ^a   Paä̈kk̈onen, Markus ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; C REACTIVE PROTEIN; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; CHLORAMPHENICOL; CLINDAMYCIN; LINEZOLID; PENICILLIN DERIVATIVE; PROCALCITONIN; VANCOMYCIN;

ACUTE OSTEOMYELITIS; ANTIBIOTIC THERAPY; ARM FRACTURE; BONE RADIOGRAPHY; BONE SCINTISCANNING; CALLUS; CHILD; CHILDHOOD DISEASE; CLINICAL FEATURE; ERYTHROCYTE SEDIMENTATION RATE; HUMAN; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; NONHUMAN; ORTHOPEDIC SURGERY; OSTEOMYELITIS; OUTCOME ASSESSMENT; PATHOLOGIC FRACTURE; PERSONALIZED MEDICINE; PHYSICAL EXAMINATION; PRIORITY JOURNAL; REVIEW; TREATMENT DURATION; TREATMENT RESPONSE;

EID: 84892694883     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMra1213956     Document Type: Review

References (50)

1. Krogstad P. Osteomyelitis. In: Feigin RD, Cherry JD, Demmler-Harrison GJ, Kaplan SL, eds. Pediatric infectious diseases. 6th ed. Philadelphia: Saunders, 2009:725-42.
2. Riise ØR, Kirkhus E, Handeland KS, et al. Childhood osteomyelitis-incidence and differentiation from other acute onset musculoskeletal features in a population-based study. BMC Pediatr 2008;8:45.
3. Grammatico-Guillon L, Maakaroun Vermesse Z, Baron S, Gettner S, Rusch E, Bernard L. Paediatric bone and joint infections are more common in boys and toddlers: a national epidemiology study. Acta Paediatr 2013;102(3):e120-e125.
4. Gillespie WJ, Mayo KM. The management of acute haematogenous osteomyelitis in the antibiotic era: a study of the outcome. J Bone Joint Surg Br 1981;63-B:126-31.
5. Syrogiannopoulos GA, Nelson JD. Duration of antimicrobial therapy for acute suppurative osteoarticular infections. Lancet 1988;1:37-40.
6. Jaberi FM, Shahcheraghi GH, Ahadzadeh M. Short-term intravenous antibiotic treatment of acute hematogenous bone and joint infection in children: a prospective randomized trial. J Pediatr Orthop 2002;22:317-20.
7. Prado SMA, Lizama CM, Peña DA, Valenzuela MC, Viviani ST. Short duration of initial intravenous treatment in 70 pediatric patients with osteoarticular infections. Rev Chilena Infectol 2008;25:30-6. (In Spanish.)
8. Jagodzinski NA, Kanwar R, Graham K, Bache CE. Prospective evaluation of a shortened regimen of treatment for acute osteomyelitis and septic arthritis in children. J Pediatr Orthop 2009;29:518-25.
9. Peltola H, Pääkkönen M, Kallio P, Kallio MJ. Short- versus long-term antimicrobial treatment for acute hematogenous osteomyelitis of childhood: prospective, randomized trial on 131 culture-positive cases. Pediatr Infect Dis J 2010;29:1123-8.
10. Atkins BL, Price EH, Tillyer L, Novelli V, Evans J. Salmonella osteomyelitis in sickle cell disease children in the east end of London. J Infect 1997;34:133-8.
11. Yagupsky P, Porsch E, St Geme JW III. Kingella kingae: an emerging pathogen in young children. Pediatrics 2011;127:557-65.
12. Dartnell J, Ramachandran M, Katchburian M. Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature. J Bone Joint Surg Br 2012;94:584-95.
13. Ju KL, Zurakowski D, Kocher MS. Differentiating between methicillin-resistant and methicillin-sensitive Staphylococcus aureus osteomyelitis in children: an evidencebased clinical prediction algorithm. J Bone Joint Surg Am 2011;93:1693-701.
14. Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin- resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis 2011;52(3):e18-e55. [Erratum, Clin Infect Dis 2011;53:319.]
15. Butbul-Aviel Y, Koren A, Halevy R, Sakran W. Procalcitonin as a diagnostic aid in osteomyelitis and septic arthritis. Pediatr Emerg Care 2005;21:828-32.
16. Pääkkönen M, Kallio MJ, Kallio PE, Peltola H. Sensitivity of erythrocyte sedimentation rate and C-reactive protein in childhood bone and joint infections. Clin Orthop Relat Res 2010;468:861-6.
17. Arnold JC, Cannavino CR, Ross MK, et al. Acute bacterial osteoarticular infections: eight-year analysis of C-reactive protein for oral step-down therapy. Pediatrics 2012;130(4):e821-e828.
18. Ceroni D, Regusci M, Pazos J, Dayer R, Kaelin A. Acute bone and joint infections in children: how much attention should be paid to persistent fever during intravenous antibiotic therapy? Rev Chir Orthop Reparatrice Appar Mot 2003;89: 250-6. (In French.)
19. Connolly LP, Connolly SA, Drubach LA, Jaramillo D, Treves ST. Acute hematogenous osteomyelitis of children: assessment of skeletal scintigraphy-based diagnosis in the era of MRI. J Nucl Med 2002; 43:1310-6.
20. Peltola H, Pääkkönen M, Kallio P, Kallio MJT. Clindamycin vs. first-generation cephalosporins for acute osteoarticular infections of childhood - a prospective quasi-randomized controlled trial. Clin Microbiol Infect 2012;18:582-9.
21. Tetzlaff TR, Howard JB, McCraken GH, Calderon E, Larrondo J. Antibiotic concentrations in pus and bone of children with osteomyelitis. J Pediatr 1978;92: 135-40.
22. Feigin RD, Pickering LK, Anderson D, Keeney RE, Shackleford PG. Clindamycin treatment of osteomyelitis and septic arthritis in children. Pediatrics 1975;55:213-23.
23. Landersdorfer CB, Bulitta JB, Kinzig M, Holzgrabe U, Sörgel F. Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations. Clin Pharmacokinet 2009;48: 89-124.
24. Kaplan SL, Afghani B, Lopez P, et al. Linezolid for the treatment of methicillin-resistant Staphylococcus aureus infection in children. Pediatr Infect Dis J 2003;22: Suppl:S178-S185.
25. Chen CJ, Chiu CH, Lin TY, Lee ZL, Yang WE, Huang YC. Experience with linezolid therapy in children with osteoarticular infections. Pediatr Infect Dis J 2007;26:985-8.
26. Summersgill JT, Schupp LG, Raff MJ. Comparative penetration of metronidazole, clindamycin, chloramphenicol, cefoxitin, ticarcillin, and moxalactam into bone. Antimicrob Agents Chemother 1982;21:601-3.
27. Tetzlaff TR, McCracken GH Jr, Nelson JD. Oral antibiotic therapy for skeletal infections of children. II. Therapy of osteomyelitis and suppurative arthritis. J Pediatr 1978;92:485-90.
28. Green JH. Cloxacillin in treatment of acute osteomyelitis. Br Med J 1967;2:414-6.
29. Kaplan SL, Mason EO Jr, Feigin RD. Clindamycin versus nafcillin or methicillin in the treatment of Staphylococcus aureus osteomyelitis in children. South Med J 1982;75:138-42.
30. Martínez-Aguilar G, Hammerman WA, Mason EO Jr, Kaplan SL. Clindamycin treatment of invasive infections caused by community-acquired, methicillin-resistant and methicillin-susceptible Staphylococcus aureus in children. Pediatr Infect Dis J 2003;22:593-8.
31. Dubnov-Raz G, Scheuerman O, Chodick G, Finkelstein Y, Samra Z, Garty BZ. Invasive Kingella kingae infections in children: clinical and laboratory characteristics. Pediatrics 2008;122:1305-9.
32. Messina AF, Namtu K, Guild M, Dumois JA, Berman DM. Trimethoprim- sulfamethoxazole therapy for children with acute osteomyelitis. Pediatr Infect Dis J 2011;30:1019-21.
33. Sherman JW, Conte JE Jr. Ceftriaxone treatment of multidrug-resistant Salmonella osteomyelitis. Am J Med 1987;83: 137-8.
34. Bradley JS, Jackson MA, Committee on Infectious Diseases, American Academy of Pediatrics. The use of systemic and topical fluoroquinolones. Pediatrics 2011; 128(4):e1034-e1045.
35. Ebong WW. Acute osteomyelitis in Nigerians with sickle cell disease. Ann Rheum Dis 1986;45:911-5.
36. Mantadakis E, Plessa E, Vouloumanou EK, Michailidis L, Chatzimichael A, Falagas ME. Deep venous thrombosis in children with musculoskeletal infections: the clinical evidence. Int J Infect Dis 2012; 16(4):e236-e243.
37. Dich VQ, Nelson JD, Haltalin KC. Osteomyelitis in infants and children: a review of 163 cases. Am J Dis Child 1975; 129:1273-8.
38. Vaughan PA, Newman NM, Rosman MA. Acute hematogenous osteomyelitis in children. J Pediatr Orthop 1987;7:652-5.
39. Penberthy GC, Weller CN. Chemotherapy as an aid in the management of acute osteomyelitis. Ann Surg 1941;114: 129-46.
40. Kenney WE. The prognosis in acute haematogenous osteomyelitis with and without chemotherapy. Surgery 1944;16: 477-84.
41. Harris NH. Some problems in the diagnosis and treatment of acute osteomyelitis. J Bone Joint Surg Br 1960;42-B:535-41.
42. Cole WG, Dalziel RE, Leitl S. Treatment of acute osteomyelitis in childhood. J Bone Joint Surg Br 1982;64:218-23.
43. Bocchini CE, Hulten KG, Mason EO Jr, Gonzalez BE, Hammerman WA, Kaplan SL. Panton-Valentine leukocidin genes are associated with enhanced inflammatory response and local disease in acute hematogenous Staphylococcus aureus osteomyelitis in children. Pediatrics 2006;117:433-40.
44. Belthur MV, Birchansky SB, Verdugo AA, et al. Pathologic fractures in children with acute Staphylococcus aureus osteomyelitis. J Bone Joint Surg Am 2012;94:34-42.
45. Bradley JS, Kaplan SL, Tan TQ, et al. Pediatric pneumococcal bone and joint infections. Pediatrics 1998;102:1376-82.
46. Martí-Carvajal AJ, Agreda-Pérez LH. Antibiotics for treating osteomyelitis in people with sickle cell disease. Cochrane Database Syst Rev 2012;12:CD007175.
47. Meller I, Manor Y, Bar-Ziv J, Torok G. Acute hematogenous osteomyelitis in children: long-term results of surgical treatment. Orthop Rev 1989;18:824-31.
48. Connolly SA, Connolly LP, Drubach LA, Zurakowski D, Jaramillo D. MRI for detection of abscess in acute osteomyelitis of the pelvis in children. AJR Am J Roentgenol 2007;189:867-72.
49. Vander Have KL, Karmazyn B, Verma M, et al. Community-associated methicillin-resistant Staphylococcus aureus in acute musculoskeletal infection in children: a game changer. J Pediatr Orthop 2009;29: 927-31.
50. Stephens MM, MacAuley P. Brodie's abscess: a long-term review. Clin Orthop Relat Res 1988;234:211-6.