Kingella kingae: An emerging pathogen in young children

Pediatrics

Volumn 127, Issue 3, 2011, Pages 557-565

  Yagupsky, Pablo ^a   Porsch, Eric ^b   St Geme III, Joseph W ^b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Carriage; Children; Daycare centers; Invasive disease; Kingella kingae; Pathogenesis

Indexed keywords

BETA LACTAM;

AGE; BACTEREMIA; CLINICAL ASSESSMENT; CULTURAL ANTHROPOLOGY; DAY CARE; ENDOCARDITIS; KINGELLA KINGAE; NONHUMAN; NUCLEIC ACID AMPLIFICATION; PHARYNX; PRIORITY JOURNAL; REVIEW; VIRULENCE;

CHILD; CHILD DAY CARE CENTERS; HUMANS; INCIDENCE; KINGELLA KINGAE; NEISSERIACEAE INFECTIONS; UNITED STATES;

EID: 79952211806     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2010-1867     Document Type: Review

References (61)

1. Yagupsky P, Dagan R, Howard CW, Einhorn M, Kassis I, Simu A. High prevalence of Kingella kingae in joint fluid from children with septic arthritis revealed by the BACTEC blood culture system. J Clin Microbiol. 1992;30(5):1278-1281
2. Moylett EH, Rossmann SN, Epps HR, Demmler GJ. Importance of Kingella kingae as a pediatric pathogen in the United States. Pediatr Infect Dis J. 2000;19(3):263-265
3. Moumile K, Merckx J, Glorion C, Pouliquen JC, Berche P, Ferroni A. Bacterial aetiology of acute osteoarticular infections in children. Acta Paediatr. 2005;94(4):419-422
4. Dubnov-Raz G, Scheuerman O, Chodick G, Finkelstein Y, Samra Z, Garty BZ. Invasive Kingella kingae infections in children: clinical and laboratory characteristics. Pediatrics. 2008;122(6):1305-1309
5. Verdier I, Gayet-Ageron A, Ploton C, et al. Contribution of a broad range polymerase chain reaction to the diagnosis of osteoarticular infections caused by Kingella kingae: description of twenty-four recent pediatric diagnoses. Pediatr Infect Dis J. 2005;24(8):692-696
6. Chometon S, Benito Y, Chaker M, et al. Specific real-time polymerase chain reaction places Kingella kingae as the most common cause of osteoarticular infections in young children. Pediatr Infect Dis J. 2007;26(5):377-381
7. Ilharreborde B, Bidet P, Lorrot M, et al. A new real-time PCR-based method for Kingella kingae DNA detection: application to a prospective series of 89 children with acute arthritis. J Clin Microbiol. 2009;47(6):1837-1841
8. Yagupsky P, Dagan R. Kingella kingae bacteremia in children. Pediatr Infect Dis J. 1994;13(12):1148-1149
9. Yagupsky P, Bar-Ziv Y, Howard CB, Dagan R. Epidemiology, etiology, and clinical features of septic arthritis in children younger than 24 months. Arch Pediatr Adolesc Med. 1995;149(5):537-540
10. Von Graevenitz A, Zbinden R, Mutters R. Actinobacillus, Capnocytophaga, Eikenella, Kingella, Pasteurella, and other fastidious or rarely encountered gram-negative rods. In: Murray PR, Baron EJ, Jorgensen JH, Pfaller MA, Yolken RH, eds. Manual of Clinical Microbiology. 8th ed. Washington, DC: American Society for Microbiology; 2003:614-615
11. Yagupsky P. Kingella kingae: from medical rarity to an emerging paediatric pathogen. Lancet Infect Dis. 2004;4(6):358-367
12. Yagupsky P, Dagan R, Prajgrod F, Merires M. Respiratory carriage of Kingella kingae among healthy children. Pediatr Infect Dis J. 1995;14(8):673-678
13. Yagupsky P, Weiss-Salz I, Fluss R, et al. Dissemination of Kingella kingae in the community and long-term persistence of invasive clones. Pediatr Infect Dis J. 2009;28(8):707-710
14. Yagupsky P, Peled N, Katz O. Epidemiological features of invasive Kingella kingae infections and respiratory carriage of the organism. J Clin Microbiol. 2002;40(11):4180-4184
15. Yagupsky P, Porat N, Pinco E. Pharyngeal colonization by Kingella kingae in children with invasive disease. Pediatr Infect Dis J. 2009;28(2):155-157
16. Dubnov-Raz G, Ephros M, Garty BZ, et al. Invasive pediatric Kingella kingae infections: a nationwide collaborative study. Pediatr Infect Dis J. 2010;29(7):639-643
17. Van Erps J, Schmedding E, Naessens A, Keymeulen B. Kingella kingae, a rare cause of bacterial meningitis. Clin Neurol Neurosurg. 1992;94(2):173-175
18. Carden SM, Colville DJ, Gonis G, Gilbert GL. Kingella kingae endophtalmitis in an infant. Aust N Z J Ophthalmol. 1991;19(3):217-220
19. Bofinger JJ, Fekete T, Samuel R. Bacterial peritonitis caused by Kingella kingae. J Clin Microbiol. 2007;45(9):3118-3120
20. Matta M, Wermert D, Podglajen I, et al. Molecular diagnosis of Kingella kingae pericarditis by amplification and sequencing of the 16S rRNA gene. J Clin Microbiol. 2007;45(9):3133-3134
21. Slonim A, Walker ES, Mishori E, Porat N, Dagan R, Yagupsky P. Person-to-person transmission of Kingella kingae among day care center attendees. J Infect Dis. 1998;178(6):1843-1846
22. Yagupsky P, Erlich Y, Ariela S, Trefler R, Porat N. Outbreak of Kingella kingae skeletal system infections in children in daycare. Pediatr Infect Dis J. 2006;25(6):526-532
23. Kiang KM, Ogunmodede F, Juni BA, et al. Outbreak of osteomyelitis/septic arthritis caused by Kingella kingae among child care center attendees. Pediatrics. 2005;116(2). Available at: www.pediatrics.org/cgi/content/full/116/ 2/e206
24. Seña AC, Seed P, Nicholson B, Joyce M, Cunningham CK. Kingella kingae endocarditis and a cluster investigation among daycare attendees. Pediatr Infect Dis J. 2010;29(1):86-88
25. Slonim A, Steiner M, Yagupsky P. Immune response to invasive Kingella kingae infections, age-related incidence of disease, and levels of antibody to outer-membrane proteins. Clin Infect Dis. 2003;37(4):521-527
26. Yagupsky P, Slonim A. Characterization and immunogenicity of Kingella kingae outer-membrane proteins. FEMS Immunol Med Microbiol. 2005;43(1):45-50
27. Kehl-Fie TE, Miller SE, St Geme JW 3rd. Kingella kingae expresses type IV pili that mediate adherence to respiratory epithelial and synovial cells. J Bacteriol. 2008;190(21):7157-7163
28. Kehl-Fie TE, Porsch EA, Miller SE, St Geme JW 3rd. Expression of Kingella kingae type IV pili is regulated by σ54, PilS, and PilR. J Bacteriol. 2009;191(15):4976-4986
29. Amir J, Yagupsky P. Invasive Kingella kingae infection associated with stomatitis in children. Pediatr Infect Dis J. 1998;17(8):757-758
30. Kehl-Fie TE, St Geme JW 3rd. Identification and characterization of an RTX toxin in the emerging pathogen Kingella kingae. J Bacteriol. 2007;189(2):430-436
31. Kehl-Fie TE, Porsch EA, Yagupsky P, et al. Examination of type IV pilus expression and pilus-associated phenotypes in Kingella kingae clinical isolates. Infect Immun. 2010;78(4):1692-1699
32. Baticle E, Courtivron B, Baty G, et al. Pediatric osteoarticular infections caused by Kingella kingae from 1995 to 2006 at CHRU de Tours [in French]. Ann Biol Clin (Paris). 2008;66(4):454-458
33. Lundy DW, Kehl DK. Increasing prevalence of Kingella kingae in osteoarticular infections in young children. J Pediatr Orthop. 1998;18(2):262-267
34. Luhmann JD, Luhmann SJ. Etiology of septic arthritis in children: an update for the 1990s. Pediatr Emerg Care. 1999;15(1):40-42
35. Fuursted K, Arpi M, Lindblad BE, Pedersen LN. Broad-range PCR as a supplement to culture for detection of bacterial pathogens in patients with a clinically diagnosed spinal infection. Scand J Infect Dis. 2008;40(10):772-777
36. Chanal C, Tiget F, Chapuis P, Campagne D, Jan M, Sirot J. Spondylitis and osteomyelitis caused by Kingella kingae in children. J Clin Microbiol. 1987;25(12):2407-2409
37. Garron E, Viehweger E, Launay F, Guillaume JM, Jouve JL, Bollini G. Nontuberculous spondylodiscitis in children. J Pediatr Orthop. 2002;22(3):321-328
38. Ceroni D, Cherkaoui A, Kaelin A, Schrenzel J. Kingella kingae spondylodiscitis in young children: toward a new approach for bacteriological investigations? A preliminary report. J Child Orthop. 2010;4(2):173-175
39. Yagupsky P, Press J. Unsuspected Kingella kingae infections in afebrile children with mild skeletal symptoms: the importance of blood cultures. Eur J Pediatr. 2004;163(9):563-564
40. Lebel E, Rudensky B, Karasik M, Itzchaki M, Schlesinger Y. Kingella kingae infections in children. J Pediatr Orthop B. 2006;15(4):289-292
41. Caballero Rabasco MA, González Cuevas A, Martínez Roig A. Isolated bacteraemia caused by Kingella kingae [in Spanish]. An Pediatr (Barc). 2010;72(1):89-90
42. Pavlovsky M, Press J, Peled N, Yagupsky P. Blood culture contamination in pediatric patients: young children and young doctors. Pediatr Infect Dis J. 2006;25(7):611-614
43. Berkun Y, Brand A, Klar A, Halperin E, Hurvitz H. Kingella kingae endocarditis and sepsis in an infant. Eur J Pediatr. 2004;163(11):687-688
44. Wells L, Rutter N, Donald F. Kingella kingae endocarditis in a sixteen-month-old-child. Pediatr Infect Dis J. 2001;20(4):454-455
45. Rotstein A, Konstantinov IE, Penny DJ. Kingella-infective endocarditis resulting in a perforated aortic root abscess and fistulous connection between the sinus of Valsalva and the left atrium in a child. Cardiol Young. 2010;20(3):332-333
46. Youssef D, Henaine R, Di Filippo S. Subtle bacterial endocarditis due to Kingella kingae in an infant: a case report. Cardiol Young. 2010;20(4):448-450
47. Sarda H, Ghazali D, Thibault M, Leturdu F, Adams C, Le Loc'h H. Multifocal invasive Kingella kingae infection [in French]. Arch Pediatr. 1998;5(2):159-162
48. Fenollar F, Lévy PY, Raoult D. Usefulness of broad-range PCR for the diagnosis of osteoarticular infections. Curr Opin Rheumatol. 2008;20(4):463-470
49. Cherkaoui A, Ceroni D, Emonet S, Lefevre Y, Schrenzel J. Molecular diagnosis of Kingella kingae infections by specific real-time PCR assay. J Med Microbiol. 2009;58(pt 1):65-68
50. Ceroni D, Cherkaoui A, Ferey S, Kaelin A, Schrenzel J. Kingella kingae osteoarticular infections in young children: clinical features and contribution of a new specific real-time PCR assay to the diagnosis. J Pediatr Orthop. 2010;30(3):301-304
51. Cherkaoui A, Ceroni D, Ferey S, Emonet S, Schrenzel J. Pediatric osteo-articular infections with negative culture results: what about Kingella kingae [in French]? Rev Med Suisse. 2009;5(224):2235-2239
52. Stähelin J, Goledenberger D, Gnehm HE, Altwegg M. Polymerase chain reaction diagnosis of Kingella kingae arthritis in a young child. Clin Infect Dis. 1998;27(5):1328-1329
53. Moumile K, Merckx J, Glorion C, Berche P, Ferroni A. Osteoarticular infections caused by Kingella kingae in children: contribution of polymerase chain reaction to the microbiologic diagnosis. Pediatr Infect Dis J. 2003;22(9):837-839
54. Rosey AL, Abachin E, Quesnes G, et al. Development of a broad-range 16S rDNA real-time PCR for the diagnosis of septic arthritis in children. J Microbiol Methods. 2007;68(1):88-93
55. Luegmair M, Chaker M, Ploton C, Berard M. Kingella kingae: osteoarticular infections of the sternum in children: a report of six cases. J Child Orthop. 2008;2(6):443-447
56. Kugler KC, Biedenbach DJ, Jones RN. Determination of the antimicrobial activity of 29 clinically important compounds tested against fastidious HACEK group organisms. Diagn Microbiol Infect Dis. 1999;34(1):73-76
57. Jensen KT, Schonheyder H, Thomsen VF. Invitro activity of β-lactam and other antimicrobial agents against Kingella kingae. J Antimicrob Chemother. 1994;33(3):635-640
58. Yagupsky P, Katz O, Peled N. Antibiotic susceptibility of Kingella kingae isolates from respiratory carriers and patients with invasive infections. J Antimicrob Chemother. 2001;47(2):191-193
59. Saphyakhajon P, Joshi AY, Huskins WC, Henry NK, Boyce TG. Empiric antibiotic therapy for acute osteoarticular infections with suspected methicillin-resistant Staphylococcus aureus or Kingella. Pediatr Infect Dis J. 2008;27(8):765-767
60. Infectious Diseases Society of America, Emerging Infections Network. Brief report: Kingella kingae infections in children. United States, June 2001-November 2002. MMWR Morb Mortal Wkly Rep. 2004;53(11):244
61. Baraff LJ, Bass JW, Fleisher GR, et al. Practice guideline for the management of infants and children 0 to 36 months of age with fever without source. Agency for Health Policy and Research. Ann Emerg Med. 1993;22(7):1198-1210