Alpha-phellandrene promotes immune responses in normal mice through enhancing macrophage phagocytosis and natural killer cell activities

In Vivo

Volumn 27, Issue 6, 2013, Pages 809-814

  Lin, Jen Jyh ^a,b   Lin, J U Hwa ^c   Hsu, Shu Chun ^c   Weng, Shu Wen ^a,c,d   Huang, Y I Ping ^e   Tang, Nou Ying ^a   Lin, Jaung Geng ^a   Chung, Jing Gung ^c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c Taichung Hospital   (Taiwan)

^d Executive Yuan ^*  (Taiwan)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

BALB c mice; Macrophage; Natural killer cells; Phagocytosis; Phellandrene

Indexed keywords

ALPHA PHELLANDRENE; CD11B ANTIGEN; OLIVE OIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CD3+ T LYMPHOCYTE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; FLOW CYTOMETRY; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHAGOCYTOSIS; SPLEEN CELL;

BALB/C MICE; MACROPHAGE; NATURAL KILLER CELLS; PHAGOCYTOSIS; Α-PHELLANDRENE;

ANIMALS; ANTIGENS, CD19; CELL PROLIFERATION; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; IMMUNOLOGIC FACTORS; KILLER CELLS, NATURAL; LYMPHOCYTES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED BALB C; MONOTERPENES; PHAGOCYTOSIS;

EID: 84892686503     PISSN: 0258851X     EISSN: 17917549     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Djuric Z, Depper JB, Uhley V, Smith D, Lababidi S, Martino S and Heilbrun LK: Oxidative DNA damage levels in blood from women at high risk for breast cancer are associated with dietary intakes of meats, vegetables, and fruits. J Am Dietetic Assoc 98: 524-528, 1998.
2. Heo HJ and Lee CY: Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. J Agric Food Chem 52: 7514-7517, 2004.
3. Sugiura M, Ohshima M, Ogawa K, and Yano M: Chronic administration of Satsuma mandarin fruit (Citrus unshiu Marc.) improves oxidative stress in streptozotocin-induced diabetic rat liver. Biolo Pharmaceuti Bull 29: 588-591, 2006.
4. Stephens AM, Dean LL, Davis JP, Osborne JA, and Sanders TH: Peanuts, peanut oil, and fat free peanut flour reduced cardiovascular disease risk factors and the development of atherosclerosis in Syrian golden hamsters. J Food Sci 75: H116-122, 2010.
5. Li W, Tang C, Jin H and Du J: Effects of onion extract on endogenous vascular H2S and adrenomedulin in rat atherosclerosis. Curr Pharmaceut Biotechnol 12: 1427-1439, 2011.
6. Abdull Razis AF and Noor NM: Cruciferous vegetables: dietary phytochemicals for cancer prevention. Asian Pac J of Cancer Prev 14: 1565-1570, 2013.
7. Sakagami H, Takeda M, Sugaya K, Omata T, Takahashi H, Yamamura M, Hara Y, and Shimamura T: Stimulation by epigallocatechin gallate of interleukin-1 production by human peripheral blood mononuclear cells. Anticancer Res 15: 971-974, 1995.
8. Katiyar SK, Challa A, McCormick TS, Cooper KD, and Mukhtar H: Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (-)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production. Carcinogenesis 20: 2117-2124, 1999.
9. Hirao K, Yumoto H, Nakanishi T, Mukai K, Takahashi K, Takegawa D and Matsuo T: Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in tolllike receptor 2 ligand-stimulated dental pulp cells. Life Sci 86: 654-660, 2010.
10. Liu KC, Huang AC, Wu PP, Lin HY, Chueh FS, Yang JS, Lu CC, Chiang JH, Meng M, and Chung JG: Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways. Oncol Rep 26: 177-184, 2011.
11. Lu HF, Tung WL, Yang JS, Huang FM, Lee CS, Huang YP, Liao WY, Chen YL and Chung JG: In vitro suppression of growth of murine WEHI-3 leukemia cells and in vivo promotion of phagocytosis in a leukemia mice model by indole-3-carbinol. J Agric Food Chem 60: 7634-7643, 2012.
12. Chuang WY, Kung PH, Kuo CY and Wu CC: Sulforaphane prevents human platelet aggregation through inhibiting the phosphatidylinositol 3-kinase/Akt pathway. Thromb Haemosta 109: 1120-1130, 2013.
13. Cardoso CC, Pinto AC, Marques PR, Gayer CR, Afel MI, Coelho M and Sabino KC: Suppression of T and B cell responses by Pterodon pubescens seed ethanolic extract. Paki J Biol Sci 11: 2308-2313, 2008.
14. Aravindaram K and Yang NS: Anti-inflammatory plant natural products for cancer therapy. Planta Medica 76: 1103-1117, 2010.
15. Huang RY, Yu YL, Cheng WC, OuYang CN, Fu E and Chu CL: Immunosuppressive effect of quercetin on dendritic cell activation and function. J Immunol 184: 6815-6821, 2010.
16. Iscan G, Kirimer N, Demirci F, Demirci B, Noma Y and Baser KH: Biotransformation of (-)-(R)-alpha-phellandrene: antimicrobial activity of its major metabolite. Chemi & Biodiver 9: 1525-1532, 2012.
17. Al-Burtamani SK, Fatope MO, Marwah RG, Onifade AK and Al-Saidi SH: Chemical composition, antibacterial and antifungal activities of the essential oil of Haplophyllum tuberculatum from Oman. J Ethnopharmacol 96 : 107-112, 2005.
18. Lin CC, Yu CS, Yang JS, Lu CC, Chiang JH, Lin JP, Kuo CL and Chung JG: Chrysin, a natural and biologically active flavonoid, influences a murine leukemia model in vivo through enhancing populations of T- and B-cells, and promoting macrophage phagocytosis and NK cell cytotoxicity. In Vivo 26: 665-670, 2012.
19. Tsou MF, Tien N, Lu CC, Chiang JH, Yang JS, Lin JP, Fan MJ, Lu JJ, Yeh SP and Chung JG: Phenethyl isothiocyanate promotes immune responses in normal BALB/c mice, inhibits murine leukemia WEHI-3 cells, and stimulates immunomodulations in vivo. Environ Toxicol 28: 127-136, 2013.
20. Lin JG, Fan MJ, Tang NY, Yang JS, Hsia TC, Lin JJ, Lai KC, Wu RS, Ma CY, Wood WG and Chung JG: An extract of Agaricus blazei Murill administered orally promotes immune responses in murine leukemia BALB/c mice in vivo. Integr Cancer Thera 11: 29-36, 2012.
21. Yang JS, Wu CC, Kuo CL, Yeh CC, Chueh FS, Hsu CK, Wang CK, Chang CY, Ip SW, Hsu YM, Kuo WW and Chung JG: Solanum lyratum extract affected immune response in normal and leukemia murine animal in vivo. Hum Exp Toxicol 29: 359- 367, 2010.
22. Lin CC, Kuo CL, Lee MH, Hsu SC, Huang AC, Tang NY, Lin JP, Yang JS, Lu CC, Chiang JH, Chueh FS and Chung JG: Extract of Hedyotis diffusa Willd influences murine leukemia WEHI-3 cells in vivo as well as promoting T- and B-cell proliferation in leukemic mice. In Vivo 25: 633-640, 2011.
23. Hornicek FJ, Malinin GI, Thornthwaite JT, Whiteside ME, MacLeod CL and Malinin TI: Effect of mitogens on the cell cycle progression and the quantification of T-lymphocyte surface markers in acquired immune deficiency syndrome. J Leuk Biol 42: 122-127, 1987.
24. Gougeon ML: Does apoptosis contribute to CD4 T cell depletion in human immunodeficiency virus infection ? Cell Death Differ 2: 1-8, 1995.
25. Bhardwaj N, Nash TW and Horwitz MA: Interferon-gammaactivated human monocytes inhibit the intracellular multiplication of Legionella pneumophila. J Immunol 137: 2662-2669, 1986.
26. Nash TW, Libby DM and Horwitz MA: IFN-gamma-activated human alveolar macrophages inhibit the intracellular multiplication of Legionella pneumophila. J Immunol 140: 3978-3981, 1988.
27. + T-cells through IL-12 produced by Listeria -induced macrophages. Science 260: 547-549, 1993.
28. Asano N, Fujimoto M, Yazawa N, Shirasawa S, Hasegawa M, Okochi H, Tamaki K, Tedder TF and Sato S: B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. Am J Pathol 165: 641- 650, 2004.
29. + B-lymphocytes. Viral Immunol 23: 369-376, 2010.
30. Horwitz MA: Cell-mediated immunity in Legionnaires' disease. J Clin Investi 71: 1686-1697, 1983.