Screening method to identify inhibitors of siderophore biosynthesis in the opportunistic fungal pathogen, aspergillus fumigatus

Letters in Applied Microbiology

Volumn 49, Issue 1, 2009, Pages 8-13

  Pinto, L J ^a   Moore, M M ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

96 well plate assay; Antifungal; Aspergillosis; Filter plates; Iron; Ornithine oxygenase

Indexed keywords

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; FUNGICIDES;

96-WELL PLATE ASSAY; ANTIFUNGAL; ASPERGILLOSIS; FILTER PLATES; ORNITHINE OXYGENASE;

THROUGHPUT;

AMPHOTERICIN B; SIDEROPHORE;

FUNGUS; IDENTIFICATION METHOD; INHIBITION; SIDEROPHORE; VIRULENCE;

ARTICLE; ASPERGILLUS FUMIGATUS; BIOSYNTHESIS; CONTROLLED STUDY; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS GROWTH; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; NONHUMAN; SPECTROPHOTOMETRY;

ASPERGILLUS FUMIGATUS; FUNGI;

EID: 67249090804     PISSN: 02668254     EISSN: 1472765X     Source Type: Journal    
DOI: 10.1111/j.1472-765X.2009.02582.x     Document Type: Article

References (17)

1. Anon (2004) Laboratory Biosafety Guidelines. Ottawa, Canada : Publication no. 4252, Population and Public Health Branch of Canada, Centre for Emergency Preparedness and Response.
2. Brakhage, A.A. (2005) Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinants. Curr Drug Targets 6, 875 886. (Pubitemid 41672449)
3. Grimm, P.W. Allen, P.J. (1954) Promotion by zinc of the formation of cytochromes in Ustilago sphaerogena. Plant Physiol 29, 369 377.
4. Haas, H., Eisendle, M. Turgeon, B.G. (2008) Siderophores in fungal physiology and virulence. Ann Rev Phytopathol 46, 148 187.
5. Hissen, A.H.T., Chow, J.M.T., Pinto, L.J. Moore, M.M. (2004) Survival of Aspergillus fumigatus in serum involves removal of iron from transferrin: the role of siderophores. Infect Immun 72, 1402 1408. (Pubitemid 38263762)
6. 5-oxygenase, is required for virulence. Infect Immun 73, 5493 5503. (Pubitemid 41192983)
7. Hu, W., Sillaots, S., Lemieux, S., Davison, J., Kauffman, S., Breton, A., Linteau, A., Xin, C. et al. (2007) Essential gene identification and drug target prioritization in Aspergillus fumigatus. PLoS Pathog 3, e24.
8. Morgan, J., Wannemuehler, K.A., Marr, K.A., Hadley, S., Kontoyiannis, D.P., Walsh, T.J., Fridkin, S.K., Pappas, P.G. et al. (2005) Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation: interim results of a prospective multicenter surveillance program. Med Mycol 43, 49 58.
9. Mukherjee, P.K., Sheehan, D.J., Hitchcock, C.A. Ghannoum, M.A. (2005) Combination treatment of invasive fungal infections. Clin Microbiol Rev 18, 163 194. (Pubitemid 40170667)
10. National Committee for Clinical Laboratory Standards (NCCLS) (2002) Reference Method for Broth Dilution Antifungal Susceptibility Testing Offilamentous Fungi. Approved standard M38-A. Wayne, PA, USA : National Committee for Clinical Laboratory Standards.
11. Odds, F.C., Brown, A.J.P. Gow, N.A.R. (2003) Antifungal agents: mechanisms of action. Trends Microbiol 11, 272 279. (Pubitemid 36725017)
12. Payne, S.M. (1994) Detection, isolation, and characterization of siderophores. Meth Enzymol 235, 329 44.
13. Peter, J., Armstrong, D., Lyman, C.A. Walsh, T.J. (2005) Use of fluorescent probes to determine MICs of amphotericin B and caspofungin against Candida spp. and Aspergillus spp. J Clin Microbiol 43, 3788 3792. (Pubitemid 41129661)
14. Plattner, H.J. Diekmann, H. (1994) Enzymology of siderophore biosynthesis. In Metal Ions in Fungi ed. Winkelmann, G. Winge, D.R. pp 99 116. New York : Marcel Dekker.
15. Schrettl, M., Bignell, E., Kragl, C., Joechl, C., Rogers, T., Arst, H.N. Jr., Haynes, K. Haas, H. (2004) Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med 200, 1213 1219. (Pubitemid 39507061)
16. Schrettl, M., Bignell, E., Kragl, C., Sabiha, Y., Loss, O., Eisendle, M., Wallner, A., Arst, H.N. Jr. et al. (2007) Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathog 3, e128.
17. Takase, H., Nitanai, H., Hoshino, K. Otani, T. (2000) Impact of siderophore production on Pseudomonas aeruginosa infections in immunosuppressed mice. Infect Immun 68, 1834 1839. (Pubitemid 30164806)