Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 2, 2014, Pages 216-229

  Bhowmik, Shiva ^a,d   Jones, David H ^c   Chiu, Hsien Po ^c   Park, In Hee ^c   Chiu, Hsiu Ju ^c,d   Axelrod, Herbert L ^c,d   Farr, Carol L ^a,d   Tien, Henry J ^a,d   Agarwalla, Sanjay ^b   Lesley, Scott A ^a,b,d  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^d Joint Center for Structural Genomics   (United States)

Author keywords

Gut microbe mediated human metabolite; Nicotinamide hydroxyl adduct; Primary bile acid; Proton relay; Secondary bile acid; Short chain dehydrogenase reductase; Steroid dehydrogenase

Indexed keywords

NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROTEIN; PROTEIN BAIA; UNCLASSIFIED DRUG;

ARTICLE; BILE ACID SYNTHESIS; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME KINETICS; ENZYME STRUCTURE; INTESTINE FLORA; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; STEADY STATE;

CLOSTRIDIUM SCINDENS;

GUT MICROBE MEDIATED HUMAN METABOLITE; NICOTINAMIDE-HYDROXYL ADDUCT; PRIMARY BILE ACID; PROTON RELAY; SECONDARY BILE ACID; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; STEROID DEHYDROGENASE;

APOENZYMES; BACTERIAL PROTEINS; BILE ACIDS AND SALTS; CATALYTIC DOMAIN; CLOSTRIDIUM; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROXYSTEROID DEHYDROGENASES; KINETICS; MODELS, MOLECULAR; NAD;

EID: 84892676591     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24353     Document Type: Article

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