Effects of triptolide on degeneration of dendritic spines induced by Aβ1-40 injection in rat hippocampus

Neurological Sciences

Volumn 35, Issue 1, 2014, Pages 35-40

  Wan, Bin ^a   Hu, Xiaoling ^a   Nie, Jing ^a   Zhou, Ming ^a   Yang, Baolin ^a   Li, Yaobing ^a   Wen, Wei ^a   Lü, Cheng ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Dendritic spines; Hippocampus; Triptolide

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; SODIUM CHLORIDE; TRIPTOLIDE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; CELL DENSITY; CELL STRUCTURE; CONTROLLED STUDY; DENDRITIC SPINE; GOLGI STAIN; HIPPOCAMPUS; MALE; MICROINJECTION; NONHUMAN; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; DITERPENES; EPOXY COMPOUNDS; HIPPOCAMPUS; IMMUNOSUPPRESSIVE AGENTS; MALE; NERVE DEGENERATION; PEPTIDE FRAGMENTS; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84892673094     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-013-1463-0     Document Type: Article

References (27)

1. Yu W, Lu B (2012) Synapses and dendritic spines as pathogenic targets in Alzheimer's disease. Neural Plast. doi: 10.1155/2012/247150
2. Penzes P, VanLeeuwen JE (2011) Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease. Brain Res Rev 67:184-192
3. Calabrese B, Wilson MS, Halpain S (2006) Development and regulation of dendritic spine synapses. Physiology (Bethesda) 21:38-47 (Pubitemid 43752516)
4. Scheff SW, Price DA (1993) Synapse loss in the temporal lobe in Alzheimer's disease. Ann Neurol 33:190-199 (Pubitemid 23039928)
5. Grutzendler J, Helmin K, Tsai J, Gan WB (2007) Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease. Ann N Y Acad Sci 1097:30-39 (Pubitemid 47084880)
6. Broussard GJ, Mytar J, Li RC, Klapstein GJ (2012) The role of inflammatory processes in Alzheimer's disease. Inflammopharmacology 20:109-126
7. Rao JS, Kellom M, Kim HW, Rapoport SI, Reese EA (2012) Neuroinflammation and synaptic loss. Neurochem Res 37:903-910
8. Liu Q (2011) Triptolide and its expanding multiple pharmacological functions. Int Immunopharmacol 11:377-383
9. Zheng Y, Zhang WJ, Wang XM (2013) Triptolide with potential medicinal value for diseases of the central nervous system. CNS Neurosci Ther 19:76-82
10. Wang J, Shi ZQ, Xu X, Xin GZ, Chen J, Qi LW, Li P (2013) Triptolide inhibits amyloid-β production and protects neural cells by inhibiting CXCR2 activity. J Alzheimers Dis 33:217-229
11. Gu M, Zhou HF, Xue B, Niu DB, He QH, Wang XM (2004) Effect of Chinese herb Tripterygium wilfordii Hook F monomer triptolide on apoptosis of PC12 cells induced by Aβ1-42. Acta Physiol S 56:73-78
12. Nie J, Zhou M, Lü C, Hu XL, Wan B, Yang BL, Li YB (2012) Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model. Int Immunopharmacol 13:175-180
13. Li LX, Dai JP, Ru LQ, Yin GF, Zhao B (2004) Effects of tanshinone on neuropathological changes induced by amyloid beta-peptide(1-40) injection in rat hippocampus. Acta Pharmacol Sin 25:861-868 (Pubitemid 38915444)
14. Xuan A, Long D, Li J, Ji W, Zhang M, Hong L, Liu J (2012) Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer's disease. J Neuroinflammation. doi: 10.1186/1742-2094-9-202
15. Gong X, Lu X, Zhan L, Sui H, Qi X, Ji Z, Niu X, Liu L (2010) Role of the SNK-SPAR pathway in the development of Alzheimer's disease. IUBMB Life 62:214-221
16. Castejon OJ, Castejon HV, Diaz M, Castellano A (2001) Consecutive light microscopy, scanning-transmission electron microscopy and transmission electron microscopy of traumatic human brain oedema and ischaemic brain damage. Histol Histopathol 16:1117-1134 (Pubitemid 32994457)
17. He FQ, Qiu BY, Zhang XH, Li TK, Xie Q, Cui DJ, Huang XL, Gan HT (2011) Tandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer's disease induced by amyloid-β(1-42). Brain Res 1384:89-96
18. Bisagno V, Ferrini M, Ríos H, Zieher LM, Wikinski SI (2000) Chronic corticosterone impairs inhibitory avoidance in rats: possible link with atrophy of hippocampal CA3 neurons. Pharmacol Biochem Behav 66:235-240 (Pubitemid 30394607)
19. Jia H, Zhang B, Liu Y, Zhang X, Ji Y, Li X, Liu R (2012) Changes of dendritic morphology and spine density in hippocampal CA1 pyramidal cells of chronic cerebral ischemic rats. Chin J Pathophysiol 28:177-180
20. Mavroudis IA, Fotiou DF, Manani MG, Njaou SN, Frangou D, Costa VG, Baloyannis SJ (2011) Dendritic pathology and spinal loss in the visual cortex in Alzheimer's disease: a Golgi study in pathology. Int J Neurosci 121:347-354
21. Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL (2007) Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 27:796-807 (Pubitemid 46174498)
22. Kondo S, Kohsaka S, Okabe S (2011) Long-term changes of spine dynamics and microglia after transient peripheral immune response triggered by LPS in vivo. Mol Brain. doi: 10.1186/1756-6606-4-27
23. Mandolesi L, De Bartolo P, Foti F, Gelfo F, Federico F, Leggio MG, Petrosini L (2008) Environmental enrichment provides a cognitive reserve to be spent in the case of brain lesion. J Alzheimers Dis 15:11-28
24. De Bartolo P, Gelfo F, Mandolesi L, Foti F, Cutuli D, Petrosini L (2009) Effects of chronic donepezil treatment and cholinergic deafferentation on parietal pyramidal neuron morphology. J Alzheimers Dis 17:177-191
25. Jiao J, Xue B, Zhang L, Gong Y, Li K, Wang H, Jing L, Xie J, Wang X (2008) Triptolide inhibits amyloid-beta1-42-induced TNF-alpha and IL-1beta production in cultured rat microglia. J Neuroimmunol 205:32-36
26. Lei DL, Li MB, Xiong K, Deng XH, Luo XG (2009) Triptolide inhibits the Aβ deposition and senile plaques formation in the hippocampus of APP/PS1 double transgenic mice. Acta Anat S 40:369-373
27. Pan XD, Chen XC, Zhu YG, Chen LM, Zhang J, Huang TW, Ye QY, Huang HP (2009) Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling. Glia 57:1227-1238