Effects of tanshinone on neuropathological changes induced by amyloid β-peptide1-40 injection in rat hippocampus

Acta Pharmacologica Sinica

Volumn 25, Issue 7, 2004, Pages 861-868

  Li, Long Xuan ^a   Dai, Jia Pei ^b   Ru, Li Qiang ^c   Yin, Guang Fu ^c   Zhao, Bin ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Acetylcholinesterase; Amyloid beta protein; Hippocampus; Nitric oxide synthase; Tanshinone

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PEPTIDE[1-40]; AMYLOID BETA PROTEIN; HERBACEOUS AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; TANSHINONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DENTATE GYRUS; DOWN REGULATION; DRUG BRAIN LEVEL; DRUG EFFECT; HIPPOCAMPUS; HISTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; NERVE CELL; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; SALVIA MILTIORRHIZA; UPREGULATION; WESTERN BLOTTING;

ACETYLCHOLINESTERASE; AMYLOID BETA-PROTEIN; ANIMALS; HIPPOCAMPUS; INJECTIONS; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; PEPTIDE FRAGMENTS; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 3142691107     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Shen YX, Wei W, Yang J, Liu C. Improvement of melatonin on learning and memory impairment induced by amyloid beta-peptide 25-35 in elder rats. Acta Pharmacol Sin 2001; 22: 797-803.
2. Yamaguchi Y, Matsuno T, Kawashima S. Antiamnesic effect of azaindolizinone derivative ZSET845 on impaired learning and decreased ChAT activity induced by amyloid-β 25-35 in the rat. Brain Res 2002: 259-65.
3. 2+ channel currents in primary cultures of rat cortical neurones by amyloid beta protein (1-40) is dependent on solubilit status. Brain Res 2002; 956: 254-61.
4. Stephan A, Laroche S, Davis S. Generation of aggregated β amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits. J Neurosci 2001; 21: 5703-14.
5. Olariu A, Yamada K, Mamiya T, Hefco V, Nabeshima T. Memory impairment induced by chronic intracerebroventricular infusion of beta-amyloid (1-40) involves downregulation of protein kinase C. Brain Res 2002; 957: 278-86.
6. Van der Staay FJ, Raaijmakers WGM, Lammers AJJC, Tonnaer JA. Selective fimbria lesions impair acquisition of working and reference memory of rats in a complex spatial discrimination task. Behav Brain Res 1989; 32: 151-61.
7. Law A, Gauthier S, Quirion R. Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type. Brain Res Rev 2001; 35: 73-96.
8. Keith T, Linda J, Van E. Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1 beta and tumor necrosis factor-α (TNFα)-dependent, and involves a TNFα receptor-associated factor- and NFκB-inducing kinase-dependent signaling mechanism. J Biol Chem 2000; 275: 7918-24.
9. Ji XY, Tan BKH, Zhu YZ. Salvia miltiorrhiza and ischemic diseases. Acta Pharmacol Sin 2000; 21: 1089-94.
10. He LN, Yang J, Jiang Y, Wang J, Liu C, He SB. Protective effect of tanshinone on injured cultured PC12 cells in vitro. China J Chin Mater Med 2001; 26: 413-6.
11. Lam BY, Lo AC, Sun X, Chung SK, Sucher NJ. Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice. Phytomedicine 2003; 10: 286-91.
12. Liu XJ, Wu WT. Effects of ligustrazine, tanshinone IIA, ubiquinone, and idebenone on mouse water maze performance. Acta Pharmacol Sin 1999; 20: 987-90.
13. Li LX, Ru LQ. Influence of tanshinone on learning and memory impairment induced by amyloid peptide 1-40 in rats. Chin J Gerontol 2003; 23: 294-7.
14. Morimoto K, Yoshimi k, Tonohiro T, Yamada N, Oda T, Kaneko I. Co-injection of β-amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons. Neuroscience 1998; 84: 479-87.
15. Hisao T, Hiroshi K, Toshihiro M. Visualization of detailed acetylcholinesterase fiber and neuron staining in rat brain by a sensitive histochemical procedure. J Histochem Cryochem 1986; 34: 1431-8.
16. Nitta A, Itoh A, Hasegawa T, Nabeshima T. β-amyloid protein induced Alzheimer's disease animal model. Neurosci Lett 1994; 170: 63-6.
17. 25-35 is not neurotoxic to the septo-hippocampal cholinergic system in rats. Chin J Neuroanatomy 1999; 15: 277-80.
18. Lüth HJ, Münch G, Arendt T. Aberrant expression of NOS isforms in Alzheimer's disease is structurally related to nitrotyrosine formation. Brain Res 2002; 953: 135-43.
19. Weldon DT, Rogers SD, Ghilardi JR, Finke MP, Cleary JP, O'Hare E, et al. Fibrillar β-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. J Neurosci 1998; 18: 2161-73.
20. Akama KT, Albanese C, Pestell RG, Van Eldik LJ. Amyloid β-peptide stimulates nitric oxide production in astrocyte through a NFκB-dependent mechanism. Proc Natl Acad Sci USA 1998; 95: 5795-9.
21. Lüth HJ, Holzer M, Gärtner U, Staufenbiel M, Arendt T. Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology. Brain Res 2001; 913: 57-67.
22. Thorns V, Hansen L, Masliah E. nNOS expression neurons in the entorhinal cortex and hippocampus are affected in patients with Alzheimer's disease. Exp Neurol 1998; 150: 14-20.
23. Benzing WC, Mufson EJ. Increased number of NADPH-d-positive neurons within the substantia innominata in Alzheimer's disease. Brain Res 1995; 670: 351-5.
24. Rebeck GW, Marzloff K, Hyman BT. The pattern of NADPH-diaphorase staining, a marker of nitrix oxide synthase activity, is altered in the perforant pathway terminal zone in Alzheimer's disease. Neurosci Lett 1993; 152: 165-8.
25. Mufson EJ, Brandabur MM. Sparing of NADPH-diaphorase striatal neurons in Parkinson's and Alzheimer's disease. Neuroreport 1994; 5: 705-8.