Intraclonal variations among streptococcus pneumoniae isolates influence the likelihood of invasive disease in children

Journal of Infectious Diseases

Volumn 209, Issue 3, 2014, Pages 377-388

  Browall, Sarah ^a   Norman, Martin ^a   Tångrot, Jeanette ^e   Galanis, Ilias ^a   Sjöström, Karin ^a   Dagerhamn, Jessica ^a   Hellberg, Christel ^a   Pathak, Anuj ^a   Spadafina, Tiziana ^a   Sandgren, Andreas ^a,f   Bättig, Patrick ^a   Franzén, Oscar ^b   Andersson, Björn ^b   Örtqvist, Åke ^c   Normark, Staffan ^a   Henriques Normark, Birgitta ^a,d  

^a Tumor   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c STOCKHOLM COUNTY COUNCIL   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e UMEÅ UNIVERSITY   (Sweden)

^f EUROPEAN CENTRE FOR DISEASE PREVENTION AND CONTROL ECDC   (Sweden)

Author keywords

bacteriophages; factor H binding; intraclonal variation; invasive disease potential; PcpA; pneumococcal infections; PspA; PspC; Streptococcus pneumoniae; surface proteins

Indexed keywords

BACTERIAL PROTEIN; COMPLEMENT FACTOR H; PNEUMOCOCCAL CHOLINE BINDING PROTEIN C; PNEUMOCOCCAL SURFACE PROTEIN A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIOPHAGE; BACTERIUM CARRIER; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CHILD; CLONAL VARIATION; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; IN VIVO STUDY; INVASIVE SPECIES; MOUSE; MULTILOCUS SEQUENCE TYPING; NONHUMAN; NUCLEOTIDE SEQUENCE; PCPA GENE; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PSPA GENE; PULSED FIELD GEL ELECTROPHORESIS; SEROTYPE; STREPTOCOCCUS PNEUMONIAE;

BACTERIOPHAGES; FACTOR H BINDING; INTRACLONAL VARIATION; INVASIVE DISEASE POTENTIAL; PCPA; PNEUMOCOCCAL INFECTIONS; PSPA; PSPC; STREPTOCOCCUS PNEUMONIAE; SURFACE PROTEINS;

ADOLESCENT; ANIMALS; ANTIGENS, BACTERIAL; CARRIER STATE; CHILD; CHILD, PRESCHOOL; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, GEL, PULSED-FIELD; FEMALE; GENETIC VARIATION; GENOME, BACTERIAL; GENOTYPE; HUMANS; INFANT; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR TYPING; PNEUMOCOCCAL INFECTIONS; PROPHAGES; SEQUENCE ANALYSIS, DNA; STREPTOCOCCUS PHAGES; STREPTOCOCCUS PNEUMONIAE; VIRULENCE;

EID: 84892661349     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit481     Document Type: Article

References (33)

1. Nunes S, Sa-Leao R, Carrico J, et al. Trends in drug resistance, serotypes, and molecular types of Streptococcus pneumoniae colonizing preschool-age children attending day care centers in Lisbon, Portugal: a summary of 4 years of annual surveillance. J Clin Microbiol 2005; 43:1285-93.
2. Henriqus Normark B, Christensson B, Sandgren A, et al. Clonal analysis of Streptococcus pneumoniae nonsusceptible to penicillin at day-care centers with index cases, in a region with low incidence of resistance: emergence of an invasive type 35B clone among carriers. Microb Drug Resist 2003; 9:337-44.
3. O'Brien KL, Wolfson LJ, Watt JP, et al. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 2009; 374:893-902.
4. Brueggemann AB, Griffiths DT, Meats E, Peto T, Crook DW, Spratt BG. Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype-and clone-specific differences in invasive disease potential. J Infect Dis 2003; 187:1424-32.
5. Sandgren A, Sjostrom K, Olsson-Liljequist B, et al. Effect of clonal and serotype-specific properties on the invasive capacity of Streptococcus pneumoniae. J Infect Dis 2004; 189:785-96.
6. Sjostrom K, Spindler C, Ortqvist A, et al. Clonal and capsular types decide whether pneumococci will act as a primary or opportunistic pathogen. Clin Infect Dis 2006; 42:451-9.
7. Blomberg C, Dagerhamn J, Dahlberg S, et al. Pattern of accessory regions and invasive disease potential in Streptococcus pneumoniae. J Infect Dis 2009; 199:1032-42.
8. Dagerhamn J, Blomberg C, Browall S, Sjostrom K, Morfeldt E, Henriques-Normark B. Determination of accessory gene patterns predicts the same relatedness among strains of Streptococcus pneumoniae as sequencing of housekeeping genes does and represents a novel approach in molecular epidemiology. J Clin Microbiol 2008; 46:863-8.
9. Sjostrom K, Blomberg C, Fernebro J, et al. Clonal success of piliated penicillin nonsusceptible pneumococci. Proc Natl Acad Sci USA 2007; 104:12907-12.
10. Enright MC, Spratt BG. A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology 1998; 144 (Pt 11):3049-60.
11. Coffey TJ, Enright MC, Daniels M, et al. Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae. Mol Microbiol 1998; 27:73-83.
12. Hermans PW, Sluijter M, Hoogenboezem T, Heersma H, van Belkum A., Groot R. Comparative study of five different DNA fingerprint techniques for molecular typing of Streptococcus pneumoniae strains. J Clin Microbiol 1995; 33:1606-12.
13. Tenover FC, Arbeit RD, Goering RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995; 33:2233-9.
14. http://spneumoniae.mlst.net/. Accessed 2008.
15. Feil EJ, Li BC, Aanensen DM, Hanage WP, Spratt BG. eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data. J Bacteriol 2004; 186:1518-30.
16. Romero P, Garcia E, Mitchell TJ. Development of a prophage typing system and analysis of prophage carriage in Streptococcus pneumoniae. Appl Environ Microbiol 2009; 75:1642-9.
17. Iannelli F, Oggioni MR, Pozzi G. Allelic variation in the highly polymorphic locus pspC of Streptococcus pneumoniae. Gene 2002; 284:63-71.
18. Hollingshead SK, Becker R, Briles DE. Diversity of PspA: mosaic genes and evidence for past recombination in Streptococcus pneumoniae. Infect Immun 2000; 68:5889-900.
19. Margulies M, Egholm M, Altman WE, et al. Genome sequencing in microfabricated high-density picolitre reactors. Nature 2005; 437:376-80.
20. Lukashin AV, Borodovsky M. GeneMark.hmm: new solutions for gene finding. Nucleic Acids Res 1998; 26:1107-15.
21. Kurtz S, Phillippy A, Delcher AL, et al. Versatile and open software for comparing large genomes. Genome Biol 2004; 5:R12.
22. Carver T, Berriman M, Tivey A, et al. Artemis and ACT: viewing, annotating and comparing sequences stored in a relational database. Bioinformatics 2008; 24:2672-6.
23. Giefing C, Meinke AL, Hanner M, et al. Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies. J Exp Med 2008; 205:117-31.
24. Briles DE, Hollingshead SK, Paton JC, et al. Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae. J Infect Dis 2003; 188:339-48.
25. Balachandran P, Brooks-Walter A, Virolainen-Julkunen A, Hollingshead SK, Briles DE. Role of pneumococcal surface protein C in nasopharyngeal carriage and pneumonia and its ability to elicit protection against carriage of Streptococcus pneumoniae. Infect Immun 2002; 70:2526-34.
26. Ren B, McCrory MA, Pass C, et al. The virulence function of Streptococcus pneumoniae surface protein A involves inhibition of complement activation and impairment of complement receptor-mediated protection. J Immunol 2004; 173:7506-12.
27. Hakansson A, Roche H, Mirza S, McDaniel LS, Brooks-Walter A, Briles DE. Characterization of binding of human lactoferrin to pneumococcal surface protein A. Infect Immun 2001; 69:3372-81.
28. Glover DT, Hollingshead SK, Briles DE. Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsis. Infect Immun 2008; 76:2767-76.
29. Hammerschmidt S, Agarwal V, Kunert A, Haelbich S, Skerka C, Zipfel PF. The host immune regulator factor H interacts via two contact sites with the PspC protein of Streptococcus pneumoniae and mediates adhesion to host epithelial cells. J Immunol 2007; 178:5848-58.
30. Dave S, Brooks-Walter A, Pangburn MK, McDaniel LS. PspC, a pneumococcal surface protein, binds human factor H. Infect Immun 2001; 69:3435-7.
31. Janulczyk R, Iannelli F, Sjoholm AG, Pozzi G, Bjorck L. Hic, a novel surface protein of Streptococcus pneumoniae that interferes with complement function. J Biol Chem 2000; 275:37257-63.
32. Yuste J, Khandavilli S, Ansari N, et al. The effects of PspC on complement-mediated immunity to Streptococcus pneumoniae vary with strain background and capsular serotype. Infect Immun 2010; 78:283-92.
33. Agarwal V, Asmat TM, Luo S, Jensch I, Zipfel PF, Hammerschmidt S. Complement regulator Factor H mediates a two-step uptake of Streptococcus pneumoniae by human cells. J Biol Chem 2010; 285:23486-95.