The virulence function of Streptococcus pneumoniae surface protein A involves inhibition of complement activation and impairment of complement receptor-mediated protection

Journal of Immunology

Volumn 173, Issue 12, 2004, Pages 7506-7512

  Ren, Bing ^a   McCrory, Mark A ^b   Pass, Christina ^b   Bullard, Daniel C ^c   Ballantyne, Christie M ^d   Xu, Yuanyuan ^b   Briles, David E ^a   Szalai, Alexander J ^b  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD18 ANTIGEN; COMPLEMENT; COMPLEMENT COMPONENT C3B; COMPLEMENT RECEPTOR; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PROTEIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BACTEREMIA; BACTERIAL VIRULENCE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT DEPOSITION; COMPLEMENT INHIBITION; CONTROLLED STUDY; FLOW CYTOMETRY; HOST RESISTANCE; MOUSE; MUTANT; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; SURVIVAL RATE; WESTERN BLOTTING; WILD TYPE;

EID: 10344233687     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.12.7506     Document Type: Article

References (34)

1. Briles, D. E., S. K. Hollingshead, E. Swiatlo, A. Brooks-Walter, A. Szalai, A. Virolainen, L. S. McDaniel, K. A. Benton, P. White, K. Prellner, et al. 1997. PspA and PspC: their potential for use as pneumococcal vaccines. Microb. Drug Resist. 3:401.
2. Briles, D. E., J. Yother, and L. S. McDaniel. 1988. Role of pneumococcal surface protein A in the virulence of Streptococcus pneumoniae. Rev. Infect. Dis. 10(Suppl. 2):S372.
3. McDaniel, L. S., J. Yother, M. Vijayakumar, L. McGarry, W. R. Guild, and D. E. Briles. 1987. Use of insertional inactivation to facilitate studies of biological properties of pneumococcal surface protein A (PspA). J. Exp. Med. 165:381.
4. Ren, B., A. J. Szalai, O. Thomas, S. K. Hollingshead, and D. E. Briles. 2003. Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae. Infect. Immun. 71:75.
5. Tu, A. H., R. L. Fulgham, M. A. McCrory, D. E. Briles, and A. J. Szalai. 1999. Pneumococcal surface protein A inhibits complement activation by Streptococcus pneumoniae. Infect. Immun. 67:4720.
6. Abeyta, M. 1999. Pneumococcal surface protein A and capsular polysaccharide in virulence of Streptococcus pneumoniae. Ph D. thesis. University of Alabama, Birmingham, AL.
7. Ren, B., A. J. Szalai, S. K. Hollingshead, and D. E. Briles. 2004. Effects of PspA and antibodies to PspA on activation and deposition of complement on the pneumococcal surface. Infect. Immun. 72:114.
8. Prodinger, W. M., R. Wurzner, A. Erdei, and M. P. Dierich. 1999. Complement. In Fundamental Immunology. W. E. Paul, ed. Lippincott-Raven, Philadelphia, p. 967.
9. Law, S. K., and A. W. Dodds. 1997. The internal thioester and the covalent binding properties of the complement proteins C3 and C4. Protein Sci. 6:263.
10. Agramonte-Hevia, J., A. Gonzalez-Arenas, D. Barrera, and M. Velasco-Velazquez. 2002. Gram-negative bacteria and phagocytic cell interaction mediated by complement receptor 3. FEMS Immunol. Med. Microbiol. 34:255.
11. Wright, S. D. 1992. Receptors for complement and the biology of phagocytosis. In Basic Principles and Clinical Correlates. J. I. Gallin, I. M. Goldstein, and R. Snyderman, eds. Raves Press, New York, p. 477.
12. Birmingham, D. J., and L. A. Hebert. 2001. CR1 and CR1-like: the primate immune adherence receptors. Immunol. Rev. 180:100.
13. Krych-Goldberg, M., and J. P. Atkinson. 2001. Structure-function relationships of complement receptor type 1. Immunol. Rev. 180:112.
14. Klickstein, L. B., S. F. Barbashov, T. Liu, R. M. Jack, and A. Nicholson-Weller. 1997. Complement receptor type 1 (CR1, CD35) is a receptor for C1q. Immunity 7:345.
15. Kalli, K. R., and D. T. Fearon. 1994. Binding of C3b and C4b by the CR1-like site in murine CR1. J. Immunol. 152:2899.
16. Molina, H., T. Kinoshita, C. B. Webster, and V. M. Holers. 1994. Analysis of C3b/C3d binding sites and factor I cofactor regions within mouse complement receptors 1 and 2. 7. Immunol 153:789.
17. Hourcade, D., M. K. Liszewski, M. Krych-Goldberg, and J. P. Atkinson. 2000. Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1. Immunopharmacology 49:103.
18. Fearon, D. T., and M. C. Carroll. 2000. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu. Rev. Immunol. 18:393.
19. Haas, K. M., M. Hasegawa, D. A. Steeber, J. C. Poe, M. D. Zabel, C. B. Bock, D. R. Karp, D. E. Briles, J. H. Weis, and T. F. Tedder. 2002. Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. Immunity 17:713.
20. Harris, E. S., T. M. McIntyre, S. M. Prescott, and G. A. Zimmerman. 2000. The leukocyte integrins. J. Biol. Chem. 275:23409.
21. Ahearn, J. M., M. B. Fischer, D. Croix, S. Goerg, M. Ma, J. Xia, X. Zhou, R. G. Howard, T. L. Rothstein, and M. C. Carroll. 1996. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity 4:251.
22. Ding, Z. M., J. E. Babensee, S. I. Simon, H. Lu, J. L. Perrard, D. C. Bullard, X. Y. Dai, S. K. Bromley, M. L. Dustin, M. L. Entman, et al. 1999. Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J. Immunol. 163:5029.
23. Berlin-Rufenach, C., F. Otto, M. Mathies, J. Westermann, M. J. Owen, A. Hamann, and N. Hogg. 1999. Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. J. Exp. Med. 189:1467.
24. Briles, D. E., C. Forman, S. Hudak, and J. L. Claflin. 1982. Anti-PC antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae. J. Exp. Med. 156:1177.
25. Briles, D. E., C. Forman, J. C. Horowitz, J. E. Volanakis, W. H. Benjamin, Jr., L. S. McDaniel, J. Eldridge, and J. Brooks. 1989. Antipneumococcal effects of C-reactive protein and monoclonal antibodies to pneumococcal cell wall and capsular antigens. Infect. Immun. 57:1457.
26. Yother, J., and D. E. Briles. 1992. Structural properties and evolutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysis. J. Bacteriol 174:601.
27. Hosea, S. W., E. J. Brown, and M. M. Frank. 1980. The critical role of complement in experimental pneumococcal sepsis. J. Infect. Dis. 142:903.
28. Brown, J. S., T. Hussell, S. M. Gilliland, D. W. Holden, J. C. Paton, M. R. Ehrenstein, M. J. Walport, and M. Botto. 2002. The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc. Natl. Acad. Sci. USA 99:16969.
29. Briles, D. E., C. Forman, and M. Crain. 1992. Mouse antibody to phosphocholine can protect mice from infection with mouse-virulent human isolates of Streptococcus pneumoniae. Infect. Immun. 60:1957.
30. Yother, J., C. Forman, B. M. Gray, and D. E. Briles. 1982. Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody. Infect. Immun. 36:184.
31. Waytes, A. T., A. Malbran, D. A. Bobak, and L. F. Fries. 1991. Pre-ligation of CR1 enhances IgG-dependent phagocytosis by cultured human monocytes. J. Immunol. 146:2694.
32. Alexander, J. J., B. K. Hack, P. N. Cunningham, and R. J. Quigg. 2001. A protein with characteristics of factor H is present on rodent platelets and functions as the immune adherence receptor. J. Biol Chem. 276:32129.
33. Scharffetter-Kochanek, K., H. Lu, K. Norman, N. van Nood, F. Munoz, S. Grabbe, M. McArthur, I. Lorenzo, S. Kaplan, K. Ley, et al. 1998. Spontaneous skin ulceration and defective T cell function in CD18 null mice. J. Exp. Med 188:119.
34. Prince, J. E., C. F. Brayton, M. C. Fossett, J. A. Durand, S. L. Kaplan, C. W. Smith, and C. M. Ballantyne. 2001. The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae. J. Immunol. 166:7362.