Fasting and postprandial levels of ghrelin, leptin and insulin in lean, obese and anorexic subjects

Przeglad Gastroenterologiczny

Volumn 8, Issue 6, 2013, Pages 383-389

  Korek, Emilia ^a   Krauss, Hanna ^a   Gibas Dorna, Magdalena ^a   Kupsz, Justyna ^a   Pia̧tek, Małgorzata ^a   Pia̧tek, Jacek ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Anorexia nervosa; Ghrelin; Insulin; Leptin; Obesity

Indexed keywords

GHRELIN; INSULIN; LEPTIN;

ADULT; ANOREXIA NERVOSA; ARTICLE; BLOOD SAMPLING; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; FOOD INTAKE; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LEAN BODY WEIGHT; MALE; MEAL; NUTRITIONAL STATUS; OBESITY; POSTPRANDIAL STATE; YOUNG ADULT;

EID: 84892648444     PISSN: 18955770     EISSN: 18974317     Source Type: Journal    
DOI: 10.5114/pg.2013.39922     Document Type: Article

References (29)

1. Cummings DE, Purnell JQ, Frayo RS, et al. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001; 50: 1714-9.
2. Wannamethee SG, Tchernova J, Whincup P, et al. Plasma leptin: associations with metabolic, inflammatory and haemostatic risk factors for cardiovascular disease. Atherosclerosis 2007; 191: 418-26.
3. Soni AC, Conroy MB, Mackey RH, et al. Ghrelin, leptin, adiponectin, and insulin levels and concurrent and future weight change in overweight postmenopausal women. Menopause 2011; 18: 296-301.
4. Erdmann J, Lippl F, Wagenpfeil S, et al. Differential association of basal and postprandial plasma ghrelin with leptin, insulin and type 2 diabetes. Diabetes 2005; 54: 1371-8.
5. Tschop M, Weyer C, Tataranni PA, et al. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001; 50: 707-9.
6. Romon M, Gomila S, Hincker P, et al. Influence of weight loss on plasma ghrelin responses to high-fat and high-carbohydrate test meals in obese women. J Clin Endocrinol Metab 2006; 91: 1034-41.
7. Foster-Schubert KE, Overduin J, Prudom CE, et al. Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates. J Clin Endocrinol Metab 2008; 93: 1971-9.
8. Erdmann J, Topsch R, Lippl F, et al. Postprandial response of plasma ghrelin levels to various test meals in relation to food intake, plasma insulin and glucose. J Clin Endocrinol Metab 2004; 89: 3048-54.
9. Otto B, Cuntz U, Fruehauf E, et al. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 2001; 145: 669-73.
10. Miller KK. Endocrine dysregulation in anorexia nervosa update. J Clin Endocrinol Metab 2011; 96: 2939-49.
11. Murdolo G, Lucidi P, Di Loreto C, et al. Insulin is required for prandial ghrelin suppression in humans. Diabetes 2003; 52: 2923-7.
12. Karczewska-Kupczewska M, Straczkowski M, Adamska A, et al. Increased suppression of serum ghrelin concentration by hyperinsulinemia in women with anorexia nervosa. Eur J Endocrinol 2010; 162: 235-9.
13. Nedvidková J, Krykorková I, Barták V, et al. Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosa. J Clin Endocrinol Metab 2003; 88: 1678-82.
14. Rosická M, Krsek M, Matoulek M, et al. Serum ghrelin levels in obese patients: the relationship to serum leptin levels and soluble leptin receptors levels. Phys Rev 2003; 52: 61-6.
15. Caro JF, Kolaczynski JW, Nyce MR, et al. Decreased cerebrospinal-fluid/ serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996; 348: 159-61.
16. Pijl H. Leptin resistance. Ned Tijdschr Klin Chem Labgeneesk 2007; 32: 3-8.
17. Dallongeville J, Hecquet B, Lebel P, et al. Short term response of circulating leptin to feeding and fasting in man: influence of circadian cycle. Int J Obesity 1998; 22: 728-33.
18. Dostálová I, Kopský V, Dušková J, et al. Leptin concentrations in the abdominal subcutaneous adipose tissue of patients with anorexia nervosa assessed by in vivo microdialysis. Regul Pept 2005; 128: 63-8.
19. Ziora K, Oświȩcimska J, Świȩtochowska E, et al. Serum leptin levels in girls with anorexia nervosa [PoLish]. Endokrynol Pediatr 2010; 9: 43-53.
20. Haas V, Onur S, Paul T, et al. Leptin and body weight regulation in patients with anorexia nervosa before and during weight recovery. Am J Clin Nutr 2005; 81: 889-96.
21. Beasley JM, Ange BA, Anderson CA, et al. Characteristics associated with fasting appetite hormones (obestatin, ghrelin, and leptin). Obesity 2009; 17: 349-54.
22. Grinspoon S, Gulick T, Askari H, et al. Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab 1996; 81: 3861-3.
23. Prager R, Wallace P, Olefsky JM. Hyperinsulinemia does not compensate for peripheral insulin resistance in obesity. Diabetes 1987; 36: 327-34.
24. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000; 407: 908-13.
25. Flanagan DE, Evans ML, Monsod TP, et al. The influence of insulin on circulating ghrelin. Am J Physiol Endocrinl Metab 2003; 284: E313-6.
26. Tong J, Prigeon RL, Davis HW, et al. Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes 2010; 59: 2145-51.
27. Poykko SM, Kellokoski E, Horkko S, et al. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 2003; 52: 2546-53.
28. Friedman JM. Modern science versus the stigma of obesity. Nat Med 2004; 10: 563-9.
29. Misra M, Miller KK, Almazan C, et al. Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity. J Clin Endocrinol Metab 2004; 89: 3486-95.