Tear proteomic analysis of patients with type 2 diabetes and dry eye syndrome by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 1, 2014, Pages 177-186

  Li, Bing ^a   Sheng, Minjie ^a   Xie, Liqi ^b   Liu, Feng ^c   Yan, Guoquan ^b   Wang, Weifang ^a   Lin, Anjuan ^a   Zhao, Fei ^a   Chen, Yihui ^a  

^a TONGJI UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

Author keywords

Diabetes mellitus; Dry eye; Mass spectrometry; Proteomics; Tear

Indexed keywords

EID: 84892586556     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-12080     Document Type: Article

References (37)

1. Pflugfelder SC, Tseng SC, Sanabria O, et al. Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea. 1998;17:38-56.
2. Musch DC, Sugar A, Meyer RF. Demographic and predisposing factors in corneal ulceration. Arch Ophthalmol. 1983;101: 1545-1548.
3. de Paiva CS, Lindsey JL, Pflugfelder SC. Assessing the severity of keratitis sicca with videokeratoscopic indices. Ophthalmology. 2003;110:1102-1109.
4. Goto E, Yagi Y, Matsumoto Y, Tsubota K. Impaired functional visual acuity of dry eye patients. Am J Ophthalmol. 2002;133: 181-186.
5. Dogru M, Katakami C, Inoue M. Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus. Ophthalmology. 2001;108:586-592.
6. Seifart U, Strempel I. The dry eye and diabetes mellitus [in German]. Ophthalmologe. 1994;91:235-239.
7. Ramos-Remus C, Suarez-Almazor M, Russell AS. Low tear production in patients with diabetes mellitus is not due to Sjögren's syndrome. Clin Exp Rheumatol. 1994;12:375-380.
8. Goebbels M. Tear secretion and tear film function in insulin dependent diabetics. Br J Ophthalmol. 2000;84:19-21.
9. Manaviat MR, Rashidi M, Afkhami-Ardekani M, Shoja MR. Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. BMC Ophthalmol. 2008;8:10.
10. Jin J, Chen LH, Liu XL, Jin GS, Lou SX, Fang FN. Tear film function in non-insulin dependent diabetics [in Chinese]. Zhonghua Yan Ke Za Zhi. 2003;39:10-13.
11. Zhou L, Beuerman RW, Barathi A, Tan D. Analysis of rabbit tear proteins by high-pressure liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2003;17:401-412.
12. Fung KY, Morris C, Sathe S, Sack R, Duncan MW. Characterization of the in vivo forms of lacrimal-specific proline-rich proteins in human tear fluid. Proteomics. 2004;4:3953-3959.
13. Zhou L, Beuerman RW, Foo Y, Liu S, Ang LP, Tan DT. Characterisation of human tear proteins using high-resolution mass spectrometry. Ann Acad Med Singapore. 2006;35:400-407.
14. Koo BS, Lee DY, Ha HS, Kim JC, Kim CW. Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis. J Proteome Res. 2005;4: 719-724.
15. Fung K, Morris C, Duncan M. Mass spectrometric techniques applied to the analysis of human tears: a focus on the peptide and protein constituents. Adv Exp Med Biol. 2002;506:601-605.
16. Sakata M, Sack RA, Sathe S, Holden B, Beaton AR. Polymorphonuclear leukocyte cells and elastase in tears. Curr Eye Res. 1997;16:810-819.
17. van Haeringen NJ, Ensink FT, Glasius E. The peroxidasethiocyanate-hydrogenperoxide system in tear fluid and saliva of different species. Exp Eye Res. 1979;28:343-347.
18. Du J, Shi H, Lu Y, et al. Tagging single nucleotide polymorphisms in the PPAR-c and RXR-a gene and type 2 diabetes risk: a case-control study of a Chinese Han population. J Biomed Res. 2011;25:33-41.
19. Li Y, Jiang Y, Wan Y, et al. Medroxyprogestogen enhances apoptosis of SKOV-3 cells via inhibition of the PI3K/Akt signaling pathway. J Biomed Res. 2013;27:43-50.
20. Liu H, Finch JW, Luongo JA, Li GZ, Gebler JC. Development of an online two-dimensional nano-scale liquid chromatography/ mass spectrometry method for improved chromatographic performance and hydrophobic peptide recovery. J Chromatogr A. 2006;1135:43-51.
21. Keller A, Nesvizhskii AI, Kolker E, Aebersold R. Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal Chem. 2002;74:5383-5392.
22. Nesvizhskii AI, Keller A, Kolker E, Aebersold R. A statistical model for identifying proteins by tandem mass spectrometry. Anal Chem. 2003;75:4646-4658.
23. Dong MQ, Venable JD, Au N, et al. Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science. 2007;317:660-663.
24. Aluru SV, Agarwal S, Srinivasan B, et al. Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome. PLoS One. 2012;7:e51979.
25. Srinivasan S, Thangavelu M, Zhang L, Green KB, Nichols KK. iTRAQ quantitative proteomics in the analysis of tears in dry eye patients. Invest Ophthalmol Vis Sci. 2012;53:5052-5059.
26. Green-Church KB, Nichols KK, Kleinholz NM, Zhang L, Nichols JJ. Investigation of the human tear film proteome using multiple proteomic approaches. Mol Vis. 2008;14:456-470.
27. Zhou L, Beuerman RW, Chan CM, et al. Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics. J Proteome Res. 2009;8:4889-4905.
28. Kim HJ, Kim PK, Yoo HS, Kim CW. Comparison of tear proteins between healthy and early diabetic retinopathy patients. Clin Biochem. 2012;45:60-67.
29. Andrews E, Feldhoff P, Feldhoff R, Lassiter H. Comparative effects of cytokines and cytokine combinations on complement component C3 secretion by HepG2 cells. Cytokine. 2003;23:164-169.
30. Luo X, Liu L, Tang N, et al. Inhibition of monocyte-derived dendritic cell differentiation and interleukin-12 production by complement iC3b via a mitogen-activated protein kinase signalling pathway. Exp Dermatol. 2005;14:303-310.
31. Devaney JM, Greene CM, Taggart CC, Carroll TP, O'Neill SJ, McElvaney NG. Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4. FEBS Lett. 2003;544:129-132.
32. Chen HC, Lin HC, Liu CY, et al. Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway. J Biomed Sci. 2004;11:49-58.
33. Zoukhri D. Effect of inflammation on lacrimal gland function. Exp Eye Res. 2006;82:885-898.
34. Valentine JS, Doucette PA, Zittin Potter S. Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis. Annu Rev Biochem. 2005;74:563-593.
35. Behndig A, Svensson B, Marklund SL, Karlsson K. Superoxide dismutase isoenzymes in the human eye. Invest Ophthalmol Vis Sci. 1998;39:471-475.
36. Dahlman I, Eriksson P, Kaaman M, et al. Alpha2-Heremans-Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action. Diabetologia. 2004;47:1974-1979.
37. Elbein SC, Chu W, Ren Q, Wang H, Hemphill C, Hasstedt SJ. Evaluation of apolipoprotein A-II as a positional candidate gene for familial type II diabetes, altered lipid concentrations, and insulin resistance. Diabetologia. 2002;45:1026-1033.