Effect of alpha linolenic acid supplementation on serum Prostate Specific Antigen (PSA): Results from the alpha omega trial

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Brouwer, Ingeborg A ^a   Geleijnse, Johanna M ^b   Klaasen, Veronique M ^a,b   Smit, Liesbeth A ^a   Giltay, Erik J ^c   De Goede, Janette ^b   Heijboer, Annemieke C ^d   Kromhout, Daan ^b   Katan, Martijn B ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; LINOLENIC ACID; MARGARINE; PROSTATE SPECIFIC ANTIGEN;

ARTICLE; BLOOD LEVEL; CARDIOVASCULAR DISEASE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FACTORIAL DESIGN; FAT INTAKE; HEART INFARCTION; HUMAN; LOGISTIC REGRESSION ANALYSIS; MALE; MEDICAL HISTORY; PATIENT SELECTION; PROSTATE CANCER; RECURRENT DISEASE; RISK ASSESSMENT; STUDENT T TEST;

AGED; AGED, 80 AND OVER; ALPHA-LINOLENIC ACID; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; HUMANS; LOGISTIC MODELS; MALE; MARGARINE; MIDDLE AGED; MYOCARDIAL INFARCTION; PROSTATE; PROSTATE-SPECIFIC ANTIGEN;

EID: 84892575677     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081519     Document Type: Article

References (24)

1. Burdge GC, Jones AE, Wootton SA (2002) Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men. Br J Nutr 88: 355-363.
2. Goyens PL, Spilker ME, Zock PL, Katan MB, Mensink RP (2006) Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. Am J Clin Nutr 84: 44-53.
3. Elmadfa I, Kornsteiner M (2009) Fats and fatty acid requirements for adults. Ann Nutr Metab 55: 56-75.
4. Pan A, Chen M, Chowdhury R, Wu JH, Sun Q, et al. (2012) alpha-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. Am J Clin Nutr 96: 1262-1273.
5. Simon JA, Chen YH, Bent S (2009) The relation of alpha-linolenic acid to the risk of prostate cancer: a systematic review and meta-analysis. Am J Clin Nutr 89: 1558S-1564S.
6. Brouwer IA, Katan MB, Zock PL (2004) Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 134: 919-922.
7. Brouwer IA (2008) Omega-3 PUFA: good or bad for prostate cancer? Prostaglandins Leukot Essent Fatty Acids 79: 97-99.
8. Carayol M, Grosclaude P, Delpierre C (2010) Prospective studies of dietary alpha-linolenic acid intake and prostate cancer risk: a meta-analysis. Cancer Causes Control 21: 347-355.
9. Pelser C, Mondul AM, Hollenbeck AR, Park Y (2013) Dietary fat, fatty acids, and risk of prostate cancer in the NIH-AARP diet and health study. Cancer Epidemiol Biomarkers Prev 22: 697-707.
10. Geleijnse JM, Giltay EJ, Schouten EG, de Goede J, Oude Griep LM, et al. (2010) Effect of low doses of n-3 fatty acids on cardiovascular diseases in 4,837 post-myocardial infarction patients: design and baseline characteristics of the Alpha Omega Trial. Am Heart J 159: 539-546 e532.
11. Kromhout D, Giltay EJ, Geleijnse JM (2013) Fatty Acids and Cardiovascular Events after Myocardial Infarction. N Engl J Med.
12. Balk SP, Ko YJ, Bubley GJ (2003) Biology of prostate-specific antigen. J Clin Oncol 21: 383-391.
13. Orsted DD, Nordestgaard BG, Jensen GB, Schnohr P, Bojesen SE (2012) Prostate-specific antigen and long-term prediction of prostate cancer incidence and mortality in the general population. Eur Urol 61: 865-874.
14. Berger AP, Deibl M, Strasak A, Bektic J, Pelzer AE, et al. (2007) Large-scale study of clinical impact of PSA velocity: long-term PSA kinetics as method of differentiating men with from those without prostate cancer. Urology 69: 134-138.
15. Vickers AJ, Lilja H (2009) Prostate cancer: estimating the benefits of PSA screening. Nat Rev Urol 6: 301-303.
16. Catalona WJ, Richie JP, Ahmann FR, Hudson MA, Scardino PT, et al. (1994) Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men. J Urol 151: 1283-1290.
17. Smith DS, Humphrey PA, Catalona WJ (1997) The early detection of prostate carcinoma with prostate specific antigen: the Washington University experience. Cancer 80: 1852-1856.
18. Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, et al. (2008) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev 17: 3577-3587.
19. van Rossum CFV-K, J; Buurma-Rethans, EJM; Ocke, MC (2011) Dutch National Food Consumption Survey 2007-2010: Diet of children and adults aged 7 to 69 years. Bilthoven: RIVM.
20. Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A (2004) Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Am J Clin Nutr 79: 935-945.
21. Pandalai PK, Pilat MJ, Yamazaki K, Naik H, Pienta KJ (1996) The effects of omega-3 and omega-6 fatty acids on in vitro prostate cancer growth. Anticancer Res 16: 815-820.
22. Hamazaki K, Higashihara E, Terachi T, Takada H, Matsuda T, et al. (2006) The effect of eicosapentaenoic acid on prostate-specific antigen. In Vivo 20: 397-401.
23. Safarinejad MR, Shafiei N, Safarinejad S (2012) Effects of EPA, gamma-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. Br J Nutr: 1-8.
24. Brasky TM, Darke AK, Song X, Tangen CM, Goodman PJ, et al. (2013) Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the SELECT Trial. J Natl Cancer Inst 105: 1132-1141.