Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles

Archives of Toxicology

Volumn 88, Issue 1, 2014, Pages 65-75

  Xu, Jiegou ^a,b   Futakuchi, Mitsuru ^b   Alexander, David B ^a   Fukamachi, Katsumi ^b   Numano, Takamasa ^b   Suzui, Masumi ^b   Shimizu, Hideo ^b   Omori, Toyonori ^b   Kanno, Jun ^c   Hirose, Akihiko ^c   Tsuda, Hiroyuki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Epithelial hyperplasia of terminal bronchioles; Interstitial pneumonitis; Lung carcinogenesis; Lung fibrosis; Lung toxicity; Nanosized zinc oxide particles

Indexed keywords

BIS(2 HYDROXYPROPYL)NITROSAMINE; DRINKING WATER; ZINC CHLORIDE; ZINC OXIDE;

ANIMAL TISSUE; ARTICLE; BRONCHIOLE; CONTROLLED STUDY; CYTOTOXICITY; EPITHELIUM HYPERPLASIA; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INTERSTITIAL PNEUMONIA; LUNG; LUNG ALVEOLUS CELL; LUNG CARCINOGENESIS; MACROPHAGE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC RAT; TRANSMISSION ELECTRON MICROSCOPY; WILD TYPE;

RATTUS;

ANIMALS; BRONCHIOLES; CARCINOGENICITY TESTS; CHLORIDES; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GENES, RAS; HUMANS; HYPERPLASIA; LUNG DISEASES, INTERSTITIAL; LUNG NEOPLASMS; NANOPARTICLES; NITROSAMINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; ZINC COMPOUNDS; ZINC OXIDE;

EID: 84892573137     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1086-5     Document Type: Article

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