메뉴 건너뛰기




Volumn 13, Issue 1, 2014, Pages 62-71

CDK6 binds and promotes the degradation of the EYA2 protein

Author keywords

Cancer; Cdk6; Cell cycle; Degradation; EYA2; Progenitor cell; Proliferation

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIN DEPENDENT KINASE 6; CYCLOHEXIMIDE; DROSOPHILA PROTEIN; EYA PROTEIN; EYA2 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84892571196     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.26755     Document Type: Article
Times cited : (14)

References (42)
  • 1
    • 59149089409 scopus 로고    scopus 로고
    • A requirement for Cyclin-dependent kinase 6 in thymocyte development and tumorigenesis
    • PMID:19155308
    • Hu MG, Deshpande A, Enos M, Mao D, Hinds EA, Hu GF, Chang R, Guo Z, Dose M, Mao C, et al. A requirement for Cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res 2009; 69: 810-8; PMID:19155308; http://dx.doi.org/10.1158/0008-5472.CAN-08-2473
    • (2009) Cancer Res , vol.69 , pp. 810-818
    • Hu, M.G.1    Deshpande, A.2    Enos, M.3    Mao, D.4    Hinds, E.A.5    Hu, G.F.6    Chang, R.7    Guo, Z.8    Dose, M.9    Mao, C.10
  • 2
    • 4444247138 scopus 로고    scopus 로고
    • Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    • DOI 10.1016/j.cell.2004.08.002, PII S0092867404007500
    • Malumbres M, Sotillo R, Santamaría D, Galán J, Cerezo A, Ortega S, Dubus P, Barbacid M. Mammalian cells cycle without the D-type Cyclindependent kinases Cdk4 and Cdk6. Cell 2004; 118: 493-504; PMID:15315761; http://dx.doi.org/10.1016/j.cell.2004.08.002 (Pubitemid 39485668)
    • (2004) Cell , vol.118 , Issue.4 , pp. 493-504
    • Malumbres, M.1    Sotillo, R.2    Santamaria, D.3    Galan, J.4    Cerezo, A.5    Ortega, S.6    Dubus, P.7    Barbacid, M.8
  • 4
    • 0034667668 scopus 로고    scopus 로고
    • Manipulating the onset of cell cycle withdrawal in differentiated erythroid cells with Cyclin-dependent kinases and inhibitors
    • PMID:11023509
    • Matushansky I, Radparvar F, Skoultchi AI. Manipulating the onset of cell cycle withdrawal in differentiated erythroid cells with Cyclin-dependent kinases and inhibitors. Blood 2000; 96: 2755-64; PMID:11023509
    • (2000) Blood , vol.96 , pp. 2755-2764
    • Matushansky, I.1    Radparvar, F.2    Skoultchi, A.I.3
  • 5
    • 0038503565 scopus 로고    scopus 로고
    • Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes
    • Ericson KK, Krull D, Slomiany P, Grossel MJ. Expression of Cyclin-dependent kinase 6, but not Cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes. Mol Cancer Res 2003; 1: 654-64; PMID:12861051 (Pubitemid 36870518)
    • (2003) Molecular Cancer Research , vol.1 , Issue.9 , pp. 654-664
    • Ericson, K.K.1    Krull, D.2    Slomiany, P.3    Grossel, M.J.4
  • 7
    • 3242711209 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6
    • DOI 10.1128/MCB.24.15.6560-6568.2004
    • Ogasawara T, Kawaguchi H, Jinno S, Hoshi K, Itaka K, Takato T, Nakamura K, Okayama H. Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated downregulation of Cdk6. Mol Cell Biol 2004; 24:6560-8; PMID:15254224; http://dx.doi.org/10.1128/MCB.24.15.6560-6568.2004 (Pubitemid 38944337)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.15 , pp. 6560-6568
    • Ogasawara, T.1    Kawaguchi, H.2    Jinno, S.3    Hoshi, K.4    Itaka, K.5    Takato, T.6    Nakamura, K.7    Okayama, H.8
  • 8
    • 34247571525 scopus 로고    scopus 로고
    • Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPα interaction
    • DOI 10.1038/sj.emboj.7601675, PII 7601675
    • Fujimoto T, Anderson K, Jacobsen SE, Nishikawa SI, Nerlov C. Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPα interaction. EMBO J 2007; 26:2361-70; PMID:17431401; http://dx.doi.org/10.1038/sj.emboj.7601675 (Pubitemid 46685857)
    • (2007) EMBO Journal , vol.26 , Issue.9 , pp. 2361-2370
    • Fujimoto, T.1    Anderson, K.2    Jacobsen, S.E.W.3    Nishikawa, S.-I.4    Nerlov, C.5
  • 10
    • 32244441908 scopus 로고    scopus 로고
    • From cell cycle to differentiation: An expanding role for Cdk6
    • Grossel MJ, Hinds PW. From cell cycle to differentiation: an expanding role for cdk6. Cell Cycle 2006; 5: 266-70; PMID:16410727; http://dx.doi.org/10. 4161/cc.5.3.2385 (Pubitemid 43213495)
    • (2006) Cell Cycle , vol.5 , Issue.3 , pp. 266-270
    • Grossel, M.J.1    Hinds, P.W.2
  • 12
    • 81255205373 scopus 로고    scopus 로고
    • A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells
    • PMID:22094256
    • Anders L, Ke N, Hydbring P, Choi YJ, Widlund HR, Chick JM, Zhai H, Vidal M, Gygi SP, Braun P, et al. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell 2011; 20:620-34; PMID:22094256; http://dx.doi.org/10.1016/j.ccr.2011.10.001
    • (2011) Cancer Cell , vol.20 , pp. 620-634
    • Anders, L.1    Ke, N.2    Hydbring, P.3    Choi, Y.J.4    Widlund, H.R.5    Chick, J.M.6    Zhai, H.7    Vidal, M.8    Gygi, S.P.9    Braun, P.10
  • 13
    • 27144506205 scopus 로고    scopus 로고
    • Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6
    • DOI 10.1038/sj.emboj.7600775, PII 7600775
    • Laman H, Funes JM, Ye H, Henderson S, Galinanes-Garcia L, Hara E, Knowles P, McDonald N, Boshoff C. Transforming activity of Fbxo7 is mediated specifically through regulation of Cyclin D/cdk6. EMBO J 2005; 24: 3104-16; PMID:16096642; http://dx.doi.org/10.1038/sj.emboj.7600775 (Pubitemid 41486346)
    • (2005) EMBO Journal , vol.24 , Issue.17 , pp. 3104-3116
    • Laman, H.1    Funes, J.M.2    Ye, H.3    Henderson, S.4    Galinanes-Garcia, L.5    Hara, E.6    Knowles, P.7    McDonald, N.8    Boshoff, C.9
  • 14
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, CDKs and cancer: A changing paradigm
    • PMID:19238148
    • Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009; 9: 153-66; PMID:19238148; http://dx.doi.org/10. 1038/nrc2602
    • (2009) Nat Rev Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 15
    • 84878285037 scopus 로고    scopus 로고
    • The Eyes Absent proteins in development and disease
    • PMID:22971774
    • Tadjuidje E, Hegde RS. The Eyes Absent proteins in development and disease. Cell Mol Life Sci 2013; 70: 1897-913; PMID:22971774
    • (2013) Cell Mol Life Sci , vol.70 , pp. 1897-1913
    • Tadjuidje, E.1    Hegde, R.S.2
  • 17
    • 84880901185 scopus 로고    scopus 로고
    • EYA1 phosphatase function is essential to drive breast cancer cell proliferation through Cyclin D1
    • PMID:23636126
    • Wu K, Li Z, Cai S, Tian L, Chen K, Wang J, Hu J, Sun Y, Li X, Ertel A, et al. EYA1 phosphatase function is essential to drive breast cancer cell proliferation through Cyclin D1. Cancer Res 2013; 73: 4488-99; PMID:23636126; http://dx.doi.org/10.1158/0008-5472.CAN-12-4078
    • (2013) Cancer Res , vol.73 , pp. 4488-4499
    • Wu, K.1    Li, Z.2    Cai, S.3    Tian, L.4    Chen, K.5    Wang, J.6    Hu, J.7    Sun, Y.8    Li, X.9    Ertel, A.10
  • 18
    • 84874729909 scopus 로고    scopus 로고
    • The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition
    • PMID:23263983
    • Sun J, Karoulia Z, Wong EY, Ahmed M, Itoh K, Xu PX. The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. Mol Cell Biol 2013; 33: 927-36; PMID:23263983; http://dx.doi.org/10.1128/MCB.01516-12
    • (2013) Mol Cell Biol , vol.33 , pp. 927-936
    • Sun, J.1    Karoulia, Z.2    Wong, E.Y.3    Ahmed, M.4    Itoh, K.5    Xu, P.X.6
  • 19
    • 84856536436 scopus 로고    scopus 로고
    • Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties
    • PMID:21706047
    • Farabaugh SM, Micalizzi DS, Jedlicka P, Zhao R, Ford HL. Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties. Oncogene 2012; 31:552-62; PMID:21706047
    • (2012) Oncogene , vol.31 , pp. 552-562
    • Farabaugh, S.M.1    Micalizzi, D.S.2    Jedlicka, P.3    Zhao, R.4    Ford, H.L.5
  • 20
    • 77954057128 scopus 로고    scopus 로고
    • The Eyes Absent phosphatasetransactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells
    • PMID:20418914
    • Pandey RN, Rani R, Yeo EJ, Spencer M, Hu S, Lang RA, Hegde RS. The Eyes Absent phosphatasetransactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells. Oncogene 2010; 29: 3715-22; PMID:20418914; http://dx.doi.org/10.1038/onc.2010.122
    • (2010) Oncogene , vol.29 , pp. 3715-3722
    • Pandey, R.N.1    Rani, R.2    Yeo, E.J.3    Spencer, M.4    Hu, S.5    Lang, R.A.6    Hegde, R.S.7
  • 21
    • 84876190366 scopus 로고    scopus 로고
    • Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome
    • PMID:23435380
    • Patrick AN, Cabrera JH, Smith AL, Chen XS, Ford HL, Zhao R. Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome. Nat Struct Mol Biol 2013; 20: 447-53; PMID:23435380; http://dx.doi.org/10.1038/nsmb.2505
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 447-453
    • Patrick, A.N.1    Cabrera, J.H.2    Smith, A.L.3    Chen, X.S.4    Ford, H.L.5    Zhao, R.6
  • 23
    • 79959514392 scopus 로고    scopus 로고
    • MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome
    • PMID:21518926
    • Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, et al. MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome. Blood 2011; 117: 6895-905; PMID:21518926; http://dx.doi.org/10.1182/blood-2010-12-324699
    • (2011) Blood , vol.117 , pp. 6895-6905
    • Wang, Q.F.1    Wu, G.2    Mi, S.3    He, F.4    Wu, J.5    Dong, J.6    Luo, R.T.7    Mattison, R.8    Kaberlein, J.J.9    Prabhakar, S.10
  • 24
    • 0032764590 scopus 로고    scopus 로고
    • A yeast 2-hybrid system for discerning differential interactions using multiple baits
    • PMID:10585727
    • Grossel MJ, Wang H, Gadea B, Yeung W, Hinds PW. A yeast 2-hybrid system for discerning differential interactions using multiple baits. Nat Biotechnol 1999; 17: 1232-3; PMID:10585727; http://dx.doi.org/10.1038/70792
    • (1999) Nat Biotechnol , vol.17 , pp. 1232-1233
    • Grossel, M.J.1    Wang, H.2    Gadea, B.3    Yeung, W.4    Hinds, P.W.5
  • 25
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • van den Heuvel S, Harlow E. Distinct roles for Cyclin-dependent kinases in cell cycle control. Science 1993; 262: 2050-4; PMID:8266103; http://dx.doi.org/10.1126/science.8266103 (Pubitemid 24041887)
    • (1993) Science , vol.262 , Issue.5142 , pp. 2050-2054
    • Van Den Heuvel, S.1    Harlow, E.2
  • 26
    • 69749120549 scopus 로고    scopus 로고
    • Distinct subcellular distribution of Cyclin dependent kinase 6
    • PMID:19667758
    • Kohrt DM, Crary JI, Gocheva V, Hinds PW, Grossel MJ. Distinct subcellular distribution of Cyclin dependent kinase 6. Cell Cycle 2009; 8:2837-43; PMID:19667758; http://dx.doi.org/10.4161/cc.8.17.9521
    • (2009) Cell Cycle , vol.8 , pp. 2837-2843
    • Kohrt, D.M.1    Crary, J.I.2    Gocheva, V.3    Hinds, P.W.4    Grossel, M.J.5
  • 28
    • 0033569748 scopus 로고    scopus 로고
    • Cdk6 can shorten G (1) phase dependent upon the N-terminal INK4 interaction domain
    • PMID:10514479
    • Grossel MJ, Baker GL, Hinds PW. cdk6 can shorten G(1) phase dependent upon the N-terminal INK4 interaction domain. J Biol Chem 1999; 274:29960-7; PMID:10514479; http://dx.doi.org/10.1074/jbc.274.42.29960
    • (1999) J Biol Chem , vol.274 , pp. 29960-29967
    • Grossel, M.J.1    Baker, G.L.2    Hinds, P.W.3
  • 29
    • 0035891830 scopus 로고    scopus 로고
    • Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome
    • Buller C, Xu X, Marquis V, Schwanke R, Xu PX. Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome. Hum Mol Genet 2001; 10: 2775-81; PMID:11734542; http://dx.doi.org/10.1093/hmg/10.24.2775 (Pubitemid 34026459)
    • (2001) Human Molecular Genetics , vol.10 , Issue.24 , pp. 2775-2781
    • Buller, C.1    Xu, X.2    Marquis, V.3    Schwanke, R.4    Xu, P.-X.5
  • 30
  • 31
    • 68949120906 scopus 로고    scopus 로고
    • Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations
    • PMID:19497856
    • Patrick AN, Schiemann BJ, Yang K, Zhao R, Ford HL. Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations. J Biol Chem 2009; 284: 20781-90; PMID:19497856; http://dx.doi.org/10.1074/jbc. M109.016832
    • (2009) J Biol Chem , vol.284 , pp. 20781-20790
    • Patrick, A.N.1    Schiemann, B.J.2    Yang, K.3    Zhao, R.4    Ford, H.L.5
  • 32
    • 28844468834 scopus 로고    scopus 로고
    • Experimental tests to definitively determine ubiquitylation of a substrate
    • DOI 10.1016/S0076-6879(05)99017-4, PII S0076687905990174, 17, Ubiquitin and Protein Degradation, Part B
    • Bloom J, Pagano M. Experimental tests to definitively determine ubiquitylation of a substrate. Methods Enzymol 2005; 399: 249-66; PMID:16338361; http://dx.doi.org/10.1016/S0076-6879(05)99017-4 (Pubitemid 41772734)
    • (2005) Methods in Enzymology , vol.399 , pp. 249-266
    • Bloom, J.1    Pagano, M.2
  • 33
    • 59649130295 scopus 로고    scopus 로고
    • Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm
    • PMID:19217428
    • Xiong W, Dabbouseh NM, Rebay I. Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm. Dev Cell 2009; 16: 271-9; PMID:19217428; http://dx.doi.org/10.1016/j. devcel.2008.12.005
    • (2009) Dev Cell , vol.16 , pp. 271-279
    • Xiong, W.1    Dabbouseh, N.M.2    Rebay, I.3
  • 35
    • 79959917607 scopus 로고    scopus 로고
    • FoxM1: A master regulator of tumor metastasis
    • PMID:21712406
    • Raychaudhuri P, Park HJ. FoxM1: a master regulator of tumor metastasis. Cancer Res 2011; 71: 4329-33; PMID:21712406; http://dx.doi.org/10.1158/0008- 5472.CAN-11-0640
    • (2011) Cancer Res , vol.71 , pp. 4329-4333
    • Raychaudhuri, P.1    Park, H.J.2
  • 36
    • 34248995953 scopus 로고    scopus 로고
    • Cdh1
    • DOI 10.1038/sj.onc.1210122, PII 1210122
    • Christensen KL, Brennan JD, Aldridge CS, Ford HL. Cell cycle regulation of the human Six1 homeoprotein is mediated by APC(Cdh1). Oncogene 2007; 26: 3406-14; PMID:17130831; http://dx.doi.org/10.1038/sj.onc.1210122 (Pubitemid 46788881)
    • (2007) Oncogene , vol.26 , Issue.23 , pp. 3406-3414
    • Christensen, K.L.1    Brennan, J.D.G.2    Aldridge, C.S.3    Ford, H.L.4
  • 38
    • 0043162336 scopus 로고
    • An internal-coordiante monte carlo method for searching conformational space
    • Chang G, Guida C, Still WC. An internal-coordiante monte carlo method for searching conformational space. J Am Chem Soc 1989; 111: 4379-86; http://dx.doi.org/10.1021/ja00194a035
    • (1989) J Am Chem Soc , vol.111 , pp. 4379-4386
    • Chang, G.1    Guida, C.2    Still, W.C.3
  • 39
    • 0002709663 scopus 로고    scopus 로고
    • Hessian-Free Low-Mode Conformational Search for Large-Scale Protein Loop Optimization: Application to c-jun N-Terminal Kinase JNK3
    • DOI 10.1002/1096-987X(20010115)22:1<21 ::AID-JCC3>3.0.CO;2-I
    • Klossvary I, Keseru GM. Hessian-free low-mode conformational search for large-scale protein loop optimization: Application to c-jun N-terminal kinase JNK3. J Comput Chem 2001; 22: 21-30; http://dx.doi.org/10.1002/1096- 987X(20010115)22:1<21::AIDJCC3> 3.0.CO;2-I (Pubitemid 33645647)
    • (2001) Journal of Computational Chemistry , vol.22 , Issue.1 , pp. 21-30
    • Kolossvary, I.1    Keseru, G.M.2
  • 40
    • 0007793280 scopus 로고
    • Conformations of cycloheptadecane. A comparison of methods for confomational searching
    • Saunders M, Houk K, Wu Y-D. Conformations of cycloheptadecane. A comparison of methods for confomational searching. J Am Chem Soc 1990; 112:1419; http://dx.doi.org/10.1021/ja00160a020
    • (1990) J Am Chem Soc , vol.112 , pp. 1419
    • Saunders, M.1    Houk, K.2    Wu, Y.-D.3
  • 41
    • 6944227703 scopus 로고    scopus 로고
    • Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Gαi family
    • DOI 10.1124/mol.104.004093
    • Embry AC, Glick JL, Linder ME, Casey PJ. Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family. Mol Pharmacol 2004; 66: 1325-31; PMID:15308761; http://dx.doi.org/10.1124/mol.104. 004093 (Pubitemid 39411073)
    • (2004) Molecular Pharmacology , vol.66 , Issue.5 , pp. 1325-1331
    • Embry, A.C.1    Glick, J.L.2    Linder, M.E.3    Casey, P.J.4
  • 42
    • 0034644469 scopus 로고    scopus 로고
    • The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins
    • PMID:10906137
    • Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR. The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. J Biol Chem 2000; 275: 32129-34; PMID:10906137; http://dx.doi.org/10. 1074/jbc.M004577200
    • (2000) J Biol Chem , vol.275 , pp. 32129-32134
    • Fan, X.1    Brass, L.F.2    Poncz, M.3    Spitz, F.4    Maire, P.5    Manning, D.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.