Effect of a Randomised Controlled Vitamin D Trial on Insulin Resistance and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus

Hormone and Metabolic Research

Volumn 46, Issue 1, 2014, Pages 54-58

  Strobel, F ^a   Reusch, J ^a   Penna Martinez, M ^a   Ramos Lopez, E ^a   Klahold, E ^a   Klepzig, C ^b   Wehrle, J ^a   Kahles, H ^a   Badenhoop, K ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b Diabetes Outpatient Clinic Offenbach   (Germany)

Author keywords

C peptide; diabetes; HbA1c; insulin; metabolism; vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; C PEPTIDE; COLECALCIFEROL; GLUCOSE; HEMOGLOBIN A1C; INSULIN; PARATHYROID HORMONE; PLACEBO;

ADULT; AGED; ARTICLE; BODY MASS; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORRELATIONAL STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HOMA INDEX; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VERY ELDERLY; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ADULT; AGED; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; PLACEBOS; TREATMENT OUTCOME; VITAMIN D;

EID: 84892497653     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0033-1358453     Document Type: Article

References (43)

1. Guariguata L., Whiting D., Weil C., Unwin N. The International Diabetes Federation diabetes atlas methodology for estimating global and national prevalence of diabetes in adults. Diabetes Res Clin Pract: 2011; 94 322 332
2. Guariguata L. By the numbers: new estimates from the IDF Diabetes Atlas Update for 2012. Diabetes Res Clin Pract: 2012; 98 524 525
3. Andersson E. A., Allin K. H., Sandholt C. H., Borglykke A., Lau C. J., Ribel-Madsen R., Sparso T., Justesen J. M., Harder M. N., Jorgensen M. E., Jorgensen T., Hansen T., Pedersen O. Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic beta-cell function over five years of follow-up. Diabetes: 2013; 62 3610 3617
4. Pittas A. G., Nelson J., Mitri J., Hillmann W., Garganta C., Nathan D. M., Hu F. B., Dawson Hughes B. Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Program. Diabetes Care: 2012; 35 565 573
5. Van Belle T. L., Gysemans C., Mathieu C. Vitamin D and diabetes: the odd couple. Trends Endocrinol Metab: 2013; [Epub ahead of print]
6. Pittas A. G., Lau J., Hu F. B., Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab: 2007; 92 2017 2029
7. Hintzpeter B., Mensink G. B., Thierfelder W., Muller M. J., Scheidt-Nave C. Vitamin D status and health correlates among German adults. Eur J Clin Nutr: 2008; 62 1079 1089
8. Isaia G., Giorgino R., Adami S. High prevalence of hypovitaminosis D in female type 2 diabetic population. Diabetes Care: 2001; 24 1496
9. Mattila C., Knekt P., Mannisto S., Rissanen H., Laaksonen M. A., Montonen J., Reunanen A. Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care: 2007; 30 2569 2570
10. Pittas A. G., Dawson-Hughes B., Li T., Van Dam R. M., Willett W. C., Manson J. E., Hu F. B. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care: 2006; 29 650 656
11. Ford E. S., Ajani U. A., McGuire L. C., Liu S. Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care: 2005; 28 1228 1230
12. Hypponen E., Boucher B. J., Berry D. J., Power C. 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes: 2008; 57 298 305
13. Parikh S. J., Edelman M., Uwaifo G. I., Freedman R. J., Semega-Janneh M., Reynolds J., Yanovski J. A. The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab: 2004; 89 1196 1199
14. Lagunova Z., Porojnicu A. C., Lindberg F., Hexeberg S., Moan J. The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res: 2009; 29 3713 3720
15. McGill A. T., Stewart J. M., Lithander F. E., Strik C. M., Poppitt S. D. Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity. Nutr J: 2008; 7 4
16. Rueda S., Fernandez-Fernandez C., Romero F., Martinez de O. J., Vidal J. Vitamin D, PTH, and the metabolic syndrome in severely obese subjects. Obes Surg: 2008; 18 151 154
17. Alvarez J. A., Ashraf A. P., Hunter G. R., Gower B. A. Serum 25-hydroxyvitamin D and parathyroid hormone are independent determinants of whole-body insulin sensitivity in women and may contribute to lower insulin sensitivity in African Americans. Am J Clin Nutr: 2010; 92 1344 1349
18. Cheng S., Massaro J. M., Fox C. S., Larson M. G., Keyes M. J., McCabe E. L., Robins S. J., O'Donnell C. J., Hoffmann U., Jacques P. F., Booth S. L., Vasan R. S., Wolf M., Wang T. J. Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. Diabetes: 2010; 59 242 248
19. Chiu K. C., Chu A., Go V. L., Saad M. F. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr: 2004; 79 820 825
20. Forouhi N. G., Luan J., Cooper A., Boucher B. J., Wareham N. J. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes: 2008; 57 2619 2625
21. Kayaniyil S., Vieth R., Retnakaran R., Knight J. A., Qi Y., Gerstein H. C., Perkins B. A., Harris S. B., Zinman B., Hanley A. J. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care: 2010; 33 1379 1381
22. Liu E., Meigs J. B., Pittas A. G., McKeown N. M., Economos C. D., Booth S. L., Jacques P. F. Plasma 25-hydroxyvitamin d is associated with markers of the insulin resistant phenotype in nondiabetic adults. J Nutr: 2009; 139 329 334
23. Scragg R., Sowers M., Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care: 2004; 27 2813 2818
24. Zhao G., Ford E. S., Li C. Associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among U.S. adults without physician-diagnosed diabetes: NHANES 2003-2006. Diabetes Care: 2010; 33 344 347
25. Pittas A. G., Harris S. S., Stark P. C., Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care: 2007; 30 980 986
26. Sabherwal S., Bravis V., Devendra D. Effect of oral vitamin D and calcium replacement on glycaemic control in South Asian patients with type 2 diabetes. Int J Clin Pract: 2010; 64 1084 1089
27. von Hurst P. R., Stonehouse W., Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. Br J Nutr: 2010; 103 549 555
28. Hjelmesaeth J., Hofso D., Aasheim E. T., Jenssen T., Moan J., Hager H., Roislien J., Bollerslev J. Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study. Cardiovasc Diabetol: 2009; 8 7
29. Lippi G., Montagnana M., Targher G., Guidi G. C. Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults: response to Reis et al. Diabetes Care: 2007; 30 e135
30. Snijder M., van D. R., Visser M., Deeg D., Seidell J., Lips P. To: Mathieu C, Gysemans C, Giulietti A, Bouillon R (2005) Vitamin D and diabetes. Diabetologia 48: 1247-1257. Diabetologia: 2006; 49 217 218
31. Avenell A., Cook J. A., MacLennan G. S., McPherson G. C. Vitamin D supplementation and type 2 diabetes: a substudy of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438). Age Ageing: 2009; 38 606 609
32. de Boer I. H., Tinker L. F., Connelly S., Curb J. D., Howard B. V., Kestenbaum B., Larson J. C., Manson J. E., Margolis K. L., Siscovick D. S., Weiss N. S. Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative. Diabetes Care: 2008; 31 701 707
33. Luo C., Wong J., Brown M., Hooper M., Molyneaux L., Yue D. K. Hypovitaminosis D in Chinese type 2 diabetes: lack of impact on clinical metabolic status and biomarkers of cellular inflammation. Diab Vasc Dis Res: 2009; 6 194 199
34. Holick M. F. Vitamin D deficiency. N Engl J Med: 2007; 357 266 281
35. Dupont W. D., Plummer W. D. Jr. Power and sample size calculations. A review and computer program. Control Clin Trials: 1990; 11 116 128
36. Joergensen C., Gall M. A., Schmedes A., Tarnow L., Parving H. H., Rossing P. Vitamin D levels and mortality in type 2 diabetes. Diabetes Care: 2010; 33 2238 2243
37. Grimnes G., Emaus N., Joakimsen R. M., Figenschau Y., Jenssen T., Njolstad I., Schirmer H., Jorde R. Baseline serum 25-hydroxyvitamin D concentrations in the Tromso Study 1994-95 and risk of developing type 2 diabetes mellitus during 11 years of follow-up. Diabet Med: 2010; 27 1107 1115
38. Badenhoop K., Kahles H., Penna-Martinez M. Vitamin D, immune tolerance, and prevention of type 1 diabetes. Curr Diab Rep: 2012; 12 635 642
39. Cheng Q., Li Y. C., Boucher B. J., Leung P. S. A novel role for vitamin D: modulation of expression and function of the local renin-angiotensin system in mouse pancreatic islets. Diabetologia: 2011; 54 2077 2081
40. George P. S., Pearson E. R., Witham M. D. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med: 2012; 29 e142 e150
41. Rose K., Penna-Martinez M., Klahold E., Karger D., Shoghi F., Kahles H., Bayer M., Hintermann E., Pfeilschifter J. M., Badenhoop K., Ramos-Lopez E., Christen U. Influence of the vitamin D plasma level and vitamin D-related genetic polymorphisms on the immune status of patients with type 1 diabetes: a pilot study. Clin Exp Immunol: 2013; 171 171 185
42. Breslavsky A., Frand J., Matas Z., Boaz M., Barnea Z., Shargorodsky M. Effect of high doses of vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients. Clin Nutr: 2013; [Epub ahead of print]
43. Hossein-Nezhad A., Spira A., Holick M. F. Influence of vitamin d status and vitamin d3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. PLoS One: 2013; 8 e58725