Influence of the vitamin D plasma level and vitamin D-related genetic polymorphisms on the immune status of patients with type 1 diabetes: A pilot study

Clinical and Experimental Immunology

Volumn 171, Issue 2, 2013, Pages 171-185

  Rose, K ^a   Penna Martinez, M ^b   Klahold, E ^b   Karger D ^b   Shoghi, F ^b   Kahles, H ^b   Bayer, M ^a   Hintermann, E ^a   Pfeilschifter, J M ^a   Badenhoop, K ^b   Ramos Lopez, E ^b   Christen, U ^a  

^a ZAFES ^*  (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Autoimmunity; Dendritic cells; Metabolism; Polymorphism; Regulatory T cells

Indexed keywords

CALCITRIOL; INTERLEUKIN 4; VITAMIN D; VITAMIN D BINDING PROTEIN; VITAMIN D RECEPTOR;

ADULT; ARTICLE; BLOOD SAMPLING; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; FOLLOW UP; GENE EXPRESSION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; IMMUNE STATUS; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PILOT STUDY; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MIDDLE AGED; PILOT PROJECTS; POLYMORPHISM, GENETIC; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION FACTORS; VITAMIN D;

EID: 84872169455     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12013     Document Type: Article

References (47)

1. Todd JA. Etiology of type 1 diabetes. Immunity 2010; 32:457-467.
2. Christen U, von Herrath MG. Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference? Cell Mol Immunol 2011; 8:193-198.
3. Tracy S, Drescher KM, Jackson JD etal. Enteroviruses, type 1 diabetes and hygiene: a complex relationship. Rev Med Virol 2010; 20:106-116.
4. Hober D, Sauter P. Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host. Nat Rev Endocrinol 2010; 6:279-289.
5. Schubert C. News feature: the worm has turned. Nat Med 2004; 10:1271-1272.
6. Chatenoud L, You S, Okada H etal. 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: immune therapies of type 1 diabetes: new opportunities based on the hygiene hypothesis. Clin Exp Immunol 2010; 160:106-112.
7. Christen U, Benke D, Wolfe T etal. Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient. J Clin Invest 2004; 113:74-84.
8. Filippi CM, Estes EA, Oldham JE etal. Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. J Clin Invest 2009; 119:1515-1523.
9. Diana J, Brezar V, Beaudoin L etal. Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay. J Exp Med 2011; 208:729-745.
10. Wolden-Kirk H, Overbergh L, Christesen HT etal. Vitamin D and diabetes: its importance for beta cell and immune function. Mol Cell Endocrinol 2011; 347:106-120.
11. Hypponen E, Laara E, Reunanen A etal. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001; 358:1500-1503.
12. Mohr SB, Garland CF, Gorham ED etal. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia 2008; 51:1391-1398.
13. Sloka S, Grant M, Newhook LA. The geospatial relation between UV solar radiation and type 1 diabetes in Newfoundland. Acta Diabetol 2010; 47:73-78.
14. Janner M, Ballinari P, Mullis PE etal. High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes. Swiss Med Wkly 2010; 140:w13091.
15. Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev 1998; 78:1193-1231.
16. Ramos-Lopez E, Bruck P, Jansen T etal. CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev 2007; 23:631-636.
17. Bailey R, Cooper JD, Zeitels L etal. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes 2007; 56:2616-2621.
18. Cooper JD, Smyth DJ, Walker NM etal. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes 2011; 60:1624-1631.
19. Ramos-Lopez E, Bruck P, Jansen T etal. CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients. J Steroid Biochem Mol Biol 2007; 103:807-810.
20. Wang TJ, Zhang F, Richards JB etal. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 2010; 376:180-188.
21. Nejentsev S, Cooper JD, Godfrey L etal. Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes. Diabetes 2004; 53:2709-2712.
22. Kahles H, Morahan G, Todd JA etal. Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes. Genes Immun 2009; 10 (Suppl. 1):S60-S63.
23. Zhang J, Li W, Liu J etal. Polymorphisms in the vitamin D receptor gene and type 1 diabetes mellitus risk: an update by meta-analysis. Mol Cell Endocrinol 2012; 355:135-142.
24. Ongagna JC, Pinget M, Belcourt A. Vitamin d-binding protein gene polymorphism association with IA-2 autoantibodies in type 1 diabetes. Clin Biochem 2005; 38:415-419.
25. Jankosky C, Deussing E, Gibson RL etal. Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. Virus Res 2012; 163:424-430.
26. Baeke F, Takiishi T, Korf H etal. Vitamin D: modulator of the immune system. Curr Opin Pharmacol 2010; 10:482-496.
27. van Etten E, Dardenne O, Gysemans C etal. 1, 25-Dihydroxyvitamin D3 alters the profile of bone marrow-derived dendritic cells of NOD mice. Ann NY Acad Sci 2004; 1037:186-192.
28. van Halteren AG, Tysma OM, van Etten E etal. 1Alpha, 25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis. J Autoimmun 2004; 23:233-239.
29. Adorini L, Penna G, Giarratana N etal. Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases. J Cell Biochem 2003; 88:227-233.
30. Penna G, Amuchastegui S, Giarratana N etal. 1, 25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. J Immunol 2007; 178:145-153.
31. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16:1215.
32. Penna-Martinez M, Ramos-Lopez E, Stern J etal. Impaired vitamin D activation and association with CYP24A1 haplotypes in differentiated thyroid carcinoma. Thyroid 2012; 22:709-716.
33. Kurylowicz A, Ramos-Lopez E, Bednarczuk T etal. Vitamin d-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study. Exp Clin Endocrinol Diabetes 2006; 114:329-335.
34. Ramos-Lopez E, Kurylowicz A, Bednarczuk T etal. Vitamin D receptor polymorphisms are associated with Graves' disease in German and Polish but not in Serbian patients. Thyroid 2005; 15:1125-1130.
35. Badenhoop K, Walfish PG, Rau H etal. Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune disease. J Clin Endocrinol Metab 1995; 80:2112-2117.
36. Fu L, Yun F, Oczak M etal. Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation. Clin Biochem 2009; 42:1174-1177.
37. Sinotte M, Diorio C, Berube S etal. Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. Am J Clin Nutr 2009; 89:634-640.
38. Unger WW, Laban S, Kleijwegt FS etal. Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1. Eur J Immunol 2009; 39:3147-3159.
39. van Halteren AG, van Etten E, de Jong EC etal. Redirection of human autoreactive T-cells upon interaction with dendritic cells modulated by TX527, an analog of 1, 25 dihydroxyvitamin D(3). Diabetes 2002; 51:2119-2125.
40. Gregori S, Giarratana N, Smiroldo S etal. A 1alpha, 25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 2002; 51:1367-1374.
41. Gysemans CA, Cardozo AK, Callewaert H etal. 1, 25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice. Endocrinology 2005; 146:1956-1964.
42. Pakala SV, Kurrer MO, Katz JD. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J Exp Med 1997; 186:299-306.
43. Sawcer S, Hellenthal G, Pirinen M etal. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011; 476:214-219.
44. Khoo AL, Chai LY, Koenen HJ etal. Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals. Clin Exp Immunol 2011; 164:72-79.
45. Khoo AL, Koenen HJ, Chai LY etal. Seasonal variation in vitamin D levels is paralleled by changes in the peripheral blood human T cell compartment. PLoS ONE 2012; 7:e29250.
46. Kleijwegt FS, Laban S, Duinkerken G etal. Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells. J Immunol 2011; 187:6357-6364.
47. Christen U, Hintermann E, Holdener M etal. Viral triggers for autoimmunity: is the 'glass of molecular mimicry' half full or half empty? J Autoimmun 2010; 34:38-44.